Yu-Ping Lv

Yunnan University, Yün-nan, Yunnan, China

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Publications (8)10.33 Total impact

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    ABSTRACT: Mirabilis jalapa L. is a plant belonging to the family Nyctaginaceae, which is used as a traditional folk herb in China to treat acute arthritis, inflammation, irregular menstruation, cancerous growths, and so on, and also as an anesthetic [1]. The plant extract was found to exhibit various bioactivities, including hypoglycemic, anti-plant viral, and antiviral properties, and has an inhibitory effect on experimental prostatic hyperplasia in mice [2–4]. Chemical investigations of M. jalapa have led to the isolation of isoflavones, alkaloids, terpenoids, polysaccharides, rotenoids, steroids, fatty acids, volatile compounds, peptides, and proteins [5–13]. Some of the compounds showed antifungal properties, cleave DNA, inhibit HIV-1 reverse transcriptase, are cytotoxic to Hela and Raji cell lines, and possess antimicrobial and anti-plant activities [5, 6, 12, 13]. We investigated M. jalapa to find further antitumor principles from the plant. The roots of M. jalapa were collected from Kunming, Yunnan, China in September 2003. The air-dried and chopped roots of M. jalapa (5.0 kg) were exhaustively extracted with 95% EtOH at room temperature, and the EtOH extract (200 g) was separated by column chromatography over silica gel, eluting with petroleum ether, CHCl 3 , Me 2 CO, and MeOH successively to give four fractions. The Me 2 CO fraction (50 g) was subjected to column chromatography over silica gel (200–300 mesh), eluting with CHCl 3 –MeOH (10:1–0:1) to give six subfractions. Subfraction 2 (20 g) was repeatedly subjected to column chromatography over silica gel (200–300 mesh), eluting with CHCl 3 –MeOH (10:1), and over Sephadex LH-20, eluting with MeOH–H 2 O (9:1) to yield compounds 1 (30 mg), 2 (27 mg), 3 (23 mg), 4 (33 mg), and daucosterol (15 mg). Compound 1, C 17 H 12 O 6 , yellow amorphous powder. [] D –2.44 (c 0.00285 g/100 mL, MeOH). The mass spectrum exhibited peaks for ions at m/z 312 (M + , 55), 295, 283 (100), and 267. The PMR spectrum [(CD 3 ) 2 CO, , ppm, J/Hz] displayed signals of six protons at 8.83 (1H, dd, J = 7.9, 1.5, H-1), 7.30 (1H, ddd, J = 7.9, 7.9, 1.5, H-3), 7.13 (1H, ddd, J = 7.9, 7.9, 1.5, H-2), 7.06 (1H, dd, J = 7.9, 1.5, H-4), 6.57 (1H, s, H-8), and 6.24 (1H, s, H-6), a hydroxyl [13.19 (1H, s, 11-OH)], and a methyl group [2.26 (3H, s, 10-CH 3 )]. The 13 C NMR and DEPT spectra [(CD 3 ) 2 CO, ppm] had signals at 181.2 (C-12), 163.3 (C-9), 160.6 (C-11), 157.8 (C-6a), 155.6 (C-7a), 149.9 (C-4a), 129.5 (C-3), 127.6 (C-1), 122.9 (C-2), 118.2 (C-4), 117.9 (H-1a), 109.8 (C-12a), 108.8 (C-10), 105.7 (C-11a), 93.9 (C-8), 89.4 (C-6), and 7.5 (10-Me). Based on NMR ( 1 H NMR, 13 C NMR, COSY, HMBC, HSQC, and NOESY) and mass spectral data, 1 contains a methyl, a carbonyl, and three hydroxyls. Comparison of the spectral data with those reported in the literature showed that 1 was boeravinone B [14].
    Chemistry of Natural Compounds 01/2010; 46(5):792-794. · 0.60 Impact Factor
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    ABSTRACT: Two DNA cleavage agents, meso-dihydroguaiaretic acid (1) and isobavachalcone (2) together with the known alpha-ylangene, beta-sitosterol, daucosterol, pentacosane, hexacosanic acid and cerotic acid 1-monoglyceride were isolated from the stem barks of Kadsura ananosma Kerr for the first time. Compounds 1 and 2 showed relaxation of supercoiled DNA to nicked DNA. 1 represented a new structural type of DNA cleavage agent, while 2 was reported to show DNA strand-scission activity for the first time. 1 also showed significant cytotoxic effect on Hela and Leukemia cells in vitro.
    Pharmazie 11/2006; 61(10):891-2. · 0.96 Impact Factor
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    ABSTRACT: A new iridoid tetraester, namely valeriotetrate A was isolated from the roots of Valeriana jatamansi Jones, together with the known iridoids IVHD-valtrate and valerosidate.
    Pharmazie 06/2006; 61(5):486-8. · 0.96 Impact Factor
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    ABSTRACT: Two new biflavonoids, 3"-hydroxyamentoflavone-7-O-methyl ether (1) and 3"-hydroxyamentoflavone (2), were isolated from the fruits of Aristolochia contorta Bge. Their structures were elucidated by HR-ESI-MS, 1D-, and 2D-NMR spectroscopy.
    Archives of Pharmacal Research 12/2005; 28(11):1233-5. · 1.54 Impact Factor
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    ABSTRACT: From the fruits of Aristolochia contorta Bge, beside the known aristolochic acids IVa and VII, aristolactam-N-beta-D-glucopyanoside, aristoloctam Ia N-beta-D-glucopyanoside, pinitol and daucosterol, a new biflavonoid was isolated. Its structure was determined as (+/-)-2"R,3"R-dihydro-3"-hydroxyamentoflavone (1) by means of spectral methods including 1D-, 2D-NMR and HR-ESIMS and the known compounds were identified on the basis of comparing their NMR data with those of the corresponding compounds in the literature.
    Pharmazie 11/2005; 60(10):789-91. · 0.96 Impact Factor
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    ABSTRACT: Five compounds of iridoids, lignan and phenylpropanoid glycosides were isolated from the roots of Valeriana jatamansi by column chromatography. Their structures were elucidated as 11-methoxyviburtinal (1), baldrinal (2), prinsepiol-4-omicron-beta-D-glucoside (3), coniferin (4), and hexacosanic acid (5) by spectroscopic analysis. 11-Methoxyviburtinal was a new compound, and others were isolated from the plant for the first time.
    Archives of Pharmacal Research 11/2005; 28(10):1161-3. · 1.54 Impact Factor
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    ABSTRACT: The lignans, gomisin G (1), schisantherin A (2), benzoylgomisin Q (3) and isoanwulignan (4) were isolated from the stems of Schisandra henryi. Compound 1 showed moderate DNA strand scission activity and significant cytotoxic effect on leukemia and Hela cells in vitro. Compound 1 represents a new type of DNA strand scission agent.
    Fitoterapia 07/2005; 76(3-4):370-3. · 2.23 Impact Factor
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    ABSTRACT: Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) were isolated from the stems of Schisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds 1, 2 and 4 showed moderate cytotoxic activity against Leukemia cells in vitro. Cytotoxic activity of compounds 1-4 showed IC50 of 0.0097, 0.01, 0.097 and 0.0099 micromol/mL respectively toward Leukemia cells and IC50 of 0.097, 0.1, 0.097 and 0.099 micromol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and Hela cells.
    Archives of Pharmacal Research 12/2003; 26(11):912-6. · 1.54 Impact Factor