Publications (4)2.99 Total impact
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Article: Verbascoside is not genotoxic in the ST and HB crosses of the Drosophila wing spot test, and its constituent, caffeic acid, decreases the spontaneous mutation rate in the ST cross.
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ABSTRACT: Verbascoside (VB) is a phenylpropanoid isolated from Buddleja species, some of which originate in Mexico, and was first described in the sixteenth century in the codices of Mexican traditional medicine. VB is present in alcohol extracts and is widely used in the north of Mexico as a sunscreen. VB absorbs UV-A and UV-B radiation and has high antioxidant and anti-inflammatory capacities. VB and its constituent caffeic acid (CA) were screened to determine their genotoxic activity using the Drosophila wing spot test. Third instar larvae (72±4 h) of the standard (ST) and high bioactivation (HB) crosses, with regulated and high levels of cytochrome P450s (Cyp450s), respectively, were exposed to VB or CA (0, 27, 57, 81, 135, and 173 mM). VB was not genotoxic at any of the concentrations tested in both crosses. The amount of VB residue as determined by HPLC in the adult flies that were fed with VB indicated a low metabolism of this compound, which explains the absence of genotoxicity. CA decreased the spontaneous frequencies of small and total spots and showed putative toxicity in the ST cross.Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 12/2011; 50(3-4):1082-90. · 2.99 Impact Factor -
Article: Photoprotective activity of Yucca periculosa polyphenols
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ABSTRACT: The aim of this work was to investigate the potential utility of the methanolic extract of the bark of Yucca periculosa, as well as trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene (MS), resveratrol, and naringenin for their potential as photochemopreventive agents. All substances have photoprotective effect against UV-B induced cell death in Escherichia coli, with MS and resveratrol showing the highest photoprotective properties. The sun protection factor (SPF) of the substances was evaluated by a guinea pig bioassay and a histopathological skin study. All substances prevented skin damage induced by UV and have an SPF higher than the octyl methoxycinnamate (OMC) a commercial sunscreen. The results showed the trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene isolated from Y. periculosa may afford substantial protection against the damages caused by UV exposure.Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas. 01/2010; -
Article: Ent-labdane type diterpene with antifungal activity from Gymnosperma glutinosum (Spreng.) Less. (Asteraceae)
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ABSTRACT: The aim of this work was to isolate and identify the antifungal compounds present in the hexanic extract of the aerial parts of Gymnosperma glutinosum. The antifungal activity against six pathogenic fungi was determined in accordance with the inhibition of radial growth method. Four of those fungi Aspergillus niger, Candida albicans, Fusarium sporotrichum and Trichophyton mentagrophytes are of clinical importance and two fungi Fusarium moniliforme and Rhyzoctonia solani are of agricultural importance. The bioassay-guide purification of the methanolic partition (from hexanic extract) resulted in the isolation and identification of three antifungal compounds an ent-labdane type diterpene and two methoxylated flavones, as the metabolites responsible for activity.Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas. 01/2009; -
Article: Ent-labdane type diterpene with antifungal activity from Gymnosperma glutinosum (Spreng.) Less. (Asteraceae) (Diterpeno tipo Ent-labdano con actividad fungicida aislado de Gymnosperma glutinosum (Spreng.) Less. (Asteraceae))
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ABSTRACT: The aim of this work was to isolate and identify the antifungal compounds present in the hexanic extract of the aerial parts of Gymnosperma glutinosum. The antifungal activity against six pathogenic fungi was determined in accordance with the inhibition of radial growth method. Four of those fungi Aspergillus niger, Candida albicans, Fusarium sporotrichum and Trichophyton mentagrophytes are of clinical importance and two fungi Fusarium moniliforme and Rhyzoctonia solani are of agricultural importance. The bioassay-guide purification of the methanolic partition (from hexanic extract) resulted in the isolation and identification of three antifungal compounds an ent-labdane type diterpene and two methoxylated flavones, as the metabolites responsible for activity.
