Publications (2)4.08 Total impact
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Article: Ultrasensitive Real-Time PCR for the Clinical Management of Visceral Leishmaniasis in HIV-Infected Patients.
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ABSTRACT: Molecular methods have been proposed as an alternative tool for the diagnosis of visceral leishmaniasis (VL), but no data are available regarding use for monitoring clinical outcome. A prospective cohort study of human immunodeficiency virus-(HIV) and VL-coinfected patients was conducted in a university-affiliated hospital in Barcelona, Spain. Leishmania parasite load was monitored using a real-time polymerase chain reaction (PCR) at baseline and every 3 months. Cutoff values for PCR were determined using receiver operating characteristic (ROC) curves. Overall, 37 episodes were analyzed, and 25 of these episodes were considered as relapsing episodes. A significant decrease of parasite load measured 3 months after treatment could predict the clinical evolution of VL. A parasite load over 0.9 parasites/mL measured 12 months after treatment could predicts relapse with a sensitivity of 100% and a specificity of 90.9%. Monitoring parasite load by an ultrasensitive quantitative Leishmania PCR is useful to predict the risk of relapse after a VL episode in HIV-infected patients.The American journal of tropical medicine and hygiene 04/2013; · 2.59 Impact Factor -
Article: [Tenofovir associated hypokalaemia in a patient with normal renal function].
Enfermedades Infecciosas y Microbiología Clínica 04/2010; 28(9):655-6. · 1.49 Impact Factor
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Institutions
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2010
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Hospital Universitari Vall d'Hebron
Barcelona, Catalonia, Spain
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