Liaosheng Zhou

Publications (3)7.27 Total impact

• Article: Prostaglandin E1 dose-dependently promotes stability of atherosclerotic plaque in a rabbit model.

  Wanjun Bai, Xue Zheng, Liaosheng Zhou, Hongjian Li
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  ABSTRACT: This study evaluated the effect of prostaglandin E1 (PGE1) on the stability of atherosclerotic plaque. A vulnerable plaque model was established in rabbits, using balloon injury combined with a high-cholesterol diet. The rabbits were distributed into a control group, a low-dose PGE1 treatment group, a moderate-dose PGE1 treatment group, a high-dose PGE1 treatment group, and a simvastatin treatment group, with treatments lasting for 4 weeks. At week 13 (at the end of the experiments), atherosclerotic plaque was triggered by injection of Russell's viper venom (Chinese) and histamine. Serological, pathological, immunohistochemical, and gene-expression studies were subsequently performed. PGE1 treatment did not alter serum lipid levels; however, PGE1 dose-dependently increased the thickness of the fibrous caps, and decreased the plaque vulnerability index. The plaque contents of macrophage- and the mRNA levels of monocyte-chemotactic protein-1, matrix metalloproteinase-1, and matrix metalloproteinase-9 were markedly reduced in all of the PGE1 treatment groups, with the high-dose of PGE1 being more effective than the simvastatin treatment. These findings suggest that PGE1 dose-dependently enhances the stability of atherosclerotic plaque. The high-dose of PGE1 presented more protection in terms of inhibiting macrophage accumulation and inflammatory expression in plaque. Our findings suggest a novel drug for the treatment of atherosclerosis.
  Canadian Journal of Physiology and Pharmacology 02/2012; 90(2):131-9. · 1.95 Impact Factor
• Article: Effect of prostaglandin E1 on TNF-induced vascular inflammation in human umbilical vein endothelial cells.

  Wentong Fang, Hongjian Li, Liaosheng Zhou, Lequn Su, Ying Liang, Yan Mu
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  ABSTRACT: Prostaglandin E1 (PGE1) is a member of the prostaglandins and has a variety of cardiovascular protective effects. Increasing attention has been paid to the anti-inflammation activity of PGE1, but little direct evidence has been found. We investigated the effects of PGE1 on cell adhesion and inflammation and the mechanisms responsible for this activity in tumor necrosis factor (TNF)-treated human umbilical vein endothelial cells. Results demonstrated that pretreatment with PGE1 decreased the adhesion between vascular endothelial cells and monocytes, reduced the expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in vascular endothelial cells. In addition, PGE1 suppressed TNF-induced NF-kappaB activation and production of reactive oxygen species. We concluded that PGE1 suppressed the vascular inflammatory process, which might be closely related to the inhibition of reactive oxygen species and NF-kappaB activation in human umbilical vein endothelial cells.
  Canadian Journal of Physiology and Pharmacology 05/2010; 88(5):576-83. · 1.95 Impact Factor
• Article: WITHDRAWN: Prostaglandin E1 attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells.

  Wentong Fang, Hongjian Li, Liaosheng Zhou
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  ABSTRACT: This article has been withdrawn at the request of the author(s). The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
  Prostaglandins Leukotrienes and Essential Fatty Acids 04/2010; · 3.37 Impact Factor