Andy Podd

Publications (2)27.71 Total impact

• Source

  Available from: Dipica Haribhai

  Article: Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance.

  Guoping Fu, Yuhong Chen, Mei Yu, Andy Podd, James Schuman, Yinghong He, Lie Di, Maryam Yassai, Dipica Haribhai, Paula E North, Jack Gorski, Calvin B Williams, Demin Wang, Renren Wen
  [show abstract] [hide abstract]
  ABSTRACT: Phospholipase Cgamma1 (PLCgamma1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCgamma1 in T cell biology, we generated and examined mice with T cell-specific deletion of PLCgamma1. We demonstrate that PLCgamma1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-kappaB. Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance.
  Journal of Experimental Medicine 02/2010; 207(2):309-18. · 13.85 Impact Factor
• Source

  Available from: jem.highwire.org

  Article: Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

  Guoping Fu, Yuhong Chen, Mei Yu, Andy Podd, James Schuman, Yinghong He, Lie Di, Maryam Yassai, Dipica Haribhai, Paula E. North, Jack Gorski, Calvin B. Williams, Demin Wang, Renren Wen
  [show abstract] [hide abstract]
  ABSTRACT: Phospholipase Cγ1 (PLCγ1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCγ1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLCγ1. We demonstrate that PLCγ1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-κB. Importantly, PLCγ1 deficiency impairs the development and function of FoxP3+ regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCγ1 is essential for T cell development, activation, and tolerance.
  Journal of Experimental Medicine 02/2010; 207(2):309-318. · 13.85 Impact Factor