Nan Jia

Capital Medical University, Peping, Beijing, China

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Publications (3)0 Total impact

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    ABSTRACT: To compare the vascular risk factors between acute ischemic retinopathy (AIR) and nonarteritic anterior ischemic optic neuropathy (NAION). Single center retrospective study. Patients diagnosed of AIR and NAION from Jan 2008 to Jan 2009 in Beijing Tongren hospital were enrolled in this study. The demographical data, the results of blood tests, cardiac examinations, carotid vascular ultrasound and brain MRI were analyzed by Chi-square test. Ninety-one AIR patients and 143 NAION patients were enrolled. The mean age of the NAION patients (51.4 ± 8.9) was lower than that of the AIR group (55.4 ± 15.8) (t = 2.514, P = 0.013). There was no significant difference in the gender, smoking status, hypertension and fasting blood glucose levels between these two groups (χ(2) = 0.023, 2.727, 0.217, 0.012; all P > 0.05). The percentage of hypercholesterolemia (total cholesterol > 5.17 mmol/L) was 46.2% (66/143) in the NAION group and 26.4% (24/91) in the AIR group (χ(2) = 9.193, P = 0.002). Prevalence of carotid artery disease and ischemic heart disease was 13.2% (12/91) in the AIR group and 4.9% (7/143) in the NAION group (χ(2) = 5.125, P = 0.024). Carotid artery stenosis was present in 34.5% (30/87) patients in the AIR group, whereas none in the NAION group (χ(2) = 44.370, P = 0.000). Among 57 AIR patients and 127 NAION patients who finished brain MRI, the percentage of cerebral infarction was 47.4% (27/57) in the AIR group and 0.8% (1/127) in the NAION group (χ(2) = 66.210, P = 0.000). Cerebral white matter hyperintensities (WMH) were present in 66.9% (85/127) of the NAION group and 36.8% (21/57) in the AIR group (χ(2) = 66.46, P = 0.000). The mean age of NAION patients was lower than that of the AIR patients. Carotid artery stenosis and stroke, which might indicate large-middle vessel disease, are common in ischemic retinopathy. WMH with small vascular atherosclerosis, possibly caused by hypercholesterolemia, is more common in the NAION group.
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 12/2011; 47(12):1076-9. DOI:10.3760/cma.j.issn.0412-4081.2011.12.006
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    ABSTRACT: To investigate the ocular manifestation of benign intracranial hypertension (BIH). It was a retrospective case series study. Clinical data of BIH patients were investigated retrospectively, including symptom, fundus findings, visual acuity and visual field. It was a retrospective case series study. The majority of 67 patients were female (46 cases, 87%), of which 71.7% were over-weight. While ocular symptoms were reported in 94.0% (63 cases) of cases in whole disease course, 28 cases (41.8%) primarily presented with ocular symptoms, including transient bilateral loss of vision, visual deterioration and diplopia. Papilledema was found in 65 cases (97.0%), of which 54 cases (80.6%) were bilateral. Some patients showed unilateral papilledema (11 cases, 16.4%)and optic atrophy. Abnormal visual acuity was found in 95 eyes (70.9%), of which 35 eyes (26.4%) were below 20/200. Visual field abnormality was found in 89.8% of 49 tested cases. The most common visual field lesion was the enlargement of the blind spot (82 eyes, 83.7%), followed by general constriction in 24 eyes (24.5%), nasal step in 17 eyes (25.4%), central scotoma in 9 eyes (9.2%), Bjerrum scotoma in 22 eyes (22.4%) and arcuate scotoma in 14 eyes (14.3%). BIH is not really "benign", especially from the viewpoint of optic nerve function.
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 12/2010; 46(12):1071-4. DOI:10.3760/cma.j.issn.04124081.2010.12.005
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    ABSTRACT: To evaluate the demographic, risk factors and clinical characteristics of non-arteritic anterior ischemic optic neuropathy (NAION) and provide clinical guidance for this blindness disease. Retrospective study was used to investigate the data, which consists of 96 NAION consecutive patients in neurology department of our hospital from 2005 to 2008. The average age of NAION patients is 50.90 +/- 8.88 years (range, 34 - 78 years) and the median is 50 y. About 68.8% of patients are male. The prevalence of hypertension, diabetes mellitus and abnormal lipid level is 34.4% (33/96), 29.2% (21/96) and 59.4% (57/93) respectively. The predominant patterns of visual field loss are altitudinal and accurate defects. Visual acuity was improved (change of >/= 3 lines) in 44.4% of patients. The age of onset in NAION is relatively early in life, compared with cerebral vascular disease, and male seems to have a high incidence. The most common risk factor is metabolic syndrome. Subcortical and periventricular white matter lesions and myocardial ischemia might associate with NAION. Visual acuity showed improvement in some patients, but the long outcome is poor.
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 12/2009; 45(12):1064-7. DOI:10.3760/cma.j.issn.0412-4081.2009.12.003