Nora López

University of the Balearic Islands, Palma, Balearic Islands, Spain

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Publications (3)5.85 Total impact

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    ABSTRACT: Induction of brown-like adipocytes (brite) in white adipose tissues may allow the conversion of lipid storage cells in fat-burning cells. Little is known concerning browning potential in males compared with females. In this study, we aimed to analyse whether gender differences were present in gene expression of "brite" markers as well as the impact of dietary manipulation at both early stages and adulthood in rats. We have determined the expression of brite markers and genes associated with lipid and energy metabolism in inguinal adipose tissue in adult male and female rats. We have analysed the impact of high-fat (HF) diet in adult life and of early leucine supplementation (2 %) during lactation. Results show that although both genders have the potential to induce brite genes in inguinal adipose tissue, males expressed higher levels (CIDEA, HOXC9 and SHOX2), which would imply a higher browning capacity in comparison with females. Minor impact of HF diet in adult life was observed in most of the genes studied. Interestingly, results showed that early Leu was able to compromise the metabolic fate of white and brite adipocytes later in adult life. Leucine supplementation programmed higher expression of cell death-inducing DFFA-like effector, accompanied with induction of sterol regulatory element binding transcription 1c factor and lower UPC2 expression, particularly in females. In addition, Leucine supplementation was associated with higher expression of leptin and PPARγ and decreased carnitine palmitoyl transferase in both genders. Although the exact role of these adaptations needs further comprehensive analysis, dietary Leu supplementation at early age programmed inguinal adipose tissue in a gender specific manner.
    Genes & Nutrition 01/2014; 9(1):372. · 3.33 Impact Factor
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    ABSTRACT: Nutrigenomics is the study of the interaction of dietary factors with genes, examining the influence that certain nutrients have on their expression and therefore may either contribute to health (along with other environmental factors), for example through a healthy balanced diet, or determine the onset of certain diseases (e.g. obesity). Nutrients modulate molecular processes involving DNA structure, gene expression and metabolism, and these in surn may affect the organism’s development. In this context, breast milk, which constitutes our first food, has an essential role not only in promoting children's healthy growth, but also in preventing adult diseases, such as obesity. This review focuses on the potential modulation of genes by dietary food compounds, devoting particular attention to gene expression in the mammary gland. In addition the knowledge on milk composition from a nutrigenomics perspective and the likely health-outcomes will be analysed, in particular those associated with energy metabolism and body weight control that could be related to changes in milk composition. Finally, the role of milk leptin as a key factor in epigenetics and developmental plasticity is evaluated. Leptin would represent an essential nutrient during lactation in the protection against obesity and its metabolic-related disorders in later life.
    09/2013; , ISBN: 9781622572434
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    ABSTRACT: The aim of this study was to assess the effects of dietary leucine supplementation in lactating dams, particularly on energy homeostasis through signaling mechanisms in the central nervous system. Dams were fed ad libitum with standard diet during pregnancy (control dams) or supplemented with 2% leucine (leucine-supplemented dams) from delivery onwards. Food intake, body weight and composition were periodically recorded. Hypothalamus was collected at the end of lactation, and the expression of neuropeptide Y (NPY), agouti-related protein (AgRP) pro-opiomelanocortin (POMC), cocaine and amphetamine regulated transcript (CART), insulin receptor (InsR), ghrelin receptor (GSHR), melanocortin receptor (MCR4), leptin receptor (Ob-Rb) and suppressor of cytokine signaling 3 (SOCS3) were analyzed. Dietary leucine supplementation to lactating rats increased plasma leucine by 56%, modulated body composition and contributed to a tendency of higher ratio of lean/fat mass content of dams during lactation, without affecting food intake, thermogenesis capacity or body or tissue/organs weights. No differences in body weight of offspring from control and leucine-supplemented dams were found. The expression of orexigenic peptides (NPY and AgRP) decreased in leucine-dams, whereas the expression of anorexigenic peptides (POMC and CART), the hypothalamic receptors of insulin, ghrelin, melanocortin and leptin and SOCS3 did not change by leucine supplementation. In conclusion, increased leucine intake during lactation may contribute to a healthier profile of body composition in dams, without compromising the growth and development of the progeny by a mechanism associated with lower expression of orexigenic neuropeptides in hypothalamus.
    Peptides 03/2010; 31(7):1361-7. · 2.52 Impact Factor