Mohamed Aggag

Children's Cancer Hospital Egypt, Al Qāhirah, Al Qāhirah, Egypt

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Publications (4)7.5 Total impact

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    ABSTRACT: NTRODUCTION: As Central Nervous System tumors account for second most common childhood malignancies, improving treatment modalities can lead to increase the survival rate of patients. The epidemiological investigations make a large-scale database of analysis for prognostic features of this group. In this study, we examined the epidemiology of childhood brain tumors in patients who referred to MPCTRC (one of the main national referral centers for childhood malignancies in Iran) for treatment. MATERIAL & METHOD: This cohort (simple sampling) study consisted of 198 children less than 15 years old with CNS tumor who referred to MPCTRC since 2007 to 2010. The unique checklist contained epidemiological features filled for each individual. Data analyzed by SPSS version 19 with Kolmogorov-Smirnov and Chi square tests. RESULTS: Out of enrolled patients 125(63.1%) male and 73(36.9%) female, had the mean age of 6.11 ± 3.65 years old. Tumors located in supratentorial (N = 60, 30.3%), infratentorial (N = 134, 67.7%) and spinal (N = 4, 2%). High-grade glioma and medulloblastoma were the most tumors in supratentorial and infratentorial locations respectively. The majority of patient's stage in medulloblastoma group was T2M0 (N = 44, 22.2%). The most clinical findings were vomiting, headache and impaired vision respectively. Thirty-one (15.7%) patients had relapse. there were 76(38.4%) off treatment and 82 (41.4%) death. The five years survival rate was 36%. CONCLUSION: According to the similar previously studies, the epidemiological features are same but the survival rate in this investigation was lower. Therefore, cautious interpretation in the future's investigations is undesirable. Brain tumor-based approach can lead to determine better treatment modalities for increasing cancer burden in pediatric malignancies.
    Neuro-Oncology. 06/2012; 14(suppl 1):i106-i110.
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    ABSTRACT: Super paramagnetic iron oxide Fe(3)O(4) nanoparticles prepared via photochemical reaction in pure form were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice. Our results indicate that the mean temperature profiles at the rectum, periphery of the tumor surface and at the center of the tumor during hyperthermia treatment increased gradually. The maximum temperature achieved in the tumor center was 47±1°C after 20 min with radiofrequency exposures at 25 kW. The acquired magnetic resonance images identified apoptotic cells in the center of the tumor which were exposed to magnetic resonance hyperthermia (MRH). Apoptotic cells presented as dark signal intensity in the T(1)-weighted images which were further confirmed by pathological examinations. Also, the results revealed that the tumor size in the all mice exposed to MRH is still as the same as before the treatment, but the rate of tumor growth was very slow by comparing with the growth rate of the control group.
    Magnetic Resonance Imaging 02/2011; 29(2):272-80. · 2.06 Impact Factor
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    ABSTRACT: The current radiofrequency ablation technique requires invasive needle placement. On the other hand, most of the common photothermal therapeutic methods are limited by lack of accuracy of targeting. Gold and magnetic nanoparticles offer the potential to heat tumor tissue selectively at the cellular level by noninvasive interaction with laser and radiofrequency. Gold nanospheres and gold-coated magnetic nanocomposites were used for inducing hyperthermia to treat subcutaneous Ehrlich carcinoma implanted in female mice. In mice treated with gold nanospheres, tumors continued to grow but at a slow rate. In contrast, more than 50% of the tumors treated with gold-coated magnetic nanocomposites completely disappeared. This simple and noninvasive method shows great promise as a technique for selective magnetic photothermal treatment.
    International Journal of Nanomedicine 01/2011; 6:2155-65. · 4.20 Impact Factor
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    ABSTRACT: In neurosurgery, ultrasound is useful in determination of the tumor location, differentiation between solid tumors and cystic components, as well as definition of the shortest and safest access to the mass. This study aims to evaluate the role of the intraoperative ultrasound in resection of pediatric brain tumors. Intraoperative ultrasonography (conventional B-Mode) was performed in 25 pediatric patients with brain tumors pre-, during, and post-resection, in whom eight patients were supratentorial and 17 were infratentorial. Post-op Grayscale images of the brain tumors on conventional ultrasound were compared with the results of immediate postoperative magnetic resonance imaging. The border of the tumor and post-resection residual tumor were more distinguishable from healthy brain on ultrasound during the operation. Improved definition of the tumor tissue from normal brain with ultrasound was demonstrated in all cases aiding in tumor resection. Intraoperative ultrasound is suggested to be a useful imaging technique in defining the border between the tumor and healthy brain tissue pre-resection, in detecting residual tumor tissues after the resection of the mass, and in guiding to the shortest and safest access to the tumor during neurosurgery.
    Child s Nervous System 02/2010; 26(9):1189-93. · 1.24 Impact Factor