J R Thistlethwaite

University of Chicago, Chicago, Illinois, United States

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Publications (214)1043.98 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Background In the US, African Americans and Whites differ in access to the deceased donor renal transplant waitlist. The extent to which racial disparities in waitlisting differ between United Network for Organ Sharing (UNOS) regions is understudied.Methods The US Renal Data System (USRDS) was linked with US Census data to examine time from dialysis initiation to wait-listing for Whites (n=188,410) and African Americans (n= 144,335) using Cox proportional hazards across 11 UNOS regions, adjusting for potentially confounding individual, neighborhood, and state characteristics.ResultsLikelihood of wait-listing varies significantly by UNOS region, overall and by race. Additionally, African Americans face significantly lower likelihood of waitlisting compared to Whites in all but two regions (1 and 6). Overall 39% of African Americans with ESRD reside in Regions 3 and 4—regions with a large racial disparity and where African Americans comprise a large proportion of the ESRD population. In these regions, the African American-White disparity is an important contributor to their overall regional disparity.Conclusions Race remains an important factor in time to transplant waitlist in the US. Race contributes to overall regional disparities; however, the importance of race varies by UNOS region.This article is protected by copyright. All rights reserved.
    Clinical Transplantation 03/2015; DOI:10.1111/ctr.12547 · 1.49 Impact Factor
  • Lainie Friedman Ross, J Richard Thistlethwaite
    JAMA The Journal of the American Medical Association 07/2014; 312(1):94. DOI:10.1001/jama.2014.6111 · 30.39 Impact Factor
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    ABSTRACT: The legal concept of First Person Authorization (FPA) is based on the principle that a decision by a person with decision-making capacity should be respected even after he or she dies. Although the transplant community largely supports this concept, its implementation has not been universal. We conducted a web-based survey of all 58 OPO executive directors in the U.S. to assess OPOs’ procurement policies and practices in the context of family objections. All 58 respondents (100%) responded to our survey. All OPOs except one have an online donor registration website. Most OPOs (89%) (51 of 57 respondents) estimated that the frequency of family objecting to organ donation in cases of registered donors was < 10%. No OPOs reported the frequency to be higher than 25%. Only 50% (27 of 54) of the OPOs have a written policy on handling family objections. Approximately 80% of the OPOs reported honoring FPA. However, in the past 5 years, 20 OPOs (35%) have not yet participated in organ procurement from a registered deceased donor over family objection. Further research to identify the barriers and possible solutions to implementing FPA is warranted.
    American Journal of Transplantation 01/2014; 14(1):172-177. DOI:10.1111/ajt.12519 · 6.19 Impact Factor
  • Lainie Friedman Ross, J. Richard Thistlethwaite
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    ABSTRACT: In this manuscript, we examine what role age can morally play in the allocation of deceased donor kidneys for transplantation into adult candidates. Our focus is on the equity concerns raised by recent proposals that give younger adults in end-stage renal disease priority to more and better deceased donor kidneys. We begin with a description of four models: the current allocation method (“baseline proposal”), the two models offered by the Kidney Transplant Committee in February 2011: a pure ±15 years age-matching model and a 20/80 proposal (http://optn.transplant.hrsa.gov/SharedContentDocuments/KidneyConceptDocument.PDF), and a new model entitled Equal Opportunity supplemented by Fair Innings (EOFI) described by Ross et al. earlier this year. We then consider the requirement of the National Organ Transplantation Act (NOTA) of 1984 that allocation policies balance efficiency and equity. The models all define efficiency as promoting graft and patient survival but use various conceptions of equity. We discuss the various conceptions of equity employed in the various models. We show that only the new proposal, EOFI, can meet the NOTA requirements using a multiprincipled equity approach to kidney allocation.
    Seminars in Dialysis 11/2012; 25(6). DOI:10.1111/sdi.12016 · 2.07 Impact Factor
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    ABSTRACT: Longer wait times for deceased donor kidney transplant have prompted newer initiatives to expedite the process. Reuse of a previously transplanted kidney might be appropriate in certain circumstances. However, one must also consider the unique issues that may arise after such transplants. We describe our experience in one such case where the donor kidney had lesions of focal and segmental glomerulosclerosis and signs of alloreactivity (positive C4d staining) prior to transplantation and the recipient developed ganciclovir-resistant cytomegalovirus (CMV) infection, which was perhaps transmitted from the donor. Despite the challenges, the allograft function remained stable 5 years after reuse.
