Publications (3)0 Total impact
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ABSTRACT: Allogeneic marrow transplantation is a curative therapy for thalassemia, but no more than 30% of patients have HLA-indentical sibling marrow donor. The selection of alternative donors of unrelative marrow and the study on the probability of treating thalassemia major with unrelated donor bone marrow transplantation are of importance. Nine children with thalassemia were included in the study, and their gene mutational type were homozygote of thalassemia and double heterozygote, respectively. All of them were finally diagnosed of thalassemia major, and treated with unrelated donor bone marrow transplantation. To high-resolution HLA typing, two patients were matched, five had one unmatched isoform and two had two unmatched isoforms. The erythrocyte blood type was not matched in six patients. The preparative regimen included busulfan (oral use, 16 mg/kg, divided for 4 days), cyclophosphamide (intravenous use, 200 mg/kg, divided for 4 days), antithymocyte immunoglobulin (intravenous use, 30 mg/kg, divided for 3 days), and fludarabine (intravenous use, 125 mg/m(2), divided for 3 days). Ciclosporin A and methotrexate were used for graft-versus-host disease (GVHD) prophylaxis. All patients had allergen reactions. One had hypotension. Five patients experienced I degrees approximately III degrees acute GVHD in the skin, while one had II degrees acute GVHD in liver. One patient had III degrees GVHD of intestines and gradually developed chronic GVHD in the skin, lungs and brain. One patient died of pulmonary hemorrhage. The duration when peripheral blood neutrophil count exceeded 0.5 x 10(9)/L was 12 - 26 days. The recovery time of WBC was as long as 23 - 110 days. Thrombocytes exceeded 50 x 10(9) within 61 approximately 142 days. The time when hemoglobin reached 100 g/L varied from 23 to 116 days. The last blood transfusion was on 13 - 62 days. Eight patients were fully grafted, while one was not grafted. During the 6 - 24 months of follow-up, seven patients' genotype of thalassemia major became normal. The erythrocyte blood type of five patients also changed into the same as that of donor. The hemoglobin was kept over 110 g/L without blood transfusion. The transplantation of unrelated donor bone marrow for thalassemia major was successful. Unrelated donor bone marrow transplantation could cure thalassemia major, which expanded the marrow donor source for the transplantation of thalassemia major.Zhonghua er ke za zhi. Chinese journal of pediatrics 09/2005; 43(8):599-602.
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ABSTRACT: We report our experience in successful unrelated-donor bone marrow transplantation in 2 cases of beta-thalassemia major, which are approved to be the first 2 cases in Asia. The 2 children receiving transplantation of the bone marrow from unrelated donors were diagnosed as having beta-thalassemia major, whose gene mutation type was homozygous and double heterozygote. High-resolution HLA typing found a mismatch with 1 sub-locus in both cases, and red blood cell type was mismatched in 1 case. Pretransplant conditioning protocol contained busulfan (BU, 16 mg/kg x b.w.), cyclosphamide (CY, 200 mg/kg x b.w.), anti-thymocyte globulin (ATG, 90 mg/kg x b.w.) and fludarabine (25 mg x d-1 x m-2). To prevent graft-versus-host disease (GVHD) episodes, cyclosporine-A (Cs-A) and methotrexate (MTX) were administered. The 2 cases experienced condition resembling serum sickness during pretransplant conditioning. After bone marrow transplantation, 1 case had grade acute GVHD in the skin, another developed grade acute GVHD in both the skin and intestinal tract, but the condition was brought under control in both cases after proper treatment. The time for peripheral neutrophil granulocyte recovery to above 0.5 x 10(9)/L was 19 and 16 days postoperatively, respectively, and the time of WBC recovery to normal was 54 and 80 days postoperatively. Platelet recovery to over 50 x 10(9)/L occurred on postoperative days 61 and 90, and Hb recovered to above 100 g/L in both case on days 110 and 83 respectively. The time of final blood transfusion was 53 and 62 days postoperatively for the 2 patients. Gene mutation type in the 2 cases was switched to normal of the donors. After retrieval of relative literature, the 2 cases were approved as the first 2 successful unrelated-donor bone marrow transplantation cases in Asia. This will provide a new possibility of donor supply for hematopoietic stem cells transplantation in thalassemia.Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 04/2003; 23(3):281-2.
