M E Ioffe

The Institute for Information Transmission Problems, Moskva, Moscow, Russia

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Publications (82)55.43 Total impact

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    ABSTRACT: Early stage Parkinson's disease (PD) shares certain symptoms with essential tremor (ET), which makes it difficult to differentiate between the two. We analyzed cyclical body bends in order to find kinematic parameters that are capable of differentiating among PD, ET and normal control (NC) subjects. A linear discriminant analysis of the joint angles showed a reliable distinction between NC and the two groups of patients, while differentiating reasonably well between PD and ET. PD patients showed difficulty performing hip segment rotation around the vertical axis, whereas ET patients demonstrated enlarged torso sway in the frontal plane. These findings suggest that kinematic parameters of body movement in the standing position are sensitive enough to serve as subclinical marks in the early diagnosis of PD and ET.
    Motor control 01/2014; · 1.39 Impact Factor
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    ABSTRACT: Motor evoked potentials (MEPs) in the right first dorsal interosseous (FDI) muscle elicited by transcranial magnetic stimulation of left motor cortex were assessed in ten healthy subjects during maintenance of a fixed FDI contraction level. Subjects maintained an integrated EMG (IEMG) level with visual feedback and reproduced this level by memory afterwards in the following tasks: stationary FDI muscle contraction at the level of 40 ± 5 % of its maximum voluntary contraction (MVC; 40 % task), at the level of 20 ± 5 % MVC (20 % task), and also when 20 % MVC was preceded by either no contraction (0-20 task), by stronger muscle contraction (40-20 task) or by no contraction with a previous strong contraction (40-0-20 task). The results show that the IEMG level was within the prescribed limits when 20 and 40 % stationary tasks were executed with and without visual feedback. In 0-20, 40-20, and 40-0-20 tasks, 20 % IEMG level was precisely controlled in the presence of visual feedback, but without visual feedback the IEMG and force during 20 % IEMG maintenance were significantly higher in the 40-0-20 task than those in 0-20 and 40-20 tasks. That is, without visual feedback, there were significant variations in muscle activity due to different prehistory of contraction. In stationary tasks, MEP amplitudes in 40 % task were higher than in 20 % task. MEPs did not differ significantly during maintenance of the 20 % level in tasks with different prehistory of muscle contraction with and without visual feedback. Thus, in spite of variations in muscle background activity due to different prehistory of contraction MEPs did not vary significantly. This dissociation suggests that the voluntary maintenance of IEMG level is determined not only by cortical mechanisms, as reflected by corticospinal excitability, but also by lower levels of CNS, where afferent signals and influences from other brain structures and spinal cord are convergent.
    Experimental Brain Research 12/2013; · 2.22 Impact Factor
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    ABSTRACT: We have undertaken for the first time in this country a study of the effect of motor training under conditions of virtual reality (VR) based on the use of the PlayStation II apparatus with the input of video images via a color digital video camera and the Eye Toy Play-3 computer animation program (Sony) for the medical rehabilitation of 47 patients aged from 21 to 76 years who presented with post-stroke arm/hand paresis. The mean duration of this pathology was roughly 8 months. Each training session lasted 20-30 minutes; a total of 5 times per week were carried out during 10 days. The effect was evaluated either clinically (based on the motor assessment scale, MAS) or biomechanically with the help of the Mini Birds electromagnetic system (Ascension Technology Corporation, USA). It was shown that the application of the virtual reality technology is especially efficacious in the patients with stroke localization in the right hemisphere. It decreased the severity of paresis not only in the proximal segments of the limb but also in its distal parts (wrist). This effect can be attributed to neuroplasticity. Moreover, the training increased the accuracy of hitting the target, decreased the curvature of the trajectory of motion, and reduced the time needed to fully accomplish the task. (in Russian): Применение технологии виртуальной реальности при восстановлении движений в паретичной руке у больных, перенесших инсульт. Впервые в России проведено изучение эффекта двигательного обучения в условиях технологии виртуальной реальности (ВР). С этой целью использовали аппаратуру PlayStation II с видеовводом изображения через цветную цифровую видеокамеру и анимационную компьютерную программу Eye Toy Play-3 (фирма "Sony") для реабилитации 47 пациентов с постинсультным парезом руки в возрасте от 21 года до 76 лет, со средней давностью заболевания около 8 мес. Тренировка проводилась по 20—30 мин 5 раз в неделю, курс состоял из 10 процедур. Эффект обучения оценивался клинически (по шкале Motor Assessment Scale — MAS) и биомеханически с помощью электромагнитной системы Mini Birds ("Ascension Technology Corporation", США). Показано, что использование технологии ВР особенно эффективно у больных с локализацией очага в правом полушарии, оно способствует уменьшению степени пареза не только в проксимальных отделах руки, на тренировку которых в основном направлены игровые задания, но также и в кисти, что можно объяснить с позиции нейропластичности мозга. Кроме того, повышается точность попадания в цель, уменьшается кривизна траектории движения и снижается время, затраченное на выполнение двигательного задания в целом.
