C. Géraut

Académie Nationale de Médecine, Lutetia Parisorum, Île-de-France, France

Are you C. Géraut?

Claim your profile

Publications (26)24.79 Total impact

  • C. Géraut, L. Géraut, D. Tripodi
    [Show abstract] [Hide abstract]
    ABSTRACT: The occupational skin diseases affecting mechanics appear to represent approximately 10% of the cases of occupational dermatitis. Irritation or allergic skin diseases are observed. Irritants factors are multiple and the major allergens are the preservatives in oils and greases but also in soaps. Metals (chromium and cobalt) and rubber are often encountered allergens. In the metal machining workers irritation dermatitis are observed in relation with caustic effect due to the presence of amines and preservatives in too high concentration. Allergies are related to the presence of metals, biocides, emulsifiers and deodorants or fragrances. Prevention is essential in these jobs.
    Revue Française d'Allergologie 04/2012; 52(3):197–203. DOI:10.1016/j.reval.2012.01.012 · 0.35 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Nantes University Hospital comprises 20 activity sectors. To investigate the role of the work environment at the individual level, as well as the workplace level, in explaining the variability in employees' perception of stress. A self-administered enhanced Karasek Job Content Questionnaire was sent to employees. The main variables were the psychological job demand (PJD) score and the job decision latitude (JDL) score. Univariate and multivariate logistic regression analyses were conducted to estimate crude odds ratio (OR) and adjusted OR. One thousand eight hundred and sixty-eight workers were included. Nursing managers (25.9 ± 3.4), non-specialized nurses (25.6 ± 3.5) and physicians (25.3 ± 3.4) had the highest PJD. Cleaning staff (61.4 ± 11.4) and nurse aides (63.6 ± 8.8) had the lowest JDL. Items correlated with high PJD are: unacceptable work schedule, adjusted OR 2.16 (95% CI = 1.3-3.5); unsatisfactory workstation accessibility, OR 1.92 (95% CI = 1.1-3.2); getting from A to B, OR 1.67 (95% CI = 1.2-2.4); and heavy manual handling, OR 1.62 (95% CI = 1.1-2.3). Sleeping tablet use was linked to high PJD (P < 0.01), extra workload (P < 0.05) and tiredness (P < 0.05). Use of painkillers was correlated with musculoskeletal disorders (P < 0.05). Our study highlighted women >40 years old, nurse managers, physicians, permanent and/or full-time workers having a high PJD. Nursing aides, medical secretary and nurses presented with high strain. Better control measures should be implemented for those socioprofessional categories to improve prevention measures. This study should be repeated in the future with a multi-centre approach to determine the generalizability of the findings.
    Occupational Medicine 12/2011; 62(3):216-9. DOI:10.1093/occmed/kqr196 · 1.47 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Contact dermatitis to cutting fluids is a very frequent cause of occupational skin disease, with different mechanisms for those caused by irritation or allergies. The different allergens in question are many and complex. Different batteries of patch tests are available but the interpretation of the relevance of positive tests is not simple. The aim of this work is to make clearer the investigative methods and the interpretation of the relevance of the results of patch tests, for more effective prevention.
    European journal of dermatology: EJD 03/2011; 21(2):162-9. DOI:10.1684/ejd.2011.1343 · 1.95 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Wood dust is a well-established risk factor for intestinal type sinonasal adenocarcinoma. The 5-year overall survival has varied from 20% to 80% according T1-T4 stages; 5-year survival according to histologic subtype has varied from 20% to 50%. To date, no study has evaluated whether environmental, occupational, and personal risk factors have any impact on both overall and cancer-specific survival. We aimed to determine whether exposure to carcinogenic risk factors besides wood exposure can influence the survival of patients with sinonasal ethmoid carcinoma. Retrospective cohort study of the association of survival data and occupational and personal carcinogenic risk factors. All patients hospitalized for ethmoid adenocarcinoma at the Nantes University Hospital between 1988 and 2004 were included . Data concerning TNM classification, histology, type and quality of tumor resection at the macro- and microscopic level, and occupational and personal exposure to carcinogens were collected. Statistical analysis was conducted using univariate and multivariate linear regression. A total of 98 patients were included with a response rate of 98%. Data showed 86% of patients had been exposed to wood dust. The 5-year survival was 62%. We first identified four factors that independently influenced overall survival: diplopia (P = .0159), spread to the orbit (P = .0113), bilateral involvement (P = .0134), TNM stage (P < .001). When the analysis included all occupational environmental factors (wood dust, solvent, and metals exposure) as well as personal risk factors, the length of exposure to metals (P = .0307) and tobacco exposure (P = .0031) also were found to influence 5-year overall survival. We identified high prevalence of colon cancer (4%) and double cancer (18%). We showed exposure to both environmental (tobacco) and occupational (metal dust) factors could influence survival in the diagnosis of a cancer. Our study suggests that screening for colon cancer should be offered to wood dust workers. A prospective multicentric study should be necessary to confirm our results.
