Feng-Lou Wang

Publications (2)0 Total impact

• Article: [Localization of epileptic foci in frontal lobe epilepsy and its surgical therapy].

  Qing Yu, Wei-dong Yang, Zeng-guang Wang, Shuo Gao, Jing-yuan Xue, Zhi-juan Chen, Ying Chen, Feng-lou Wang
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  ABSTRACT: To analyze the clinical data and pre-operative examination results of frontal lobe epilepsy and combine with intra-operative intracranial electrical record in order to localize epileptic foci and to direct surgical therapy. Preoperative EEG record and MRI scan were performed in 23 patients with refractory frontal lobe epilepsy. Among them, 17 patients received interictal 18F-FDG-PET-CT, 11 received MEG examination, 2 received functional MRI, 10 received surgical operation and intra-operative intracranial electrical record. The positive predictive value of clinical features of epileptic seizure, interictal EEG, ictal EEG, MRI and PET-CT were 56.52%, 56.52%, 60.87%, 54.55% and 94.12% respectively. Their consistent results helped to confirm the epileptogenic zone. MEG was more accurate than EEG. ECoE and VEEG monitoring was significant for operative guidance. A series of examinations is necessary for the diagnosis of epileptogenic zone of frontal lobe epilepsy. The surgical outcome is related to the accuracy of epileptic foci localization and the removal of epileptogenic zone.
  Zhonghua yi xue za zhi 02/2010; 90(7):462-5.
• Article: [Stereotactic combined amygdala and hippocampus lesions for treatment of medial temporal lobe epilepsy].

  Wei-dong Yang, Qing Yu, Jian-ning Zhang, Chang-hong Shen, Feng-lou Wang, Lin-yang Cui, Hong Li, Shu-yuan Yang
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  ABSTRACT: To explore the techniques of stereotactic combined amygdalohippocampotomy for management of medial temporal lobe epilepsy (MTLE). The Leksell stereotactic frame was used for all cases, and which almost paralleled the long axis of hippocampus. Stereotactic amygdalohippocampotomy was performed in 23 patients with unilateral medial temporal lobe seizures by using magnetic resonance imaging (MRI) localization for target planning, depth electrode for the electroencephalogram (EEG) monitoring and radiofrequency techniques for lesion production. All procedures were completed under local anesthesia. Pre-lesion spikes or polyspike-waves complex were recorded by a depth electrode in the amygdala and hippocampus region in all patients, and the epileptiform discharges disappeared after the amygdalohippocampotomy. The MRI appearance of the lesion areas after 1 - 2 weeks surgical operation showed that mutiple areas of coagulation necrosis corresponding to the lesion sites were surrounded by zones of edema. Twenty-three patients were followed-up to 8 - 32 months with seizure free 43.48% (10/23), and the general efficiency (seizure reduction >or= 50%) was 91.30% (21/23 cases). Stereotactic combined lesions of unilateral amygdala and hippocampus for minimally invasive treatment of MTLE is safe and effective, and it is worth to spread in clinical application.
  Zhonghua wai ke za zhi [Chinese journal of surgery] 06/2005; 43(9):616-9.