Article: 採用極性M-ary 調變跳時超寬頻系統的效能分析[show abstract] [hide abstract]
ABSTRACT: 在此論文中，我們提出兩個新種跳時超寬帶（ UWB ）系統，稱為“M-元跳 時脈衝位置調變與隨機極性超寬頻系統”，另一個系統被稱為“多脈衝跳時M- 元跳時脈衝位置調變與隨機極性超寬頻系統”。基於特徵函數分析（ CF ）的技 術，我們得出多重路徑干擾的機率分佈，平均符號間錯誤率. M-元跳時脈衝位置 調變與隨機極性超寬頻系統和多脈衝跳時M-元跳時脈衝位置調變與隨機極性超 寬頻系統的模擬和分析是在有多個使用者干擾的白色高斯雜訊通道中進行。我們 將證明，M-元跳時脈衝位置調變與隨機極性超寬頻系統和多脈衝跳時M-元跳時 脈衝位置調變與隨機極性超寬頻系統優於傳統隨機隨機超寬頻系統。 CHINESE ABSTRACT i ENGLISH ABSTRACT ii LIST OF TABLES v LIST OF FIGURES ix 1 INTRODUCTION 1 2 CONVENTIONAL TH-PPMUWBWITH POLARITY RANDOMIZATION SYSTEM 5 2.1 Signal and System Model . . . . . . . . . . . . . . . . . . . . . . . . . 5 2.2 Analysis of Conventional TH-PPM with polarity randomization System 10 2.3 Symbol Error Probability . . . . . . . . . . . . . . . . . . . . . . . . . 15 3 TIME-HOPPING M-ARY PPM UWB WITH POLARITY RANDOMIZA- TION SYSTEM 18 3.1 Signal and System Model . . . . . . . . . . . . . . . . . . . . . . . . . 18 3.2 Analysis of Time Hopping M-ary PPM UWB with Polarity Random- ization system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 3.3 Symbol Error Probability . . . . . . . . . . . . . . . . . . . . . . . . . 28 4 MULTIPLE PULSES TIME-HOPPING M-ARY PPM UWB WITH PO- LARITY RANDOMIZATION SYSTEM 31 4.1 Signal and System Model . . . . . . . . . . . . . . . . . . . . . . . . . 31 4.2 Analysis of Multiple Pulses Time-Hopping M-ary PPM UWB with Polarity Randomization System . . . . . . . . . . . . . . . . . . . . . 35 4.3 Symbol Error Probability . . . . . . . . . . . . . . . . . . . . . . . . . 39 5 SIMULATION RESULTS AND COMPARISONS 42 6 CONCLUSION 60  Moe Z. Win and Robert A Scholtz, "Impulse radio: How it works." IEEE Commun. Lett., vol. 2, no. 2, pp. 51–53, Feb. 1998.  Moe Z.Win and Robert A Scholtz, "Ultra-wide bandwidth time-hopping spread spectrum impulse radio for wireless multiple-access communications." IEEE Trans. commun., vol. 40, pp. 679-691, April. 2000.  G. Durisi and S. Benedetto, “Performance evaluation of TH-PPM UWB sys- tems in the presence of multiuser interference,”IEEE Commun. Lett., vol. 7, no. 5, pp. 224-226, May 2003.  B.Hu and N. C. Beaulieu, “Accurate evaluation of multiple access performance in TH-PPM and TH-BPSK systems,”IEEE Tran. Commun., vol., no. 10, pp. 1758-1766, Oct. 2004.  B.Hu and N. C. Beaulieu, “Accurate performance evaluation of time-hopping and direct-sequence UWB systems in multiuser interference,” IEEE Trans. commun., vlo 53., no. 6, June 2005.  S.Niranjayan, A. Nallanathan and B. Kannan, “Modeling of multiple access interference and SER derivation for M-ary TH-PAM /PPM UWB systems.” Vehicular Technology Conference, 2005. VTC 2005-Spring. 2005 IEEE 61st Volume 3, 30 May-1 June 2005 Page(s):2008 - 2012 Vol. 3  S.Niranjayan, A. Nallanathan and B. Kannan, “Modeling of multiple access interference and BER derivation for TH and DS UWB multiple access systems.” IEEE Trans. on wireles Commun., vol. 5, no. 10, October 2006, pp. 2794-2804  Zhan Yu, Tjeng Thiang Tjhung and Chin, C.C, "Performance of multiple access multicarrier MFSK system over Rician fading channels." Vehicular Technology, IEEE Transactions on Volume 54, Issue 3, May 2005 Page(s): 1091-1102  Mohammad Azizur Rahman, Shigenobu Sasaki, Jie Zhou and Hisakazu Kikuchi, "Error analysis for a hybrid DS/TH impulse radio UWB multiple access sys- tem." Ultra-Wideband, 2005. ICU 2005. 2005 IEEE International Conference on 5-8 Sept. 2005 Page(s): 5 pp.  Pasand, R.; Khalesehosseini, S; Nielsen, J.; Sesay, A; "Exact evaluation of M-ary TH-PPM UWB systems on AWGN channels for indoor multiple-access communications." Communications, IEE Proceedings, Volume 153, Issue 1, 2 Feb. 2006 Page(s):83-92.  Kyundyoung Ko; Myonghee Park; Daesik Hong; "Performance analysis of asyn- chronous MC-CDMA systems with a guard period in the form of a cyclic pre- …x." Communications, IEEE Transactions on Volume 54, Issue 2, Feb. 2006 Page(s):216-220  Qing F. Zhou and Francis C. M. Lau,"Analytical performance of M-ary TH- PPM UWB systems with multiple users."Wireless Communications and Net- working Conference,2007.WCNC 2007. IEEE 11-15 March 2007 Page(s):1625 - 1630 Digital Object Identi…er 10.1109/WCNC.2007.306  S. Gezici, H. Kobayashi, H. V. Poor and A. F. Molisch, “Performance evalua- tion of impulse radio UWB systems with pulse-based polarity randomization in asynchronous multiuser environments,”Proc. IEEE Wireless Communications and Networking Conference (WCNC 2004), vol. 2, pp. 908-913, Atlanta, GA, March 2004.