    Fizioterapiya, Bal'neologiya i Reabilitatsiya. 03/2011;
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    ABSTRACT: В первой части работы исследовали ход обучения произвольному управлению центром давлений (ЦД) у больных постинсультными гемипарезами (поражение кортико-спинальной системы), болезнью Паркинсона (поражение нигро-стриарной системы) и мозжечковыми атаксиями. Стоя на стабилографе, больные играли в две компьютерные игры, ≪Мячики≫ (М) и ≪Кубики≫ (К), в которых они должны были совмещать ЦД (курсор) с мишенью и перемещать мишень в нужное положение. В игре М мишень появлялась в неожиданных положениях, и больной обучался общей стратегии управления ЦД. В игре К больной обучался известной точной траектории перемещения ЦД. У больных обе игры были нарушены по сравнению с нормой, В течение 10 дней обучения выполнение обеих игр улучшалось по-разному в разных группах больных. Общая стратегия управления ЦД (принятие решения о направлении движения) была больше нарушена при поражении нигро-стриарной системы, а контроль точности траектории ЦД – при поражении кортико-спинальной системы. Хуже всего обеим играм обучались больные с мозжечковыми поражениями. Предполагается, что мозжечок определяет программу изменения позы, а моторная кора – контроль по обратной связи. Вторая часть работы связана с исследованием роли моторной коры в обучении бимануальной координации позы и движения (стабилизация предплечья при его разгрузке) у здорового человека. Испытуемые удерживали предплечьем правой (позной) руки груз, который фиксировался с помощью электромагнита. Разгрузка позной руки испытуемого инициировалась подъемом такого же груза левой рукой. В контрольных сериях подъем груза не приводил к разгрузке позной руки. Изменение возбудимости моторной коры исследовали методом транскраниальной магнитной стимуляции (ТМС). При повторных пробах разгрузки наблюдались прогрессивное уменьшение амплитуды движения предплечья разгружаемой руки и усиление упреждающего торможения ЭМГ бицепса разгружаемого плеча (обучение). Нормированная величина мышечного ответа на ТМС (ответ/фон) в конце обучения достоверно увеличилась. Результаты говорят о роли моторной коры в торможении мешающих синергий и координаций в процессе обучения.
    МЕХАНИЗМЫ РЕГУЛЯЦИИ ФИЗИОЛОГИЧЕСКИХ СИСТЕМ ОРГАНИЗМА В ПРОЦЕССЕ АДАПТАЦИИ К УСЛОВИЯМ СРЕДЫ, Санкт-Петербург–Колтуши; 12/2010
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    ABSTRACT: Using the transcranial magnetic stimulation (TMS) of motor cortex we examined changes in the motor evoked potential (MEP) during natural bimanual unloading, during lifting of an equivalent weight by the contralateral arm while the ipsilateral forearm was held stationary (CONTRA) and during practice of unnatural unloading. During natural unloading, MEP amplitude decreased proportionally to the muscle activity. In CONTRA task MEP amplitude decreased, but the muscle activity was not changed. It suggests that the motor cortex activity related to the "postural" arm was inhibited by the contralateral motor cortex related to the "lifting" arm. This inhibition was diminished during the unloading task. When learning the unnatural unloading, the muscle activity decreased significantly with insignificant changes of MEP amplitude. Active role of the motor cortex during learning of the new task might be related to the reduction of the contralateral inhibition. This suggestion is supported by the observation that MEP amplitude decreased stronger than muscle activity in the first learning session similar to that in CONTRA task. MEP amplitude and background activity of the muscle proportionally decreased in the last learning trial. The results show that motor cortex activity in natural and unnatural unloading task might be related to the reduction of the interhemispheric inhibition.