    The Laryngoscope 01/2011; 121(9):2011-8. DOI:10.1002/lary.21900 · 2.03 Impact Factor
  • C. Geraut, P. Frimat
    Archives des Maladies Professionnelles et de l Environnement 06/2010; 71(3):388-393. DOI:10.1016/j.admp.2010.03.049 · 0.09 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Inflammatory contact dermatitis is frequent in food industry workers (bakers, pastry cooks, butchers, porkbutchers and caterers, restaurants, slaughter-houses, etc.). It is due not only to foodstuff of plant origin (flour, fruits and vegetables) but also to foodstuff proteins of animal origin, as well as food additives, drinks and spices. The use of cleaning and sterilization products made more and more powerful to meet the demands of cleanliness and sterility in food stores is causing much occupational contact dermatitis, which simple preventive measures could avoid.
    Revue Française d Allergologie 04/2010; 50(3):109-123. DOI:10.1016/j.reval.2010.01.011 · 0.22 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-gamma Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients. Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST >/= 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered. All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST >/= 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation. The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST.
    Journal of Occupational Medicine and Toxicology 11/2009; 4:30. DOI:10.1186/1745-6673-4-30 · 1.23 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Sinonasal adenocarcinomas are uncommon tumors which develop in the ethmoid sinus after exposure to wood dust. Although the etiology of these tumors is well defined, very little is known about their molecular basis and no diagnostic tool exists for their early detection in high-risk workers. To identify genes involved in this disease, we performed gene expression profiling using cancer-dedicated microarrays, on nine matched samples of sinonasal adenocarcinomas and non-tumor sinusal tissue. Microarray results were validated by quantitative RT-PCR and immunohistochemistry on two additional sets of tumors. Among the genes with significant differential expression we selected LGALS4, ACS5, CLU, SRI and CCT5 for further exploration. The overexpression of LGALS4, ACS5, SRI, CCT5 and the downregulation of CLU were confirmed by quantitative RT-PCR. Immunohistochemistry was performed for LGALS4 (Galectin 4), ACS5 (Acyl-CoA synthetase) and CLU (Clusterin) proteins: LGALS4 was highly up-regulated, particularly in the most differentiated tumors, while CLU was lost in all tumors. The expression of ACS5, was more heterogeneous and no correlation was observed with the tumor type. Within our microarray study in sinonasal adenocarcinoma we identified two proteins, LGALS4 and CLU, that were significantly differentially expressed in tumors compared to normal tissue. A further evaluation on a new set of tissues, including precancerous stages and low grade tumors, is necessary to evaluate the possibility of using them as diagnostic markers.
    BMC Medical Genomics 11/2009; 2:65. DOI:10.1186/1755-8794-2-65 · 3.91 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Where allergic investigations are carried out for occupational dermatitis, appropriate tests must be performed but commercially available batteries are not always suitable for the working conditions and for the products handled by patients. During testing, the products being handled must thus be correctly diluted with full knowledge of their composition in order to prevent harmful effects, particularly caustic effects, and to avoid false positives and false negatives.
    Annales de Dermatologie et de Vénéréologie 08/2009; 136(8):600-601. DOI:10.1016/j.annder.2009.06.015 · 0.67 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Contact dermatitis to epoxydic and phenolic resins are the most frequent contact dermatoses due to plastics, in particular in the form of airborne dermatitis. The chemical formulas of the various components of these resins and their additives are complex and the patch tests available in the trade are insufficient and often arrive at a late stage in the progress of industry, in particular in advanced technologies like aeronautical engineering, shipbuilding or the new floor and wall coverings in buildings. This article is a review of the actions to be taken with these allergies, as well as with regards to their diagnosis, prevention and medico-legal compensation.
