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ABSTRACT: The aim of this study was to measure omentin-1 concentrations in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with patient-reported symptomatic severity. We enrolled 263 knee OA patients and 62 healthy controls. We collected Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from OA patients and measured omentin-1 concentrations in serum and SF by enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that omentin-1 concentrations in SF but not serum were independently and negatively correlated with self-reported greater pain and physical disability in OA patients. Omentin-1 in SF might serve as a potential biomarker for reflecting the symptomatic severity of OA.
Scandinavian journal of clinical and laboratory investigation 10/2012; · 1.38 Impact Factor
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ABSTRACT: To evaluate the outcome of cancellous bone grafting plus iliac cancellous bone in the treatment of non-traumatic avascular talar necrosis.
Twenty patients, 14 males and six females, eight at stage II, ten at stage III and three at stage IV according to the modified Ficat & Arlet necrosis classification system, were treated with vascularized bone flap from January 2000 to June 2005.
All patients were followed up for a mean of 37 months (range: 14 to 68 months). The clinical function outcome evaluated by Kenwright criteria were excellent in 8 cases, good in 10 cases, fair in 1 case and poor in 1 case. Clinical symptom was completely or partially relieved. The necrotic area was filled with newly formed bone and the excellent-to-good rate was 90%.
Transposition of vascularized cuneiform bone flap plus iliac cancellous bone grafting may be an ideal therapeutic method for non-traumatic avascular talar necrosis. And the clinical outcome is satisfactory.
Zhonghua yi xue za zhi 04/2010; 90(15):1035-8.
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ABSTRACT: To evaluate the effect of digital subtraction angiography (DSA) in evaluation of the hemodynamic changes after treatment of avascular osteonecrosis of femoral head with vascularized bone flaps.
Fifty-four patients, 33 males and 21 females, 33 hips being at the stage II and 21 hips being at the stage III, were treated with vascularized bone flaps, including iliac bone flaps pedicled with ascending branch of lateral femoral circumflex artery for 23 hips, greater trochanter bone flaps pedicled with gluteal muscle branch of ascending branch of lateral femoral circumflex artery for 13 hips, greater trochanter bone flaps pedicled with transverse branch of ascending branch of lateral femoral circumflex artery for 9 hips, and greater trochanter bone flaps pedicled with gluteal muscle branch and transverse branch of ascending branch of lateral femoral circumflex artery for 9 hips. Selective DSA was performed on all 54 patients pre-operatively and on 19 patients 6-24 months post-operatively.
DSA before operation demonstrated abnormal vascularization in all 54 patients. Six months after operation reconstruction of blood supply on the femoral head was seen in 48 cases. Six patients showed poor filling or failure of filling of the vessel pedicles in transplanted bone flaps 6 months post-operatively and DSA conducted 8 months postoperatively showed satisfactory filling in one of the 6 cases. The clinical success rate of this group was 91%, and the radiological success rate was 85%.
Selective DSA is effective in evaluation of the postoperative hemodynamic changes in the necrotic femoral head. Significant blood supply in the bone flap is the key point in the success of treatment of ONFH.
Zhonghua yi xue za zhi 03/2006; 86(7):438-41.
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ABSTRACT: To research on the conservative methods used to preserve the femoral head of patients with osteonecrosis of the femoral head.
In these series surgical procedures the osteonecrotic lesion was removed and various vascularized bone blocks or periosteal flaps with its nutrient vessels were transferred to regain sphericity of the femoral head and reinforce the sequestrum. The current study assessed 1005 patients (1226 hips) operated on from 1989 to 2002 with an average follow-up of 5.1 years (range, 1.5-15 years). The mean age of the patients was 37.4 years (range, 17-65 years).
Sixty-one hips (57 patients) had conversion surgery to a total hip arthroplasty because of progressive collapse or severe pain, or both. In the patients without failure, postoperative Harris hip score improved significantly. Of the 1174 reconstructions that were in situ, 1041 (89.4%) were clinically successful, and 878 (75.4%) were radiologically successful. In relation to the stage of necrosis according to the classification system of Ficat and Alert, good results were achieved in 95.3% of the patients with stages II disease, 87.9% with stages III and 60.8% with stages IV.
Conservative methods of vascularized bone block or periosteal flap transfer should be considered in active symptomatic patients to preserve the femoral head. In addition, the earlier the stages of the disease the better outcome could be obtained.
Zhonghua wai ke za zhi [Chinese journal of surgery] 09/2005; 43(16):1054-7.
