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ABSTRACT: To clarify the change of serum thyroid hormone levels during perioperation period of coronary artery bypass grafts (CABG).
The levels of serum thyroid hormones (TT(3), TT(4), FT(3), FT(4), TSH, rT(3)) were measured by chemical-luminal and RIA in 62 patients at certain time in perioperation period, as well as 30 normal volunteers on a fasting basis. SPSS 10.0 was used for statistic analysis.
The levels of serum thyroid hormones had no significant difference between controls and patients before CABG. At 10 min and 60 min after giving heparin, serum TT(4), FT(4) levels in patients during operation elevated significantly than before (P < 0.01), however, at 2 h after operation, serum TT(3), TT(4), FT(3), FT(4), rT(3), TSH levels had no significant changes. Serum TT(3), TT(4), FT(3), FT(4), TSH levels at 24 h and 72 h after operation were significantly lower in patients than before CABG (P < 0.01). Especially at 24 h, serum TT(3), FT(3) levels decreased by 52.7% and 46.6% than before respectively, while serum rT(3) levels increased significantly (P < 0.01) and serum TT(3), rT(3) levels decreased significantly (P < 0.01). The serum TT(4), FT(3), FT(4), TSH levels didn't return to normal at 7 d after operation.
Elevated serum TT(4), FT(4) levels are present in acute period in patients accepted CABG. Decreased serum T(3) and FT(3) levels after CABG may indicate a bad prediction.
Zhonghua yi xue za zhi 10/2009; 89(39):2783-5.