Talal A. K. Al-Allaf

Applied Science Private University, `Ammān, Amman, Jordan

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Publications (34)58.51 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Several palladium(II) and platinum(II) complexes analogous to oxaliplatin, bearing the enantiomerically pure (1R,2R)-(−)-1,2-diaminocyclohexane (DACH) ligand, of the general formula {MX2[(1R,2R)-DACH]}, where M = Pd or Pt, X (COO)2, CH2(COO)2, , , {1,1′-C5H8(CH2COO)2}, [1,1′-C6H10(CH2COO)2], [1,1′-(COO)2ferrocene], , , , MeCOO and Me3CCOO, were synthesized. All the complexes prepared were characterized physicochemically and spectroscopically. Some selected complexes were screened in vitro against several tumor cell lines and the results were compared with reference standard drug, oxaliplatin. Copyright © 2009 John Wiley & Sons, Ltd.
    Applied Organometallic Chemistry 05/2009; 23(5):173-178. · 2.02 Impact Factor
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    ABSTRACT: Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary diphosphines Ph2P(CH2) n PPh2, (n = 1–4) and benz-1,3-imidazoline-2-thione, benz-1,3-oxazoline-2-thione or benz-1,3-thiazoline-2-thione have been prepared and characterized by elemental analysis, magnetic susceptibility, molar conductance and i.r. spectral data. 31P–{1H}-n.m.r. data have been applied to characterize the produced linkage isomers.
    Transition Metal Chemistry 03/2007; 32(3):281-286. · 1.40 Impact Factor
  • Subhi A. Al-Jibori, Ali I. Abdullah, Talal A. K. Al-Allaf
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    ABSTRACT: Palladium(II) and platinum(II) complexes containing mixed ligands N-(2-pyridyl)acetamide (AH) or N-(2-pyrimidyl)acetamide (BH) and the diphosphines Ph2P(CH2) n PPh2, (n = 1, 2 or 3) have been prepared. The prepared complexes [Pd(A)2(diphos)] or [Pd(B)2(diphos)] have been used effectively to prepare bimetallic complexes of the type [(diphos)Pd(μ-L)2M′Cl2] where M′ = Co, Cu, Mn, Ni, Pd, Pt or SnCl2; L = A or B. The prepared complexes were characterized by elemental analysis magnetic susceptibility, i.r. and UV–Vis spectral data. 31P–{1H}-n.m.r. data have been applied to characterize the produced linkage isomers.
    Transition Metal Chemistry 03/2007; 32(3):398-406. · 1.40 Impact Factor
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    ABSTRACT: The complexes [ML2A2] or [ML2B] where M=Pd or Pt, L=5-phenyl-1,3,4-oxadiazole-2-thione ion, A=tertiary monophosphines and B=tertiary diphosphines have been used effectively to prepare bimetallic complexes of the type [A2M(μ-L)2M′Cl2] or [BM(μ-L)2M′Cl2], where M′=Co, Pd or SnCl2. The prepared complexes were characterized by elemental analysis, magnetic susceptibility, IR and UV–Vis spectral data. 31P–{1H} NMR data have been applied to characterize the produced linkage isomers.
    Polyhedron 07/2004; 23(11):2013–2020. · 2.05 Impact Factor
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    ABSTRACT: Several Schiff bases derived from salicylaldehyde and aminopyridines were found to coordinate with Me2SnCl2 in 1:1 or 1:2 (tin:base) molar ratio in diethylether, depending on the nature of the Schiff base used, to form complexes of the general formula Me2SnCl2·L or Me2SnCl2·2L respectively. These Schiff bases coordinate with Ph2SnCl2 in a similar manner, but if the reaction is carried out in chloroform or if the product formed in ether is dissolved in chloroform then colourless to pale yellow crystals precipitated. The latter were analysed and found to be due to the ionic compounds [H2NpyN–H+]2 [Ph2SnCl4]2− which were formed as a result of an unusual cleavage of the CN bond of the Schiff bases. The Schiff bases, their Me2SnCl2 complexes and the ionic compounds were analyzed physicochemically and spectroscopically. The crystal structures of two of the ionic compounds showed that the cation [H2NpyN–H+] binds with the anion [Ph2SnCl4]2− via hydrogen bonds. The Schiff bases, their Me2SnCl2 complexes and the ionic compounds were screened against the three tumour cell lines, L929, K562 and HeLa, and the results were compared with those of the anticancer drugs, cisplatin, carboplatin and oxaliplatin. Copyright © 2003 John Wiley & Sons, Ltd.