    Journal of Integrative Neuroscience 12/2009; 8(4):409-16. · 1.15 Impact Factor
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    ABSTRACT: There are a number of studies concerning difference of postural control following left or right hemisphere lesions. Few studies, however, compare the role of the right and left hemisphere in learning new postural tasks. This study aimed to address this question. Twenty patients with hemiparesis after ischemic stroke in the middle cerebral artery territory (11 with a right and 9 with a left hemispheric lesion) were investigated. All subjects were trained using two different tasks during ten training sessions. In both tasks, the subjects stood on a force platform and were taught to change the position of the center of pressure (COP) presented as a cursor on a monitor screen in front of the patient. The subjects were instructed to align the COP with the target and then move the target by shifting the COP in the indicated direction. In the "Balls" task, the position of the target (a ball) varied randomly, so the subject had to learn a general strategy of voluntary COP control. In "Bricks", the subject always had to move the target in a single direction (downward) from the top to the bottom of the screen, so that a precise postural coordination had to be learned. The number of correctly performed trials for a session was scored. The task performance and its rate were analyzed and compared with respect to the lesion lateralization between two patient groups. The voluntary control of the COP position and learning course were initially impaired in all groups of patients in both tasks. In "Balls", there were no differences between the two groups of patients. In contrast, in "Bricks", there was a greater initial deficit in patients with right hemisphere lesions, while the rate of postural learning and the final performance level did not differ between the groups. With a lower initial deficit and similar rate of learning, the maximal level of the task performance was reached earlier (on the 5th day of training) in patients with left hemisphere lesions. This group stopped improving its performance during follow-up training. The results suggest that the motor structures of the right hemisphere are more involved in the precise control of COP trajectory, but not in learning. There is no difference between hemispheres in the initial performance and learning of the general strategy of voluntary COP control. Possibly, the control of specific COP trajectory needs more sensory feedback that is associated with greater involvement of the right hemisphere. This might be a reason for the greater initial impairment of this task after lesions in the right hemisphere.
    Experimental Brain Research 12/2009; 201(4):753-61. · 2.22 Impact Factor
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    ABSTRACT: Several studies on mice have demonstrated a correlation between the concentrations of dopamine and its metabolites in the nucleus accumbens and asymmetry in forelimb preference. Dopamine concentrations were greater in the nucleus accumbens ipsilateral in relation to the preferred paw. Limb preference was demonstrated in rats during performance of a response consisting of withdrawing food from a horizontal tube. Brain tissue dopamine concentrations were estimated by high-performance liquid chromatography with electrochemical detection. The results showed that in "left-handed" rats, the dopamine concentration in the left nucleus accumbens was significantly greater than that in "right-handed" rats. In right-handed rats, the dopamine concentration in the right nucleus accumbens was greater than that in the left. The results obtained here are significantly consistent with data obtained in mice and support the suggestion that the dopamine level in rats is greater in the nucleus accumbens ipsilateral to the preferred limb.
    Neuroscience and Behavioral Physiology 12/2008; 38(9):991-4.
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    ABSTRACT: Anticipatory postural adjustment (APA) during bimanual action is observed when participants hold an object in one hand and then lift that object with the other hand. The decrease in activity of a forearm flexor muscle prior to an active forearm unloading acts to stabilize the forearm position. Recent studies have investigated the influence of the corticospinal system on muscle activity during APA through transcranial magnetic stimulation. It was shown that at different times during APA, the amplitude of motor-evoked potentials in the forearm flexors decreased in conjunction with the decrease of muscle activity. If the unloading is triggered via an electromagnet by lifting an equal weight by the other arm, the anticipatory postural adjustment is learned through the repetition of unloading (three series of 20 trials). Using the transcranial magnetic stimulation, we examined changes in the motor-evoked potential in the forearm flexors before and after APA learning. Motor-evoked potential amplitude did not significantly change as forearm flexor activity decreased. The motor-evoked potential/background electromyogram ratio, however, increased in the final learning session in comparison to the initial learning session and stationary loading. The present results corroborate a hypothesis on the fundamental role of the motor cortex in the suppression of synergies that interfere with the execution of the new coordination in the process of motor learning.
