Věra Tyčová

Publications (2)3.2 Total impact

• Article: Wireless Video Capsule Enteroscopy in Preclinical Studies: Methodical Design of Its Applicability in Experimental Pigs

  Marcela Kopáčová, Ilja Tachecí, Jaroslav Květina, Jan Bureš, Martin Kuneš, Stanislav Špelda, Věra Tyčová, Zbyněk Svoboda, Stanislav Rejchrt
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  ABSTRACT: The aim of this project was to develop a methodology to introduce wireless video capsule endoscopy in preclinical research. Five mature female pigs (Sus scrofa domestica) were selected for the study. Capsule endoscopes (the EndoCapsule system; Olympus) were introduced into the duodenum endoscopically in each of the animals. The life span of batteries (i.e., total time of endoscopy recording) was 487–540min (median 492min). The capsule endoscope reached the cecum during enteroscopy once (after 7h 57min), in the remaining cases, endoscopy recordings terminated in the distal or terminal ileum. All capsule enteroscopies found a normal pattern of the small intestine. The intestinal lumen is narrower, transverse folds are sparse or even absent, villi are wider but less prominent in pigs compared to humans. Capsule endoscopy in experimental pigs will be helpful for future trials on injury of different drugs and xenobiotics to the small bowel. KeywordsCapsule endoscopy-Enteroscopy-Experimental pigs-Small bowel
  Digestive Diseases and Sciences 04/2012; 55(3):626-630. · 2.12 Impact Factor
• Article: Long-term survival of a patient after resection of a gastrointestinal stromal tumor arising from the pancreas.

  Filip Čečka, Bohumil Jon, Alexander Ferko, Zdeněk Šubrt, Dimitar H Nikolov, Věra Tyčová
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  ABSTRACT: Gastrointestinal stromal tumors (GISTs) may arise in any part of the gastrointestinal tract; extra-gastrointestinal locations are extremely rare. Only a few cases of extragastrointestinal stromal tumor arising from the pancreas were reported. None of the reports described a long-term follow-up of the patients. This report describes an interesting and unusual case of GIST arising from the pancreas. A 74-year-old female presented with a palpable abdominal mass. CT scan showed a large mass 11 x 8 x 4 cm originating from the tail of the pancreas. Percutaneous biopsy revealed a GIST predominantly with spindle cells, but some parts also contained epitheloid cells. The patient was treated by distal pancreatic resection with splenectomy. Immunohistochemistry of the tumor showed a staining pattern characteristic of GIST. The patient has achieved a long-term survival of five years and six months without any sign of recurrence of the disease. This is the first reported case of an extra-gastrointestinal stromal tumor arising from the pancreas treated surgically, with a long-term survival.
  Hepatobiliary & pancreatic diseases international: HBPD INT 06/2011; 10(3):330-2. · 1.08 Impact Factor