    Applied Organometallic Chemistry 11/2003; 17(12):891 - 897. · 2.02 Impact Factor
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    ABSTRACT: Treatment of the complexes [MCl2(DPPF)] (M=Pt or Pd) {readily prepared in high yield from [MCl2(DMSO)2] (M=Pt (cis-) or Pd (trans-) and DPPF in CHCl3} with two molar proportions of AgNO3 in H2O did not give the expected cation [M(DPPF)(H2O)2]2+ in solution. Instead the unusual homobimetallic bridged complex [{M(μ-OH)(DPPF)}2](NO3)2 was formed as an insoluble solvolysis solid product. Hence, carboxylation by addition of carboxylate anions to the solution cannot be carried out by this method. In contrast, the complex [PtCl2(DPPF)] reacted readily with two molar proportions of AgOAc or one of Ag2{1,1′-(OOC)2fc} (fc=ferrocene-2H) in acetone to give the corresponding carboxylato complexes. Other carboxylato complexes were obtained from the reaction of the complexes [MCl2(DPPF)] and the K-salts of e.g. (COOH)2, CH2(COOH)2, and in H2O. With few exceptions, neither the K- nor the Ag-salts of the acids Me3CCOOH and C6H11COOH react completely with [MCl2(DPPF)] in aqueous or non-aqueous solutions. However, the required products were obtained by displacement of DMSO from the corresponding carboxylato complexes by DPPF in CHCl3. All of the new carboxylato complexes and the solvolysis products were characterized physicochemically and spectroscopically. The X-ray structures of [Pt{(OOC)2}(DPPF)] and of [PtCl(NO3)(DPPF)] were determined, to obtain some additional information on the coordination mode of the unsymmetrical DPPF ligand in this type of complexes.
    Journal of Organometallic Chemistry 07/2003; 678(s 1–2):48–55. · 2.30 Impact Factor
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    ABSTRACT: The nucleophilic substitution reaction of the enantiomerically pure ligand, (1R,2R)-(−)-1,2-diaminocyclohexane [DACH] (1) with cis-bis(benzonitrile)palladium(II) dichloride [(PhCN)2PdCl2] leads to the formation of the complex [(DACH)PdCl2] (2) in a high yield. The reaction of the corresponding platinum(II) complex [(PhCN)2PtCl2] with DACH, under the same reaction conditions, surprisingly, took a different course, in which nucleophilic addition to the benzonitrile ligand occurred forming an enantiomerically pure amidine complex [(PhCNHNH(C6H10)NH2)Pt(NCPh)Cl]Cl (3), where the nitrogen ligand form a seven-membered chelate around the central atom. The aqua and oxalato derivatives of complex 2, [(DACH)Pd(H2O)2](NO3)2 (4) and [(DACH)Pd(C2O4)] (5) have also been prepared and characterized. The platinum analogue complex to 5, [(DACH)Pt(C2O4)] (6), was prepared starting from the enantiomerically pure isomer (1) and the platinum salt K2PtX4 (X=Cl, I). According to X-ray structural analysis carried out on the complex, the product does not consist of just the desired isomer, but a mixture of both the trans-l (trans-(−)-1R,2R) and trans-d (trans-(+)-1S,2S) isomers. No retention of optical isomerism was observed. The single crystal structural analysis was also carried out on the ligand N,N′-(1R,2R)-(−)-diaminocyclohexane dihydrochloride (DACH·2HCl)] (1a). The result indicates, however, that only the R,R-isomer exists in the free ligand.