    European journal of dermatology: EJD 05/2009; 19(3):205-13. DOI:10.1684/ejd.2009.0666 · 1.95 Impact Factor
  • C Geraut, M Belli, L Geraut, D Tripodi
    [Show abstract] [Hide abstract]
    ABSTRACT: Where allergic investigations are carried out for occupational dermatitis, appropriate tests must be performed but commercially available batteries are not always suitable for the working conditions and for the products handled by patients. During testing, the products being handled must thus be correctly diluted with full knowledge of their composition in order to prevent harmful effects, particularly caustic effects, and to avoid false positives and false negatives.
    Annales de Dermatologie et de Vénéréologie 01/2009; 136(8-9):600-1. · 0.67 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Occupational skin diseases of chemical origin are frequent among hairdressers. They can be caused by hair dyes, in particular those containing para-amines (especially paraphenylenediamine); bleaching agents containing alkaline persulphates, which can cause eczema, contact urticaria, rhinitis and asthma; liquids used in permanents containing products derived from irritant, sensitizing glycolic acid; irritant and sensitizing shampoos, in particular those with coconut derivatives, proteins hydrolysates and ubiquitous perfumes. Other allergic factors which are observed episodically include nickel, glutaraldehyde, formaldehyde, ethyl cyanoacrylate and minoxidil (Regaine®). Prevention, which is essential, should start at the beginning of the training.
    Revue Française d Allergologie et d Immunologie Clinique 04/2008; 48(3-48):256-263. DOI:10.1016/j.allerg.2008.01.025 · 0.24 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objective The aim of this study was an evaluation of the occupational risk perceveid by the employees in a health care establishment in accordance with French legislation. Method An anonymous questionnaire based on JCQ, physical and environmental stressors was addressed to the employees. Employees were categorised by socioprofessional category (SPC), health care department or group, age, sex, professional statute. Results 1868 subjects were included in the study; major job strain was found in non specialized nurses, nurse aides and the health care executives. The main risk factors emerging are musculoskeletal symptoms in geriatric, orthopedics and traumatology departments, violence verbal and physical aggressiveness in psychiatric and emergency departments. Sleeping pills use seems related to a high psychological demand at work. It seems also related to a weaker social support. Analgesics consumption is related to perceived stress and musculoskeletal disorders.
    Archives des Maladies Professionnelles et de l Environnement 12/2007; 68(5):457-473. DOI:10.1016/S1775-8785(07)78217-6 · 0.09 Impact Factor
  • C. Géraut, D. Tripodi
    [Show abstract] [Hide abstract]
    ABSTRACT: Occupational skin diseases (irritation, ulceration, urticaria and immunological eczema) to aldehydes, especially formaldehyde, glutaraldehyde and glyoxal, have been recognized for a long time in France as occupational diseases entitled to compensation. The occupational circumstances where these conditions are encountered are primarily in health care workers, particularely those who sterilize endoscopy, dental and dialysis instruments, who conserve tissues (especially in anatomy and pathology laboratories), those who use cooling fluids during machining of metals, who handle plastics containing formol derivatives, as well as those who have contact with certain textiles, cosmetics or nails hardeners. These allergens are very frequently encountered (formol is included in the standard battery of contact allergens), but it is expected that their use will decrease because of the now-recognized cancerogenic character of formol and the inefficiency of glutaraldehyde in sterilization against prions. Preventive measures against these aldehydes are therefore essential.
    Revue Française d Allergologie et d Immunologie Clinique 04/2007; DOI:10.1016/j.allerg.2007.01.026 · 0.24 Impact Factor
  • C. Géraut, D. Tripodi
    01/2006; 1(3):1-10. DOI:10.1016/S1155-1925(06)71828-6
  • Source
    C Géraut, D Tripodi
    [Show abstract] [Hide abstract]
    ABSTRACT: R é s u m é. – Les dermatoses professionnelles représentent un peu moins de la moitié des maladies professionnelles et environ une affection cutanée sur dix qui motive une consultation dermatologique. Les causes de ces dermatoses sont infectieuses, ou liées à des agents physiques ou surtout chimiques. Les aspects cliniques de ces dermatoses sont fonction de la cause et du mécanisme mais on retrouve le plus souvent des dermatites d'irritation et des eczémas allergiques. Les professions les plus touchées sont dans l'ordre : les professions où on utilise des produits de nettoyage, le bâtiment et les travaux publics, la coiffure, les métiers où on assure des soins, les professions de la mise en oeuvre des matières plastiques, puis diverses professions comme la mécanique, la métallurgie, l'imprimerie et enfin toutes les professions amenant au contact de produits animaux ou végétaux.
