Publications (1)0 Total impact
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Vicente Esther,
Charnaud Sarah,
Bongard Emily, Villar Raquel,
Burguete Asunción,
Solano Beatriz,
Ancizu Saioa,
Pérez-Silanes Silvia,
Aldana Ignacio,
Vivas Livia,
Monge Antonio
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ABSTRACT: The aim of this study was to identify new compounds active againstPlasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds weresynthesized and evaluated for antimalarial activity. Eight of them showed an IC50 less than 1 μMagainst the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and goodselectivity (SI=10.35), thereby becoming a new lead-compound.
Molecules. 01/2008;
