Publications (2)0.52 Total impact
Article: Successful management of congenital chylous ascites in a premature infant using somatostatin analogue.[show abstract] [hide abstract]
ABSTRACT: Congenital chylous ascites (CCA) is a rare disease defined as the accumulation of chylomicron-rich lymphatic fluid within the peritoneal cavity, resulting from maldevelopment of the intra-abdominal lymphatic system. Cases unresponsive to conservative treatment usually require surgical intervention. We report a case of CCA in a premature neonate, who was treated successfully with intravenous infusion of octreotide, a synthetic somatostatin analogue after failure to response to traditional supportive therapies.The Indian Journal of Pediatrics 10/2010; 78(3):345-7. · 0.52 Impact Factor
Article: Impaired growth hormone receptor signaling during non-catch-up growth in rats born small for gestational age.[show abstract] [hide abstract]
ABSTRACT: Non-catch-up growth (NCG) in children born small for gestational age (SGA) is associated with growth hormone (GH) resistance, although the mechanisms of this association are unknown. Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling is involved in GH signal transduction. This study examined the role of JAK/STAT signaling in GH resistance of SGA rats. NCG-SGA was induced by uterine artery ligation in pregnant rats. NCG-SGA rats were treated with GH for 7 days and rats appropriate for gestational age (AGA) served as controls. Phosphorylation of JAK2/STAT5 and expression of GH receptor, suppressor of cytokine signaling 2 (SOCS-2) and cytokine-inducible SH2-containing protein (CIS) in the liver were determined by Western blotting. The expression of insulin-like growth factor 1 (IGF-1) mRNA was examined by the reverse transcription-polymerase chain reaction. GH treatment significantly increased body weight and length growth rate in AGA but not in NCG-SGA rats. The increase in serum IGF-1 level and expression of IGF-1 mRNA in response to GH treatment in NCG-SGA rats was significantly less than in AGA rats. GH-induced increase in phosphorylation of JAK2/STAT5 in response to acute GH stimulation was significantly lower in NCG-SGA rats compared to AGA controls. SOCS-2 and CIS expressions significantly increased in NCG-SGA rats following GH treatment. GH resistance in NCG-SGA rats is associated with impaired JAK/STAT signaling and upregulated SOCS-2 and CIS expression.Hormone Research in Paediatrics 01/2010; 74(2):106-13.