    Polyhedron 06/2003; 22(12):1529-1534. · 2.05 Impact Factor
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    ABSTRACT: Several new PtII and PdII complexes bearing the enantiomerically pure (1R,2R)-(-)-l,2-cyclohexanediamine (dach) ligand, of general formula [MX2{(1R,2R)-dach}], where M = Pt or Pd, X2 = cis- or trans- or (1R,2R)-1,2-cyclohexyldicarboxylate anions, have been synthesized and characterized physicochemically and spectroscopically. These complexes have been screened in vitro against the three tumour cell lines K562, HeLa and L929, and the results obtained were compared with those of the reference standards, cisplatin, carboplatin and oxaliplatin; the known antitumour drugs. The single crystal X-ray structure determination of the [Pt(C2O4)(cis-dach)] complex has been discussed and compared with that of oxaliplatin, [Pt(C2O4){(1R,2R)-dach}].
    Transition Metal Chemistry 01/2003; 28(6):717-721. · 1.40 Impact Factor
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    Talal A.K. Al-Allaf
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    ABSTRACT: The stannylenes R2Sn, (R = N(SiMe3)2 or CH(SiMe3)2) insert into M-X bonds of complexes [MX2L2] to give new complexes of the general formula [MX(SnR2X)L2], (M = Pt, Pd, Ni; X = Cl, N3, NO2; L = PEt3, PBu3, DPPE). They also insert into Pt-Cl bonds of the bridged complexes [{Pt(μ-Cl)Cl(L)}2], to give the new bridged complexes[ &lcub Pt(μ-Cl)(SnR2Cl)(L)}2], (R = N(SiMe3)2, L = PEt3, PBu3, PMe2Ph, PPh3), in which the bridge remained uncleaved. In one reaction of the stannylene R2Sn, where R = CH(SiMe3)2, the bridged complex [{Pt(μ-Cl)(SnR2Cl)(PEt3)}2] undergoes cleavage followed by migration of Cl to give [PtCl(SnR2Cl)( η2-SnR2)(PEt3)]. Further, the bridged complex [{Pt(μ-Cl)(SnR2Cl)(PEt3)}2], (R = N(SiMe3)2), with the neutral ligands L`, (L` = PPh3, pyridine or AsPh3), undergoes bridge cleavage to form the complexes [PtCl(SnR2Cl)(PEt3)(L`)]. The reaction of the stannylene R2Sn, (R = N(SiMe3)2) with the platinum(0) complexes [Pt(C2H4)(PPh3)2] and [Pt(COD)2], COD = 1,5-cyclooctadiene is described. The complexes obtained have been characterised mainly by 31P NMR spectroscopy and elemental analysis.
    Journal of Chemical Research 12/2002; 2003(2):101-104. · 0.70 Impact Factor
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    ABSTRACT: The palladium(II) complex trans-bis[(R)-(+)-bornylamino]palladium(II) dichloride was synthesised and characterised. The solid state structure of the complex was determined by X-ray structure analysis. The compound crystallises in the monoclinic space group P2(1) with a=12.383(2), b=23.689(5), c=12.769(3) A, beta=93.25(3) degrees, and V=3739.6(13) A(3). The complex was tested for its cytotoxicity against L(929), K(562) and HeLa cell lines using the MTT assay technique. It is also tested for its anticomplementary activity using a test that detects complement proteins inhibition. These activities were compared with those of the reference standards, cisplatin, carboplatin and oxaliplatin. The significance of these results is given and discussed.