    Experimental Brain Research 04/2008; 186(2):215-23. · 2.22 Impact Factor
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    ABSTRACT: The role of the motor cortex in forming a learned coordination (stabilization of the forearm on unloading) was studied in humans. Subjects maintained a 1-kg weight with the right (postural) forearm, the weight being attached via an electromagnet. Unloading of the postural arm was initiated by the subjects by lifting a similar load with the left arm. In control experiments, lifting of the load did not lead to unloading of the postural arm. Changes in motor cortex excitability were studied by transcranial magnetic stimulation applied to the representation area of the right biceps muscle in the motor cortex at the beginning and end of the experiments. Repeated unloading tests showed progressive decreases in the amplitude of the movement of the unloaded forearm, which were accompanied by increases in the anticipatory inhibition of the electromyogram of the biceps muscle of the unloaded arm (learning). Muscle responses to transcranial magnetic stimulation during the learning process showed no significant changes. Analysis of normalized muscle responses to transcranial magnetic stimulation (response/baseline) showed that these increased at the end of training and reached a significantly higher level than seen at the beginning of training. These results lead to the conclusion that the motor cortex plays a fundamental role in inhibiting synergies and coordinations which would interfere with the formation of the new coordination during motor learning.
    Neuroscience and Behavioral Physiology 10/2007; 37(7):651-7.
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    ABSTRACT: For a long time, the cerebellum has been known to be a structure related to posture and equilibrium control. According to the anatomic structure of inputs and internal structure of the cerebellum, its role in learning was theoretically reasoned and experimentally proved. The hypothesis of an inverse internal model based on feedback-error learning mechanism combines feedforward control by the cerebellum and feedback control by the cerebral motor cortex. The cerebellar cortex is suggested to acquire internal models of the body and objects in the external world. During learning of a new tool the motor cortex receives feedback from the realized movement while the cerebellum produces only feedforward command. To realize a desired movement without feedback of the realized movement, the cerebellum needs to form an inverse model of the hand/arm system. This suggestion was supported by FMRi data. The role of cerebellum in learning new postural tasks mainly concerns reorganization of natural synergies. A learned postural pattern in dogs has been shown to be disturbed after lesions of the cerebral motor cortex or cerebellar nuclei. In humans, learning voluntary control of center of pressure position is greatly disturbed after cerebellar lesions. However, motor cortex and basal ganglia are also involved in the feedback learning postural tasks.
    The Cerebellum 02/2007; 6(1):87-94. · 2.60 Impact Factor
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    ABSTRACT: A number of published studies reported a correlation between the paw preference in mice and asymmetry of tissue concentrations of dopamine (DA) and DA metabolites measured in the nucleus accumbens (NAcb) the DA concentration being higher in the nucleus ipsylateral to a preferred paw. This study aimed to investigate whether such asymmetry existed in rats. The paw preference was defined by reaching into a small horizontal tube for a food pellet. Tissue concentration of DA was measured by high-performance liquid chromatography with electrochemical detection. It was shown that the DA concentration in the left NAcb was significantly higher in "left-handed" rats than in "right-handed" animals. Within the group of "right-handers", the DA concentration was significantly higher in the right NAcb than in the left NAcb. The results confirm in part the experimental data obtained in mice and support the hypothesis that the paw preference is paralleled by elevated tissue DA in the ipsylateral NAcb of rodents.
    Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 01/2007; 57(5):598-603. · 0.25 Impact Factor
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    ABSTRACT: The aim of the present work was to study the effects of training on the restoration of a lateralized motor skill (a food-procuring forelimb movement) in Wistar rats (n = 83) after lesioning of the caudate nucleus in conditions of infrequent testing and intensive retraining. On the basis of the training results, the rats were divided into those preferring the right (right-handers) or left (left-handers) limb. Testing was followed by lesioning of the head of the caudate nucleus on the side contralateral to the preferred paw. Animals with identical initial preferences were then divided into two groups: an infrequently tested group in which recovery of the skill was tested once weekly for five months, and an intensive retraining group, in which experiments were performed 3-4 times weekly, again for five months. After surgery, animals had to perform the food-procuring skill only with the "impaired" paw. Differences in the recovery of the skill were seen in animals with different limb preferences both in conditions of spontaneous recovery and in those recovering with training. Overall, animals with lesions of the left caudate nucleus (right-handers) showed better recovery than animals with lesions of the right caudate nucleus (left-handers) in both spontaneous recovery and in recovery with training. These findings suggest that the central neural mechanisms of recovery of a lateralized motor skill after unilateral lesioning of the caudate nucleus are different after lesions to the right and left hemispheres.
    Neuroscience and Behavioral Physiology 11/2006; 36(8):897-900.