    10/2012; 5(5):434-437. DOI:10.1093/ckj/sfs086
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    ABSTRACT: Testa and colleagues argue that evaluation for suitability for living donor surgery is rooted in paternalism in contrast with the evaluation for most operative interventions, which is rooted in the autonomy of patients. We examine two key ethical concepts that Testa and colleagues use: paternalism and autonomy, and two related ethical concepts: moral agency and shared decision making. We show that by moving the conversation from paternalism, negative autonomy, and informed consent to moral agency, relational autonomy, and shared decision making, one better understands why the arguments given by Testa and colleagues fail. We argue (1) why the hurdles that one must overcome to become a living donor are appropriate; and (2) that the similarities between living donor transplant surgery and cosmetic plastic surgery that the authors describe are inaccurate. Finally, we consider the recommendation to treat plastic surgery patients and living donors more similarly. We argue that any change should not be in the direction of becoming less protective of living donors, but more protective of cosmetic plastic surgery candidates.
    The Journal of clinical ethics 01/2012; 23(2):118-28. · 0.47 Impact Factor
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    Benjamin E Hippen, J Richard Thistlethwaite, Lainie Friedman Ross
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    ABSTRACT: The gap between the supply and demand of transplantable kidneys is growing, leaving policymakers eager to maximize the benefit of every kidney transplanted. Recently, a proposal for changing the way kidneys from deceased donors are allocated was proffered for public comment by the Kidney Committee of the Organ Procurement and Transplantation Network (OPTN).(1) Instead of continuing to use a patient's waiting time as the core determinant of allocation priority, the new system employs a "risk quantification score" called the Kidney Donor Profile Index (KDPI) combined with a calculated Estimated Post-Transplant Survival (EPTS) score in an attempt to quantify risk factors . . .
    New England Journal of Medicine 03/2011; 364(14):1285-7. DOI:10.1056/NEJMp1102583 · 54.42 Impact Factor
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    ABSTRACT: Influenza infection in transplant recipients is often associated with significant morbidity. Surveys were conducted in 1999 and 2009 to find out if the influenza vaccination practices in the U.S. transplant programs had changed over the past 10 years. In 1999, a survey of the 217 United Network for Organ Sharing-certified kidney and kidney-pancreas transplant centers in the U.S. was conducted regarding their influenza vaccination practice patterns. A decade later, a second similar survey of 239 transplant programs was carried out. The 2009 respondents, compared with 1999, were more likely to recommend vaccination for kidney (94.5% versus 84.4%, P = 0.02) and kidney-pancreas recipients (76.8% versus 48.5%, P < 0.001), family members of transplant recipients (52.5% versus 21.0%, P < 0.001), and medical staff caring for transplant patients (79.6% versus 40.7%, P < 0.001). Physicians and other members of the transplant team were more likely to have been vaccinated in 2009 compared with 1999 (84.2% versus 62.3% of physicians, P < 0.001 and 91.2% versus 50.3% of nonphysicians, P < 0.001). Our study suggests a greater adoption of the Centers for Disease Control and Prevention influenza vaccination guidelines by U.S. transplant programs in vaccinating solid-organ transplant recipients, close family contacts, and healthcare workers.
    Clinical Journal of the American Society of Nephrology 09/2010; 5(9):1637-41. DOI:10.2215/CJN.00150110 · 5.25 Impact Factor
  • Lainie Friedman Ross, J Richard Thistlethwaite
    New England Journal of Medicine 06/2009; 360(22):2371; author reply 2372. · 54.42 Impact Factor
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    ABSTRACT: Although CD28 blockade results in long-term cardiac allograft survival in wildtype mice, CD28-deficient mice effectively reject heart allografts. This study compared the mechanisms of allogeneic responses in wildtype and CD28-deficient mice. Adoptive transfer of purified CD28-deficient T cells into transplanted nude mice resulted in graft rejection. However, this model demonstrated that the allogeneic T cell function was severely impaired when compared with wildtype T cells, despite similar survival kinetics. Cardiac allograft rejection depended on both CD4+ and CD8+ T cell subsets in CD28-deficient mice, whereas only CD4+ T cells were necessary in wildtype recipients. These results suggested that CD8+ T cells were more important in CD28-deficient than wildtype mice. In addition to the CD8+ T cell requirement, allograft rejection in CD28-deficient mice was dependent on a sustained presence of CD4+ T cells, whereas it only required the initial presence of CD4+ T cells in wildtype mice. Taken together, these data suggest that CD4+ T cells from CD28-deficient mice have impaired responses to alloantigen in vivo, thus requiring long-lasting cooperation with CD8+ T cell responses to facilitate graft rejection. These results may help to explain the failure to promote graft tolerance in some preclinical and clinical settings.