    European Journal of Medicinal Chemistry 12/2002; 37(11):919-22. · 3.43 Impact Factor
  • Talal A. K Al-Allaf
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    ABSTRACT: The R2Sn moieties formed when the cyclic compounds (R2Sn)n, R=Me or Ph, n=6; R=Et, n=9, are exposed to light, react with the platinum(II) complexes [PtCl2L2], L=PEt3, PPr3, PBu3, PEtPh2, PPh3 to give new complexes of the general formula [PtCl(SnR2Cl)L2]. Similarly, Et2Sn from (Et2Sn)9 reacts with [PtMe(Cl)L2] to give [PtMe(SnEt2Cl)L2] and Ph2Sn from (Ph2Sn)6 reacts with [PtPh(Cl)L2] or [PtPh2L2] to give [PtPh(SnPh2Cl)L2] or [PtPh(SnPh3)L2] (L=PEt3), respectively. Reactions involving (R2Sn)n and the bridged complex [{Pt(μ-Cl)ClL}2] give a mixture of [PtCl(SnR2Cl)L2] and [PtCl(SnRCl2)L2], R=Me or Et, L=PBu3. It is suggested that these reactions initially involve insertion of R2Sn moieties into PtCl bonds of the complexes [PtX(Cl) L2] or [{Pt(μ-Cl)ClL}2] then generate R2SnXCl (X=Cl, Me, Ph) and the Pt(0)complex [PtL2], which undergoes oxidative-addition of the formed tin(IV) species to give complexes containing PtSn bonds. With (Ph2Sn)6 and [PtPh2L2], the mechanism takes a different course. Reactions under similar conditions involving the Pt(0) complexes [Pt(C2H4)(PPh3)2] or [Pt(COD)2], (COD=1,5-cyclooctadiene) and (R2Sn)6, R=Me or Ph, gave no detectable complexes containing PtSn bonds. The complex [Pt(PEt3)4] and (MeSn)6 likewise gives no species containing PtSn bonds but with (Ph2Sn)6, two complexes, tentatively identified as trans-[PtPh(Sn2Ph5)(PEt3)2] and trans-[PtPh(Sn6Ph11)(PEt3)2], were detected in the solution. In all cases, the products were identified by 31P-NMR spectroscopy.
    Journal of Organometallic Chemistry 01/2002; 654(1):21-28. · 2.30 Impact Factor
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    ABSTRACT: The mixed phosphine–phosphine oxide Ph2PCH2CH2P(O)Ph2 (dppeO) reacts with either trans-[PdCl2(PhCN)2], Na2[PdCl4] or trans-[PdCl2(DMSO)2] to give trans-[PdCl2{1-Ph2PCH2CH2P(O)Ph2}2]. Treatment of the latter with the metal chlorides, MCl2 nH2O (M = Mn, Cu, Co, Zn, Hg; n = 4, 2, 6, 1, 0, respectively) or with Me2SnCl2 or SnCl4 5H2O, or with UO2(NO3)2 6H2O or UO2(OAc)2 2H2O gives heterobimetallic complexes: trans-[PdCl2{-Ph2PCH2CH2P(O)Ph2}2MX2] nH2O. The cobalt complex (MX2 = CoCl2) was unstable in solution (MeOH or EtOH/CHCl3), and reverts to trans-[PdCl2{1-Ph2PCH2CH2P(O)Ph2}2] and CoCl2. trans-[PdCl2{1-Ph2PCH2CH2P(O)Ph2}2] does not apparently react with either NiCl2 6H2O or CdCl2 2.5H2O.
    Transition Metal Chemistry 01/2001; 26(1):186-188. · 1.40 Impact Factor
  • T A al-Allaf, L J Rashan
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    ABSTRACT: A large body of novel platinum and palladium complexes, in both the cis- and trans-forms, with various donor ligands, e.g. beta-carboline alkaloids, pyrazoles, DMSO, ferrocenylphosphines,...... have been tested for their antitumour activity against number of fluid suspension (P388, L1210, K562, and Raji) and solid tumour (KB, T47D, SW948, HeLa, A549, L929, Hep-2, RD,...) cell lines. Remarkable cytotoxic effects against these cell lines were observed by some of these complexes. The preliminary results indicated that most of the trans-palladium complexes showed a better activity than the cis-platinum isomers and superior activity than that of the cis-palladium isomers. More importantly they showed activities equal to (or superior than) those of cisplatin, carboplatin and oxaliplatin (the anti-cancer drugs) in vitro. Although these results are preliminary, however, encouraging since they are in a disagreement with the previous studies that cis-isomers are more active than trans-ones; the complexes which have not received the required attention from the vast number of researchers in this field.
