-
[show abstract]
[hide abstract]
ABSTRACT: For an evaluation of the preoperative assessment of subungual glomus tumours, a non-invasive examination of the lesion is desirable. Previous studies, however, have not clearly demonstrated these findings. We examined two cases of subungual glomus tumours and applied the approximately 5-14 MHz broadband B-mode and C-mode ultrasound imaging methods combined with Color Doppler imaging (CDI) and B-flow imaging (BFI) to clarify the significance of the preoperative assessment. We confirmed the tumour's localization, size and depth, using B-mode and C-mode imaging; and tumour vascularity using CDI and BFI. BFI is a newly developed ultrasound technique that enhances the B-mode imaging quality of the blood flow, including high-frame-rate and high-spatial-resolution imagings. BFI revealed the exact fine blood vessels within the subungual small tumour with no blooming compared to CDI. Our results indicate that these ultrasound scanning imagings are non-invasive and nonionizing evaluation methods, and that an accurate preoperative diagnosis using these methods will result in more effective surgical excision and relief.
European journal of dermatology: EJD 17(1):67-9. · 2.53 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Buschke-Ollendorff syndrome is an autosomal dominant disease characterized by disseminated connective tissue nevi of elastic type and osteopoikilosis. We report a 6-year-old Japanese boy with connective tissue nevi that showed slightly grouped yellowish or skin-colored papules and nodules, distributed from birth over his right thigh, right buttock, and back. Radiologic skeletal survey revealed osteopoikilosis. A skin biopsy specimen obtained from a papule showed that collagen bundles in the dermis were thickened and homogenized. The elastic fibers were not increased but were coarse and clumped. The boy's father, at age 34, has had osteopoikilosis and similar papules and nodules on his left buttock and back for the preceding 18 years. We studied the paternal grandfather, aged 65. He had osteopoikilosis and similar skin lesions on his lumbar region. None of the three had a history of hearing loss or malignant tumor. To our knowledge, this is the first report of three generations of Buschke-Ollendorf syndrome in a Japanese family.
Pediatric Dermatology 22(2):133-7. · 1.07 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Pustular eruptions caused by anti-hypertension drugs are relatively rare. They have been reported with beta-adrenergic blocking agents, calcium channel blocker and angiotensin converting enzyme (ACE) inhibitors. Angiotensin II type 1 (AT 1) receptor antagonists, as a new class of drug for hypertension, has become an established and popular treatment. We describe a patient with generalized pustular psoriasis induced by candesartan cilexetil (AT1 receptor antagonist), who was previously diagnosed as flexural psoriasis. It is known that AT1 receptor antagonists do not increase the bradykinin level, inhibiting the renin-angiotensin system more potently than ACE inhibitor. But our results suggest that AT 1 receptor antagonists could have some ACE inhibitor potency as an up-regulator for bradykinin in our patient, with pustular eruptions developing on the psoriatic background. To the best of our knowledge, there have been no reported cases of pustular psoriasis associated with AT1 receptor antagonists.
European journal of dermatology: EJD 13(4):406-7. · 2.53 Impact Factor