    American Journal of Transplantation 09/2008; 1(1):38 - 46. DOI:10.1034/j.1600-6143.2001.010108.x · 6.19 Impact Factor
  • Lainie Friedman Ross, J Richard Thistlethwaite
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    ABSTRACT: In the past half-century, solid-organ transplantation has become standard treatment for a variety of diseases in children and adults. The major limitation for all transplantation is the availability of donors, and the gap between demand and supply continues to grow despite the increase in living donors. Although rare, children do serve as living donors, and these donations raise serious ethical issues. This clinical report includes a discussion of the ethical considerations regarding minors serving as living donors, using the traditional benefit/burden calculus from the perspectives of both the donor and the recipient. The report also includes an examination of the circumstances under which a minor may morally participate as a living donor, how to minimize risks, and what the informed-consent process should entail. The American Academy of Pediatrics holds that minors can morally serve as living organ donors but only in exceptional circumstances when specific criteria are fulfilled.
    PEDIATRICS 09/2008; 122(2):454-61. DOI:10.1542/peds.2008-1525 · 5.30 Impact Factor
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    ABSTRACT: A United States consensus group on the live donor concluded that minors (<18 years) can ethically serve as live solid organ donors in exceptional circumstances. More recent international guidelines reject this position. Recent United Network of Organ Sharing data show that minors serve as living donors, albeit infrequently. We examined the attitudes of US physicians toward minors as living donors. Four hundred members of the American Society of Transplantation and 160 physicians from the American Academy of Pediatrics Section of Nephrology or Bioethics were surveyed. The physicians were asked whether minors should be permitted to serve as living donors and how their opinion would change depending on the twins' zygosity, age, and increased waitlist time. One hundred seventy of 436 eligible participants (39%) returned surveys. Thirty-two and 39% of respondents would permit a kidney donation between 15-year-old fraternal and identical twins, respectively (P=NS). If the wait time increased from 1 to 6 years, willingness increased to 39% and 45%, respectively (P=NS). Pediatric bioethicists were the most reluctant to prohibit minors as living donors. Approximately one-third of US physicians would permit children to serve as donors. Lengthening the wait time is associated with a trend toward greater willingness to permit minor donations. Current policies that give preferential status for a deceased donor organ to minors may help minimize donations by their minor siblings. Nontransplant physicians need education about donor risks to ensure that donations are in the best interest of pediatric donors and recipients.
    Transplantation 06/2008; 85(9):1235-9. DOI:10.1097/01.tp.0000312675.51853.52 · 3.78 Impact Factor
  • Lainie Friedman Ross, J Richard Thistlethwaite
    American Journal of Kidney Diseases 05/2008; 51(4):545-8. DOI:10.1053/j.ajkd.2007.12.024 · 5.76 Impact Factor
  • Andrew Aronsohn, J. Richard Thistlethwaite, Donald M. Jensen, Lainie F. Ross
    Gastroenterology 04/2008; 134(4). DOI:10.1016/S0016-5085(08)63758-0 · 13.93 Impact Factor
  • Lainie Friedman Ross, Mark Siegler, J Richard Thistlethwaite
    The Hastings Center Report 01/2007; 37(6):1 p following 48. DOI:10.1353/hcr.2007.0091 · 1.08 Impact Factor
  • Lainie Friedman Ross, Stefanos Zenios, J Richard Thistlethwaite
    The Lancet 08/2006; 368(9532):333-7. DOI:10.1016/S0140-6736(06)69078-8 · 39.21 Impact Factor
  • Journal of the American College of Surgeons 07/2006; 202(6):1021-4. DOI:10.1016/j.jamcollsurg.2006.02.025 · 4.45 Impact Factor
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    Lainie Friedman Ross, J. Richard Thistlethwaite
    American Journal of Transplantation 01/2006; 6(2):436 - 436. DOI:10.1111/j.1600-6143.2005.01183.x · 6.19 Impact Factor
