Young-Hee Moon

Kyungpook National University, Daikyū, Daegu, South Korea

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Publications (4)6.69 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In order to elucidate the structure-antiviral activity relationship of cecropin A (1-8)-magainin 2 (1-12) (termed CA-MA) hybrid peptide, several analogues with amino acid substitutions were synthesized. In a previous study, it was shown that serine at position 16 in CA-MA hybrid peptide was very important for antimicrobial activity. Analogues were designed to increase the hydrophobic property by substituting a hydrophobic amino acid residue (S --> A, V, F or W, position 16) in the CA-MA hybrid peptide. In this study, the structure-antiviral activity relationships of CA-MA and its analogues were investigated. In particular, substitution of Ser with a hydrophobic amino acid, Val, Phe or Trp at position 16 caused a dramatic increase in the virus-cell fusion inhibitory activity. These results suggested that the hydrophobicity at position 16 in the hydrophobic region of CA-MA is important for potent antiviral activity.
    Journal of Peptide Science 05/2004; 10(5):298-303. · 2.07 Impact Factor
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    ABSTRACT: The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol-3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.
    Archives of Pharmacal Research 04/2004; 27(3):283-6. · 1.54 Impact Factor
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    ABSTRACT: Four flavonoids (1-4), a phenylethyl glycoside (5), and a phenylpropanoid glycoside (6) were isolated from the flowers of Buddleia officinalis (Loganiaceae). Their structures were determined by chemical and spectral analysis. Among the isolated compounds, luteolin (1) and acteoside (6) exhibited the most potent antioxidative activity on the NBT superoxide scavenging assay. In addition, compounds 1-6 revealed weak antifungal activity, and no hemolytic activity.
    Archives of Pharmacal Research 07/2003; 26(6):453-7. · 1.54 Impact Factor
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    ABSTRACT: A new phenolic amide, dihydro-N-caffeoyltyramine (1) was isolated from the root bark of Lycium chinense Miller, along with known compounds, trans-N-caffeoyltyramine (2), cis-N-caffeoyltyramine (3), and lyoniresinol 3alpha-O-beta-D-glucopyranoside (4). Their structures were determined by spectroscopic analysis. A NBT superoxide scavenging assay revealed that three phenolic amides showed potent antioxidative activity.
    Archives of Pharmacal Research 09/2002; 25(4):433-7. · 1.54 Impact Factor

Publication Stats

60 Citations
6.69 Total Impact Points

Institutions

  • 2004
    • Kyungpook National University
      • College of Natural Sciences
      Daikyū, Daegu, South Korea
  • 2002–2004
    • Chosun University
      • • Research Center for Proteineous Materials (RCPM)
      • • College of Pharmacy
      Goyang, Gyeonggi, South Korea