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ABSTRACT: There is agreement that elderly people complain about word finding difficulties, particularly proper names. However, few studies have focused on the prevalence of this complaint in the general population, nor is it clearly known whether it is predictive of dementia. The aim of this study was to fill this gap using the PAQUID cohort. 1,838 people aged 65 or more completed questionnaires and neuropsychological evaluation regularly during 13 years. Results show that the complaint about proper name retrieval concerns 64% of people aged above 65 years, and the complaint about common names 30%. The complaint was not associated with enhanced risk of dementia, whereas short naming tests were. Only a marginal relation was found between these naming tests and word retrieval complaint. This study emphasizes the importance of proper name retrieval complaint in the general population and suggests that elderly subjects can be reassured in the absence of other symptoms.
Dementia and Geriatric Cognitive Disorders 04/2013; 35(5-6):313-321. · 2.14 Impact Factor
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F Delva,
C Pimouguet,
C Helmer,
K Péres,
B Bréchat, M Le Goff,
H Jacqmin-Gadda,
H Amieva,
J-M Orgogozo,
S Auriacombe,
C Berr,
C Tzourio,
P Barberger-Gateau,
J F Dartigues
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ABSTRACT: Background/Aims: This study was designed to develop a practical risk score for predicting 5-year survival after the diagnosis of dementia. Methods: Using the Paquid Study (prospective, population-based, long-term cohort study), we created a prognosis score with incident cases of dementia and validated it in another prospective, population-based, long-term cohort study, the Three City Study. - Results: Among the 3,777 subjects enrolled in the Paquid Study, 454 incident cases of dementia were included in this study. After a 5-year follow-up period, 319 (70.3%) were deceased. The score was constructed from three independent prognostic variables (gender, age at diagnosis and number of ADL restricted). The discriminant ability of the score was good with a c index of 0.754. Sensitivity was 64.7% and specificity 76.3%. In the validation cohort, the discriminant ability of the prognostic score with c statistics was 0.700. Sensitivity was 26.3% and specificity 95.4%. Conclusions: The prognostic factors selected in the predictive model are easily assessable, so this simple score could provide helpful information for the management of dementia, particularly to identify patients with duration of the disease greater than 5 years.
Neuroepidemiology 03/2013; 41(1):20-28. · 2.31 Impact Factor
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ABSTRACT: BackgroundWorldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment
and blindness, which contribute to disability in the elderly. Mainly three types of nutritional factors are investigated for
their potential protection against eye ageing: antioxidants; lutein and zeaxanthin (carotenoids which accumulate specifically
in the eye); omega 3 polyunsaturated fatty acids. Few epidemiological studies have been conducted in this field, particularly
in Europe.
ObjectiveThe Alienor (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) Study aims at assessing the associations of
eye diseases with nutritional factors, determined from plasma measurements and estimation of dietary intakes.
Design, setting and participantsSubjects were recruited in Bordeaux (France) from the ongoing population-based 3C study. In 2006–2008, 963 subjects from the
3C Study, aged 73 years or more, had an eye examination and will have follow-up eye examinations every 2 years.
MeasurementsVascular, genetic and nutritional factors were assessed at baseline (1999–2001) and follow-up examinations of the 3C Study.
Eye diseases were classified according to international classifications.
ResultsNutritional status and vascular disease and risk factors were similar between participants and non participants, except for
a slight difference in plasma triglycerides and HDL-cholesterol. As expected, the prevalence of eye diseases was high: early
and late ARM (28.4 % and 5.6 %, respectively), open-angle glaucoma and treated ocular hypertension (4.8 % and 10.0 %, respectively),
cataract extraction (45.2 %), retinopathy (8.4 %), retinal vein occlusion (1.1 %), epiretinal membrane (3.9 %), current use
of artificial tears (17.3 %).
ConclusionsThis study confirms the high prevalence of eye diseases in the elderly. Its main strength is the combination of nutritional,
vascular and genetic information, collected over a 7 year period of time before the first eye examination. It may help design
future interventional studies, which might be common with other age-related disorders, because of common nutritional factors.
Key wordsMacular degeneration–glaucoma–nutrition–antioxidants–fatty acids–epidemiology
The Journal of Nutrition Health and Aging 04/2012; 14(10):854-861. · 2.69 Impact Factor
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ABSTRACT: To examine associations between metabolic syndrome (MetS) and its individual components with risk of cognitive decline on specific cognitive functions.
