Loyola D'Silva

Publications (1)4.19 Total impact

• Article: Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging.

  Gautom Kumar Das, Boon Chin Heng, Sui-Choon Ng, Tim White, Joachim Say Chye Loo, Loyola D'Silva, Parasuraman Padmanabhan, Kishore K Bhakoo, Subramanian Tamil Selvan, Timothy Thatt Yang Tan
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  ABSTRACT: We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd(2)O(3):RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd(2)O(3) NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.
  Langmuir 02/2010; 26(11):8959-65. · 4.19 Impact Factor