[show abstract][hide abstract] ABSTRACT: This 8-week, randomized, placebo-controlled, double-blind clinical study investigated the short-term effectiveness and safety of the traditional Chinese medicine, Ningdong (ND) granule in paediatric subjects (aged 7 - 18 years) with Tourette's disorder (TD). Subjects received either 1 g/kg per day ND granule (n = 33) or placebo (n = 31) and tics were measured at baseline and after 4 and 8 weeks of treatment. Body mass index, electrocardiogram and laboratory measures were recorded at baseline and at week 8. After 8 weeks of treatment with ND granule, subjects exhibited a 41.39% reduction in the total tic score while the placebo group showed a 10.79% decrease. Regarding side-effects, two subjects reported loss of appetite and one experienced constipation in the ND granule group. There were no significant changes in laboratory and physical examinations. These results suggest that ND granule is both effective and safe, and may be a good candidate for the treatment of patients with TD.
The Journal of international medical research 02/2010; 38(1):169-75. · 0.96 Impact Factor
[show abstract][hide abstract] ABSTRACT: Cinobufacini, a water-soluble preparation of Chinese medicine, is extracted from the skin of Bufo bufo gargarizans Cantor. The present study sought to investigate the effects of Cinobufacini on apoptosis of the hepatocellular carcinoma cell line BEL-7402. Cell viability was measured by methyl thiazolyl tetrazolium assay. Cell morphology was observed by Hoechst 33258 staining. Western blotting analysis was used to detect Bax and Bcl-2 expression. Results indicated that Cinobufacini inhibited the proliferation of BEL-7402 cells in a dose and time-dependent manner. Marked morphological changes indicative of apoptosis were observed after treatment with different concentrations of Cinobufacini. Western blot analysis showed that Bcl-2 expression was down-regulated while Bax expression was upregulated. Thus, Cinobufacini may have a significant apoptosis-inducing effect on BEL-7402 cells, and this could prove useful for further anti-cancer research.
Drug discoveries & therapeutics. 12/2008; 2(6):339-43.