Guoping Fu,
Yuhong Chen,
Mei Yu, Andy Podd,
James Schuman,
Yinghong He,
Lie Di,
Maryam Yassai,
Dipica Haribhai,
Paula E. North,
Jack Gorski,
Calvin B. Williams,
Demin Wang,
Renren Wen
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ABSTRACT: Phospholipase Cγ1 (PLCγ1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCγ1 in
T cell biology, we generated and examined mice with T cell–specific deletion of PLCγ1. We demonstrate that PLCγ1 deficiency
affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs
TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-κB. Importantly, PLCγ1
deficiency impairs the development and function of FoxP3+ regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCγ1 is essential for T cell development, activation,
and tolerance.
Journal of Experimental Medicine 02/2010; 207(2):309-318. · 13.85 Impact Factor