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    ABSTRACT: This pilot study was designed to evaluate the safety and efficacy of converting from a calcineurin inhibitor (CI) to a sirolimus (SRL)-based regimen in established renal transplant recipients with moderate renal insufficiency. Sixty renal transplant recipients on CI-based immuno-suppression with a serum creatinine (SCr) between 159 and 265 microM (1.8 and 3.0 mg/dL) and a glomerular filtration rate (GFR) between 30 and 70 mL/min were enrolled. SRL dosing was dependent upon concomitant immunosuppressive therapy. The mean patient age was 45 yr and the mean time from transplant to study enrollment was 60.8 months (range: 7-198). The median SCr was 168 microM (1.9 mg/dL) and the median GFR was 51 mL/min. Twelve months after conversion the patient and graft survival rates were 96.7% and 95%, respectively. The incidence of biopsy-proven acute rejection was 3.3% (two cases reported, Banff grades IA and IB). The median SCr and median creatinine clearance were 168 microM (1.9 mg/dL) and 53 mL/min, respectively. Hyperlipidemia, diarrhea, peripheral edema, rash, and anemia were the most commonly reported adverse events. Patients with moderate renal insufficiency can be converted from CI to SRL-based therapy and maintain renal function over a 1-yr period.
    Clinical Transplantation 03/2005; 19(1):130-6. DOI:10.1111/j.1399-0012.2004.00314.x · 1.49 Impact Factor
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    ABSTRACT: Immunohistochemical detection of the C4d complement product along peritubular capillaries (PC) may indicate humoral rejection of renal allografts. We examined the frequency of PC C4d expression in renal-allograft biopsies with acute rejection (AR) arising more than 6 months after transplantation and the impact of this finding. C4d was detected by immunoperoxidase in 2-micron paraffin sections of consecutive biopsies obtained over a 3-year period. The extent was classified as diffuse (> or =50% PC C4d+), focal (<50% C4d+), and negative (C4d-). Clinical data were obtained by retrospective chart review. Fifty-five AR episodes with Banff 97 types 1A (n = 13), 1B (n = 26), 2A (n = 11), 2B (n = 3), and 3 (n = 2) met inclusion criteria. PC C4d expression was diffuse in 23 (42%), focal in 9 (16%), and negative in 23 (42%) biopsies. AR episodes with focal and diffuse C4d expression had higher proportionate elevation of serum creatinine at biopsy and 4 weeks after diagnosis (P< or =0.05). Biopsies with diffuse PC C4d had interstitial hemorrhage (56.5%) and plasmacytic infiltrates (52%) more frequently than C4d- biopsies (22% and 16%), P = 0.02, but had no other distinctive histologic features. Graft loss was greater in diffuse (65%) compared with focal C4d+ (33%) and C4d- (33%) groups 1 year after diagnosis, P = 0.03. Other clinical and pathologic parameters did not differ significantly, including treatment received for AR. Evidence of acute cellular with occult humoral rejection is identified in more than 40% of late AR episodes. Late acute humoral rejection may be associated with interstitial hemorrhage and plasma cells and contributes significantly to graft loss.
    Transplantation 02/2005; 79(2):228-35. DOI:10.1097/01.TP.0000148987.13199.10 · 3.78 Impact Factor

Publication Stats

7k Citations
1,043.98 Total Impact Points

Institutions

  • 1985–2014
    • University of Chicago
      • • Department of Pediatrics
      • • Committee on Immunology
      • • Department of Surgery
      • • Department of Medicine
      Chicago, Illinois, United States
  • 2001
    • Emory University
      Atlanta, Georgia, United States
  • 1988–2000
    • The University of Chicago Medical Center
      • • Department of Surgery
      • • Section of Transplantation
      • • Department of Medicine
      Chicago, IL, United States
  • 1995–1999
    • Harvard University
      Cambridge, Massachusetts, United States
  • 1992–1995
    • University of Illinois at Chicago
      • • Division of Transplantation
      • • Department of Surgery (Chicago)
      Chicago, IL, United States
    • Bristol-Myers Squibb
      New York, New York, United States