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ABSTRACT: Der Fall einer 18-jährigen Patientin mit einem ausgedehnten intraartikulären Tumor des rechten Hüftgelenks und einer sekundärer
Osteolyse am Schenkelhals wird dargestellt. Magnetresonanztomographie (MRT) und Biopsie ergaben die Diagnose einer fokalen
villonodulären Synovitis. Durch die Hüftarthroskopie konnte der Tumor komplett entfernt und die Osteolyse mit einem exzellenten
klinischen Ergebnis vollständig ausgeräumt werden. Die Hüftarthroskopie hat den Vorteil des geringeren Operationstraumas und
des sehr guten frühfunktionellen Ergebnisses. Auch ausgedehnte intraartikuläre Tumore können im Einzelfall vollständig durch
Hüftarthroskopie behandelt werden.
We present the clinical case of an 18-year-old woman who complained of acute hip pain. MRI showed an intra-articular tumor
4cm in size with osteolysis (18 mm) on the distal region of the femoral head-neck junction. Focal pigmented villonodular
synovitis infiltrating the bone was diagnosed. A complete resection of the tumor including the osteolytic area was done by
an arthroscopic procedure. There was no sign of relapse after 8 months of follow-up, with no pain and complete function of
the hip. Arthroscopic treatment has the advantage of minimal surgical trauma and good mid-term results for treating a focal
lesion in selected cases.
SchlüsselwörterHüftarthroskopie-Villonoduläre Synovitis-Tumor-Osteolyse-Hüftgelenk
KeywordsFocal pigmented-Villonodular synovitis-Hip arthroscopy-Tumor-Osteolysis hipjoint
Der Orthopäde 04/2012; 39(5):512-515. · 0.51 Impact Factor
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ABSTRACT: Intra-articular injuries are common after dislocation and fracture of the hip joint and can be addressed using hip arthroscopy. The most common indications for this procedure are loose bodies, labral tears and chondral defects. In addition, preexisting femoroacetabular impingement can be addressed at the time of surgery. Arthroscopically guided fracture reduction and fixation has been described. We present two case reports of intra-articular lesions after traumatic hip dislocation. The first is a case of a man with an anterior labral tear and loose bodies after closed hip reduction. The second case is a man with a large anterior labral tear with preexisting femoroacetabular impingement. Both of them were treated by arthroscopic debridement of the unstable labrum. In addition loose bodies were removed in the first patient and a femoral osteoplasty was performed in the second patient. Hip arthroscopy has proven to be a safe and effective surgical technique for treating specific post-traumatic lesions and preexisting femoroacetabular impingement. The current case reports provide an overview of the indication for hip arthroscopy following traumatic injuries to the hip.
Der Unfallchirurg 05/2011; 115(3):273-8. · 0.61 Impact Factor
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ABSTRACT: We present the clinical case of an 18-year-old woman who complained of acute hip pain. MRI showed an intra-articular tumor 4 cm in size with osteolysis (18 mm) on the distal region of the femoral head-neck junction. Focal pigmented villonodular synovitis infiltrating the bone was diagnosed. A complete resection of the tumor including the osteolytic area was done by an arthroscopic procedure. There was no sign of relapse after 8 months of follow-up, with no pain and complete function of the hip. Arthroscopic treatment has the advantage of minimal surgical trauma and good mid-term results for treating a focal lesion in selected cases.
Der Orthopäde 03/2010; 39(5):512-5. · 0.51 Impact Factor
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ABSTRACT: The pathophysiology of the testicular damage in varicocele has not been completely understood. Oxidative stress and related sperm DNA damage have been identified as significant causes of male infertility. The current study was designed to determine the extent of sperm nuclear DNA damage in patients with varicocele and to examine its relationship with oxidative stress.
Semen samples from 55 patients with clinical varicocele and 25 normozoospermic donors were examined. Varicocele sperm samples were classified as normal or abnormal according to World Health Organization guidelines. Sperm DNA damage was evaluated by the sperm chromatin structure assay/flow cytometry and by the terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) assay. Levels of reactive oxygen species (ROS) and total antioxidant capacity were assessed by a chemiluminescence assay.
DNA fragmentation index (DFI) (percentage of sperm with denatured DNA) values and the percentage of TUNEL-positive cells were significantly greater in patients with varicocele, either with normal (DFI, 20.7 +/- 4.0; TUNEL positive, 26.1 +/- 3.2) or with abnormal (DFI, 35.5 +/- 9.0; TUNEL positive, 32.2 +/- 4.1) semen profile, compared with controls (DFI, 7.1 +/- 0.9; TUNEL positive, 14.2 +/- 1.2). Similarly, ROS levels were significantly higher (P < 0.01) in both groups of patients with varicocele.
The presence of a varicocele is associated with high levels of DNA-damage spermatozoa even in the presence of normal semen profile. The results also indicate that oxidative damage is associated with sperm DNA damage in these patients.
Human Reproduction 05/2006; 21(4):986-93. · 4.47 Impact Factor