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    ABSTRACT: The responses of the biceps brachii muscle of the upper arm to magnetic stimulation of the motor cortex during the postural pretuning and forearm unloading tasks were studied in humans. On active unloading, the amplitude of the evoked response decreased in parallel with a decrease in muscle activity. During stationary holding of the load, the muscle response changed in proportion to the load. When, on the background of stationary holding of the load, the other arm took on the same load, the amplitude of the evoked response in the biceps muscle of the arm holding the load decreased without any change in the muscle activity. Passive unloading was accompanied by similar changes in the response evoked by magnetic stimulation as seen with active unloading. The question of whether the decrease in muscle activity (postural pretuning) in active unloading may be associated with both direct corticospinal influences and influences mediated via subcortical structures is discussed.
    Neuroscience and Behavioral Physiology 03/2006; 36(2):177-83.
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    ABSTRACT: Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subjects. The subjects stood on a force platform and were trained to change the position of the center of pressure (CP) presented as a cursor on a monitor screen in front of the patient. Subjects were instructed to align the CP with the target and then move the target by shifting the CP in the indicated direction. Two different tasks were used. In "Balls", the target (a ball) position varied randomly, so the subject learned a general strategy of voluntary CP control. In "Bricks", the subject had to always move the target in a single direction (downward) from the top to the bottom of the screen, so that a precise postural coordination had to be learned. The training consisted of 10 sessions for each task. The number of correctly performed trials for a session (2 min for each task) was scored. The voluntary control of the CP position was initially impaired in all groups of patients in both tasks. In "Balls", there were no differences between the groups of the patients on the first day. The learning course was somewhat better in hemiparetic patients than in the other groups. In "Bricks", the initial deficit was greater in the groups of parkinsonian and cerebellar patients than in hemiparetic patients. However, learning was more efficient in parkinsonian than in hemiparetic and cerebellar patients. After 10 days of training, the hemiparetic and cerebellar patients completed the acquisition at a certain level whereas the parkinsonian patients showed the ability for further improvement. The results suggest that motor cortex, cerebellum, and basal ganglia are involved in voluntary control of posture and learning different postural tasks. However, these structures play different roles in postural control and learning: basal ganglia are mainly involved in learning a general strategy of CP control while the function of the motor cortex chiefly concerns learning a specific CP trajectory. The cerebellum is involved in both kinds of learning.
    Experimental Brain Research 02/2006; 168(3):384-94. · 2.22 Impact Factor
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    ABSTRACT: The postural sway biofeedback is based on constant monitoring of patient’s pressure center position (CP). Patient gets the possibility to learn of voluntary displacement of CP with the different amplitude, speed, accuracy, and direction during special computer games. The aim of this study is to determine the effect of the postural sway biofeedback on the upright posture stability in patients with poststroke hemiparesis (PH), Parkinson’s disease (PD), and spinocerebellar ataxia (SCA). A total of 187 patients including 57 patients with PH, 76 with prevalence of rigidity and hypokinesia forms of idiopathic PD, and 57 with SCA were investigated. All patients were randomly divided into two groups: the basic group of 148 patients who received complex therapy enclosed the postural sway biofeedback and the control group of 39 patients who did not receive the postural sway biofeedback. The patients stood on a force platform and learned to control position of CP with visual feedback during the special computer games. A daily session lasted 15 min. The balance training consisted of 10 sessions. The patients of the basic group demonstrated more significant improvement of their postural stability. There was also a more significant improvement of attention concentration, mental neurodynamics processes and positive changes in the emotional and will spheres. Results suggest that postural disorders in the patients with PH, PD, and SCA can be reduced as a result of the biofeedback postural sway training. They also indicated that the including of the balance training in rehabilitation programs improves the cognitive and emotional state of the patients.
    Applied Psychophysiology and Biofeedback 12/2005; 30(4):402-403. · 1.13 Impact Factor
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    ABSTRACT: Transcranial magnetic brain stimulation (TMS) was used to assess the influence of the corticospinal system on motor output during forearm unloading in humans. Unloading was obtained either "passively" by the experimenter, or "actively" with the subjects' own contralateral arm. Anticipatory postural adjustments consisted of changes in the activity of a forearm flexor muscle prior to active unloading of the limb and acted to stabilize the forearm position. Motor evoked potentials (MEPs) were recorded in the forearm flexor at different times during active and passive unloading, static forearm loading, and during lifting of an equivalent weight by the contralateral arm while the ipsilateral forearm was statically loaded and held stationary. In active unloading, MEP amplitude decreased with the decrease of muscle activity. Passive unloading resulted in a similar decrease of MEP as with active unloading. During stationary forearm loading, the change in MEP corresponded to the degree of loading. If during static loading the contralateral arm has lifted a separate, equivalent weight, the amplitude of MEP decreased. A possible role of direct corticospinal volley and the motor command mediated by subcortical structures in anticipatory postural adjustments is discussed.
