María Sabater

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Publications (2)9.61 Total impact

  • Article: Hypertrophic cardiomyopathy or storage cardiomyopathy? Role of genetics to predict outcome.
    Maria J Oliva-Sandoval, Carmen Muñoz-Esparza, Esperanza García-Molina, María Sabater, Juan R Gimeno, Mariano Valdés
    International journal of cardiology 07/2011; 151(3):380-1. · 7.08 Impact Factor
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    Article: Characteristics of sudden death in inherited heart disease.
    Juan R Gimeno, María J Oliva, Javier Lacunza, Arcadi G Alberola, María Sabater, Juan Martínez-Sánchez, Daniel Saura, Antonio Romero, Mariano Valdés
    [show abstract] [hide abstract]
    ABSTRACT: Cardiomyopathy and channelopathy are major causes of sudden death (SD). The little information available on the context in which SD occurs has come from only a few referral centers. The objective was to investigate the circumstances surrounding SD in families with inherited heart disease. The study included 152 SD patients (mean age 43+/-19 years) from 103 families. The reasons for inclusion were resuscitated SD in 7%, recent SD in 8%, and a diagnosis of cardiomyopathy or channelopathy in a living relative in 72%. Also, 13% were athletes. Family trees were constructed and each death's circumstances were recorded. Autopsy and medical records were reviewed. Overall, 18% of SDs occurred during physical exercise, 32% during normal daily activities, and 37% during rest or sleep. There was a significant association between male sex and SD: 111 males (73%) vs. 41 females (27%; P=.03). Exercise-related SD was associated with young age (P=.01). The percentage of SDs associated with exercise, stress or normal daily activities was significantly greater with cardiomyopathy than channelopathy (61% vs. 41%; P=.057). All athletes were male and the majority died during exercise (50% vs. 11% of non-athletes; P=.0002). Patients with Brugada syndrome had the highest percentage of SDs during rest or sleep (i.e. 47%). No clear trigger could be identified in 33%. SD was common in inherited heart disease, which accounted for a significant number of cases. Males clearly predominated over females (ratio 3:1) among SD cases (irrespective of pathological type). Most SDs occurred during exercise or normal daily activities in cardiomyopathies and during rest or sleep in channelopathies. The percentage of exercise-related SDs (i.e. 18%) was higher than expected.
    Revista Espa de Cardiologia 03/2010; 63(3):268-76. · 2.53 Impact Factor
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