    Bollettino chimico farmaceutico 01/2001; 140(3):205-10.
  • Talal A.K. Al-Allaf
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    ABSTRACT: Organotin(IV) compounds SnRxCl4−x (R=Me, Ph; x=4−0) add oxidatively to [Pt(COD)2] (COD=cycloocta-1,5-diene) to yield platinum(II) complexes in which Pt has inserted into the SnCl or SnR bonds, displacing one COD entity. The new complexes react with tertiary phosphines, e.g. PEt3, PPh3, Ph2PCH2CH2PPh2 (DPPE) at or below room temperature with displacement of the remaining COD. Some of the resulting platinum–phosphine complexes, e.g. cis-[PtMe(SnMe3)(PPh3)2], cis- or trans-[PtCl(SnMe3)(PPh3)2] cannot be prepared by the direct reaction between [Pt(C2H4)(PPh3)2] or [Pt(PPh3)3] and SnMe4 or SnMe3CI, respectively, showing the advantage of this method. Both the COD complexes and their corresponding phosphine complexes were characterised by physical and spectroscopic methods. The thermodynamic stabilities of the complex [PtCl(SnMe3)(COD)], its corresponding phosphine complex, cis- and trans-[PtCl(SnMe3)(PPh3)2], and the complex cis-[PtMe(SnMe3)(PPh3)2] were studied.
    Journal of Organometallic Chemistry 11/1999; 590(1):25–35. · 2.30 Impact Factor
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    ABSTRACT: Several dimethyltin dichloride complexes of the general formula Me2SnCl2.L, where L = 8-hydroxy quinoline (L1), 8-hydroxy quinoline-N-oxide (L2),2,6-diaminopyridine (L3), 3-amino aniline (L4), cyclohexyl amine (L5), (1R, 2R)-1,2-cyclohexane diamine (L6), 3,5-dimethylpyrazole (L7), harmaline (L8) and harmine (L9), have been prepared and characterized physicochemically and spectroscopically. It was found that tin coordinated with the active site of these ligands to give complexes with penta-coordinated tin or, to some extent, hexa-coordinated tin. The cytotoxic activities of these complexes have been studied against Hep-2, HeLa, L20B and RD lines using the MTT-colorimetric assay. These activities were compared with those of the three reference standards, cisplatin, carboplatin and oxaliplatin. Some of these complexes exhibited a range of significant activities against the cell lines used, whereas no cytotoxic activities were exhibited by the rest of these complexes. The significance of these results is given and discussed.
    Bollettino chimico farmaceutico 07/1999; 138(6):267-71.
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    Talal A. K. Al-Allaf, Luay J. Rashan
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    ABSTRACT: Four platinum(II) complexes of the general formula cis-[Pt{(Ferr)2PhP}(DMSO)X2], where X2 = Cl2, C2O4, O2(CO)2(C6H11)2 and O2(CO)2CCH2CH2CH2, have been synthesized and­characterized physicochemically and spec-­troscopically as the first heterobimetallic platinum(II) complexes with the ligand diferrocenylphenylphosphine (Ferr = ferrocenyl). These complexes were tested in vitro against leukaemia cell line P388 using the MTT assay. The results obtained were compared with those of cisplatin, carboplatin, oxaliplatin and 5-fluorouracil. Copyright © 1999 John Wiley & Sons, Ltd.
    Applied Organometallic Chemistry 01/1999; 13(1):63-68. · 2.02 Impact Factor
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    ABSTRACT: Treatment of cis-[Pt(dmso)2Cl2] with 2 mol of KBr or KI leads to the formation of the analogous dibromide or diiodide complexes. Treatment of [M(dmso)2Cl2] [M = Pt (cis-) or Pd (trans-)] with AgNO3 (2 mol) in H2O followed by 1mol of potassium oxalate, maleate, cyclobutane dicarboxylate (CBDC), malonate or 2mol of potassium cyclohexane carboxylate or pivalate leads to the formation of the corresponding PtII and PdII carboxylate complexes. The single crystal X-ray structure determination of [Pt(dmso)2(CBDC)] has been discussed and compared with data on other related complexes. The in vitro cytotoxic activity of some of these complexes against eight tumour cell lines has been examined using the MTT-colorimetric assay.