Participants were 4,323 women and 2,764 men aged 65 and over enrolled in the longitudinal Three-City Study. Cognitive decline, defined as being in the worst quintile of the distribution of the difference between baseline score and either 2- or 4-year follow-up, was assessed by the Mini-Mental State Examination (MMSE, global cognitive function), the Isaacs Set Test (IST, verbal fluency), and the Benton Visual Retention Test (BVRT, visual working memory). MetS was defined by National Cholesterol Education Program-Adult Treatment Panel III criteria (at least 3 of 5 cardio-metabolic abnormalities: hypertension, high waist circumference, hypertriglyceridemia, low high-density lipoprotein [HDL] cholesterol, hyperglycemia). Proportional hazards models were adjusted for age, gender, educational level, center, baseline cognitive score, APOE4 genotype, and other potential confounders.
MetS at baseline was associated with an increased risk of cognitive decline on MMSE (hazard ratio [HR] = 1.22 [1.08-1.37]; p = 0.001) and BVRT (HR = 1.13 [1.01-1.26]; p = 0.03) but not on IST (HR = 1.11 [0.95-1.29]; p = 0.18). Among MetS components, hypertriglyceridemia and low HDL cholesterol were significantly associated with higher decline on MMSE; diabetes, but not elevated fasting glycemia, was significantly associated with higher decline on BVRT and IST.
MetS as a whole and several of its components had a negative impact on global cognitive decline and specific cognitive functions in older persons.
Neurology 02/2011; 76(6):518-25. · 8.31 Impact Factor
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[show abstract]
[hide abstract]
ABSTRACT: Worldwide, degenerative eye diseases (age-related maculopathy (ARM), cataract, glaucoma) are the main causes of visual impairment and blindness, which contribute to disability in the elderly. Mainly three types of nutritional factors are investigated for their potential protection against eye ageing: antioxidants; lutein and zeaxanthin (carotenoids which accumulate specifically in the eye); omega 3 polyunsaturated fatty acids. Few epidemiological studies have been conducted in this field, particularly in Europe.
The Alienor (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) Study aims at assessing the associations of eye diseases with nutritional factors, determined from plasma measurements and estimation of dietary intakes.
Subjects were recruited in Bordeaux (France) from the ongoing population-based 3C study. In 2006-2008, 963 subjects from the 3C Study, aged 73 years or more, had an eye examination and will have follow-up eye examinations every 2 years.
Vascular, genetic and nutritional factors were assessed at baseline (1999-2001) and follow-up examinations of the 3C Study. Eye diseases were classified according to international classifications.
Nutritional status and vascular disease and risk factors were similar between participants and non participants, except for a slight difference in plasma triglycerides and HDL-cholesterol. As expected, the prevalence of eye diseases was high: early and late ARM (28.4 % and 5.6 %, respectively), open-angle glaucoma and treated ocular hypertension (4.8 % and 10.0 %, respectively), cataract extraction (45.2 %), retinopathy (8.4 %), retinal vein occlusion (1.1 %), epiretinal membrane (3.9 %), current use of artificial tears (17.3 %).
This study confirms the high prevalence of eye diseases in the elderly. Its main strength is the combination of nutritional, vascular and genetic information, collected over a 7 year period of time before the first eye examination. It may help design future interventional studies, which might be common with other age-related disorders, because of common nutritional factors.
The Journal of Nutrition Health and Aging 10/2010; 14(10):854-61. · 2.69 Impact Factor
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ABSTRACT: Verbal fluency tasks are frequently used in neuropsychological examinations. The aim of this study was to produce norms for a normal elderly population in semantic (colors, animals, fruits, city names) and letter fluency (letters "L" and "P") tasks performed in 60 seconds.
These data were collected as part of the PAQUID cohort, a French population-based study on aging conducted in Gironde and Dordogne.
The sub-sample analyzed included 1730 non-institutionalized and non-demented subjects. Norms were calculated according to age (70-74 years, 75-79 years, >or=80 years), sex and educational level (no diploma, primary degree, secondary degree and higher). For each task, the number of correct words produced and repetition errors were analyzed.
The contribution of this work is to provide clinicians with normative scores for semantic and letter fluency tasks helpful for interpreting the performances of elderly patients consulting for cognitive disorders.
Revue Neurologique 03/2010; 166(6-7):594-605. · 0.49 Impact Factor
