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Publications (2)2.42 Total impact

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    ABSTRACT: A novel zoledronic acid (ZL) derivative, 1-hydroxy-2-(2-ethyl-4-methyl-1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid (EMIDP), was prepared and labeled with (99)(m)Tc successfully in a high labeling yield and good stability in vitro. The preclinical pharmacological properties of (99)(m)Tc-EMIDP were investigated and compared with (99)(m)Tc-MDP and (99)(m)Tc-ZL. The studies of biodistribution in mice and SPECT bone imaging of the rabbit suggest that (99)(m)Tc-EMIDP has highly selective uptake in the skeletal system and rapid clearance in the soft tissues. The present findings indicate that (99)(m)Tc-EMIDP holds great potential for bone scintigraphy.
    Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine 03/2010; 68(9):1616-22. · 1.09 Impact Factor
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    ABSTRACT: A facile procedure was described for the hapten design of the N-methylcarbamate insecticide propoxur. Two new haptens of propoxur (hapten 1a and hapten 1b) were synthesized by introducing appropriate spacers in the pesticide aromatic moiety of the analyte molecular structure. First, the propoxur reacted with nitric acid to yield the intermediate product. Then hapten 1a was prepared via the reduction of the intermediate product, and hapten 1b was formed by the acylation of hapten 1a with succinic anhydride. In addition, we have also developed a simple method to prepare hapten 2 for the pyrethroid insecticide cyhalothrin, which only requires two steps including the reactions of nitration and reduction. Three haptens were coupled to carrier proteins to prepare the corresponding artificial antigens. The molecular structures of these three haptens were identified by 1H NMR and MS, and those of the artificial antigens were confirmed by UV-vis. Keywordshapten design-insecticide-synthesis-artificial antigen
    Science China-Chemistry 01/2010; 53(5):1108-1113. · 1.33 Impact Factor