    Transition Metal Chemistry 07/1998; 23(4):403-406. · 1.40 Impact Factor
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    ABSTRACT: Six dimethyltin(IV) carboxylate compounds of the general formula Me2SnX2, where X = 1/2 O2(CO)2 (oxalate), 1/2 O2(CO)2CH2 (malonate), 1/2 O2(CO)2CH = CH (maleate), 1/2 O2(CO)2C-CH2CH2CH2 (cyclobutyl dicarboxylate), O(CO)C6H11 (cyclohexane carboxylate) and O(CO)CMe3 (pivolate) have been prepared and characterized physicochemically and spectroscopically. The cytotoxic activities of these carboxylates have been studied against HeLa, Hep-2, RD, L20B and P388 cell lines using the MTT-colorimetric assay. These activities were compared with the cytotoxic activities of the three reference standards, cisplatin, carboplatin and oxaliplatin. The compounds were X = 1/2 malonate, 1/2 maleate, cyclohexane carboxylate and pivolate exhibited a range of significant activities against the cell lines used, whereas no cytotoxic activities were exhibited by the rest of the six compounds. The significance of these results is given and discussed.
    Bollettino chimico farmaceutico 03/1998; 137(2):55-8.
  • Talal A.K. Al-Allaf, Luay J. Rashan
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    ABSTRACT: Treatment of trans-[Pd(DMSO)2Cl2] with naturally occurring alkaloid harmine, in a 1:1 molar ratio in DMSO, leads to the formation of trans-[Pd(DMSO)(harmine)Cl2]. The latter was isolated from DMSO solution by addition of 0.05 M HCl solution. The complex has been characterized physicochemically and spectroscopically. It was tested for its cytotoxicity against P388, L1210 and K562 cell lines, and showed promising activity, as a first trans-palladium(II) complex, when compared with the reference standards cisplatin, carboplatin and 5-fluororuracil (5-FU).
    European Journal of Medicinal Chemistry 01/1998; 33(10):817-820. · 3.43 Impact Factor
  • Talal A. K. Al-Allaf, Manal A Al-Sham'a, Luay J Rashan
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    ABSTRACT: Diorganotin dichloride compounds, Rl2SnCl2 (R=Me, nBu, Ph) react with Schiff bases (L), derived from substituted and non-substituted 2- or 3-aminopyridine with 2-hydroxy-, 2-methoxy- or 2-hydroxy-3-methoxy-benzaldehyde in a 1 : 1 molar ratio, to give complexes of general formula R2SnCl2·L. It is suggested that the Schiff bases coordinate with tin in bidentate fashion to give hexacoordinate tin species. Almost all the complexes prepared show some 1 : 1 molar conductivity in ethanol and DMF, indicating on R2Sn(L)Cl+ Cl− ionic structure type. The complexes were screened against seven species of bacteria.
    Applied Organometallic Chemistry 09/1996; 10(7):545-548. · 2.02 Impact Factor

Publication Stats

124 Citations
58.51 Total Impact Points

Institutions

  • 2007–2009
    • Applied Science Private University
      `Ammān, Amman, Jordan
  • 2002–2004
    • Jordan University of Science and Technology
      • Department of Chemistry
      Arbēla, Irbid, Jordan
  • 1998–2003
    • Amman Arab University
      `Ammān, Amman, Jordan
  • 2001–2002
    • University of Jordan
      • Faculty of Science
      `Ammān, Amman, Jordan
  • 1988–1999
    • University of Mosul
      • • Department of Chemistry (Science)
      • • College of Education
      • • College of Sciences
      Mosul, Muhafazat Ninawa, Iraq
  • 1994
    • University of Tikrit
      • College of Science
      Tikrīt, Muhafazat Salah ad Din, Iraq