    Neuroscience Letters 09/2005; 383(3):246-50. · 2.03 Impact Factor
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    ABSTRACT: The role of the prefrontal cortex was studied in an active selection situation in which dogs had to choose one of two feeders, with changes in the quality and probability of the reinforcement provided in one of the feeders. The study was performed in two stages. Before surgery, animals were trained to place themselves on a start area during the interstimulus interval. Dogs were presented with a conditioned stimulus for investigation of the sequence of selection of feeders with identical reinforcements. After bilateral extirpation of the prefrontal areas (the proreal gyrus), dogs continuously ran from one feeder to the other during the interstimulus period. In response to the conditioned stimulus, the animals repeated the reaction of selecting the same feeder on many occasions during the first few (7-9) days. When there was a conflict between the probability and quality of reinforcement, the dogs came to prefer the feeder with the greater reinforcement quality despite its lower probability of presentation. In our experiments, operated animals presented with food at probabilities of 30% and 100% performed feeder selections with different probabilities. One of the functions of the prefrontal cortex in intact animals would appear to be to support the reaction of selecting the greater probability of reinforcement.
    Neuroscience and Behavioral Physiology 07/2005; 35(5):525-34.
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    ABSTRACT: One hundred sixty-seven patients with impaired balance control were taught to control position of the center of pressure (CP) with visual feedback during several computer games. The study revealed that postural disorders in the patients with some neurological diseases can be reduced as a result of the feedback postural sway training. Objective: The aim of this study is to determine the effect of the postural sway feedback on the upright posture stability in patients with poststroke hemiparesis (PH), Parkinson’s disease (PD) and spinocerebellar ataxia (SCA). Participants: A total 167 patients including 55 patients with PH, 56 patients with idiopathic PD (prevalence of rigidity and hypokinesia) and 56 patients with SCA were investigated. All patients were randomly divided into two groups: the basic group of 148 patients who received complex therapy including postural sway feedback training and the control group of 39 patients who did not train the postural sway feedback. Method: The patients stood on a force platform and learned to control position of CP with visual feedback during several computer games. A daily session lasted 20 min. The balance training consisted of 10 sessions. Results: The patients of the basic group improved their postural stability significantly more than the patients of the control group. Conclusion: The results suggest that postural disorders in the patients with PH, PD and SCA can be reduced by biofeedback postural sway training. They also indicated that the including of the balance training in rehabilitation programs improves the cognitive and emotional state of the patients.
    Applied Psychophysiology and Biofeedback 06/2005; 30(2):164-165. · 1.13 Impact Factor
  • Gait & Posture - GAIT POSTURE. 01/2005; 21.
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    ABSTRACT: Introduction: Feedback training is an efficient way of posture rehabilitation. The relevant studies concern poststroke patients [1]. The present study investigates the effects of learning postural tasks on postural stability in patients with poststroke hemiparesis (PH), Parkinson's disease (PD) and cerebellar ataxia (CA). Methods: 20 PH patients, 21 PD patients and 25 CA patients were investigated. The subjects stood on a force platform. The center of pressure (CP) was presented as a cursor on the monitor. The initial body stability during quiet standing and maximum CP displacements during trunk bending in sagittal and frontal planes were recorded. Then the subjects had to align the cursor with the target on the screen and to move the CP whereby the target shifted towards a new position. Two different tasks were used. A daily session lasted 2 min for each task. Duration of the training was 10 days. A control group consisted of 12 PH patients, 15 PD patients and 12 CA patients. Results: After training the square of the CP displacement during quiet standing decreased and the CP amplitude during bending in both sagittal and frontal planes increased in hemiparetic patients as compared with the control group. The PD and cerebellar patients revealed increase of the bending in sagittal and frontal planes, correspondingly. Conclusion: The feedback training improves postural stability in the patients with poststroke hemiparesis, Parkinson's disease and cerebellar ataxia.
    Gait & Posture 01/2005; 21. · 1.97 Impact Factor

Publication Stats

318 Citations
55.43 Total Impact Points

Institutions

  • 2013
    • The Institute for Information Transmission Problems
      Moskva, Moscow, Russia
  • 1987–2013
    • Russian Academy of Sciences
      • • Institute of Higher Nervous Activity and Neurophysiology
      • • Institute of Problems of Information Transmission
      Moskva, Moscow, Russia
  • 2003
    • Russian Academy of Medical Sciences
      Moskva, Moscow, Russia