    01/2006; 1(1). DOI:10.1016/S0246-0319(06)73827-4
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A well-organized and structured prevention program is an essential step in the care of individuals with occupational irritant or allergic dermatitis. It involves first the physician who is going to make the diagnosis; it then involves the occupational medicine physician who is the only one that can follow the worker in the workplace. For each profession, or even better, for each job within in a profession, validated, written, practical rules should be on hand. We have prepared a CD that provides answers to most of the questions that would be asked by a patient and by the physician responsible for prevention: movements to be avoided, availability of gloves and protective creams for tasks to be carried out, non-traumatizing methods of cleansing, the most appropriate measures to take after work, allergens to avoid, etc. A reminder of the regulations and the responsibility of the employer are essential.
    Revue Française d Allergologie et d Immunologie Clinique 04/2005; 45(3-45):237-247. DOI:10.1016/j.allerg.2005.02.005 · 0.24 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The aim of the study was to evaluate the presence of cerebral lesions in asymptomatic scuba divers and explain the causes of them: potential risk factors associating cardiovascular risk factors, low aerobic capacity, or characteristics of diving (maximum depth, ascent rate). Experienced scuba divers, over 40 years of age, without any decompression sickness (DCS) history were included. We studied 30 scuba divers (instructors) without any clinical symptoms. For all of them, we carried out a clinical examination with fatty body mass determination and we questioned them about their diving habits. A brain Magnetic Resonance imaging (MRI), an assessment of maximal oxygen uptake, glycemia, triglyceridemia, and cholesterolemia were systematically carried out. Cerebral spots of high intensity were found at 33 % in the scuba diving group and 30 % in the control group. In the diving group, abnormalities were related to unsafe scuba-diving or metabolic abnormalities. In our study, we did not find a significant relationship between the lesions of the central nervous system, and the age, depth of the dives, number of dives, and ergometric performances (maximal oxygen uptake, V.O (2max), serum level of blood lactate). Nevertheless, we found a significant relationship between the lesions of the central nervous system and ascent rate faster than 10 meters per minute (r = 0.57; p = 0.003) or presence of high level of cholesterolemia (r = 0.6; p = 0.001). We found concordant results using the Cochran's Test: meaningful link between the number of brain lesions and the speed of decompression (Uexp = 14 < Utable = 43; alpha = 0.05, p < 0.01). We concluded that hyperintensities can be explained by preformed nitrogen gas microbubbles and particularly in presence of cholesterol, when the ascent rate is up to 10 meters per minute. So, it was remarkable to note that asymptomatic patients practicing scuba diving either professionally or recreationally, presented lesions of the central nervous system. This survey permitted us to highlight in a population of professional divers, neurological and also cardiovascular abnormalities (ventricular arrhythmias); although none of them present any symptoms today. It seems therefore important to us to propose in the future, for a better prevention of neurological injuries, a systematic follow-up by maximal oxygen consumption measure, brain MRI, and cholesterolemia. In the same way, our results suggest a modification of the diving tables with a maximal decompression rate at 9 m . mn (-1).
    International Journal of Sports Medicine 11/2004; 25(8):575-81. DOI:10.1055/s-2004-821038 · 2.37 Impact Factor
  • D. Dupas, C. Géraut
    Archives des Maladies Professionnelles et de l Environnement 07/2004; 65(4):359-360. DOI:10.1016/S1775-8785(04)93462-5 · 0.09 Impact Factor
  • Contact Dermatitis 12/2003; 49(5):269-70. DOI:10.1111/j.0105-1873.2003.0225m.x · 3.62 Impact Factor

Publication Stats

105 Citations
24.79 Total Impact Points

Institutions

  • 2012
    • Académie Nationale de Médecine
      Lutetia Parisorum, Île-de-France, France
  • 2009–2011
    • University of Nantes
      Naoned, Pays de la Loire, France
  • 2002–2010
    • Centre Hospitalier Universitaire de Nantes
      Naoned, Pays de la Loire, France
  • 1999
    • CHU de Lyon - Groupement Hospitalier Edouard Herriot
      Lyons, Rhône-Alpes, France