T Thorlacius

Publications (2)7.21 Total impact

• Article: A whole genome association study in Finnish multiple sclerosis patients with 3669 markers.

  M Laaksonen, A Jonasdottir, R Fossdal, J Ruutiainen, S Sawcer, A Compston, K Benediktsson, T Thorlacius, J Gulcher, J Ilonen
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  ABSTRACT: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex genetic background. In the present study, based in the Finnish population, we typed a large number of microsatellite markers in separately pooled DNA samples from 195 MS patients and 205 controls. A total of 108 markers showed evidence of association. Five genomic regions containing two or more of these markers within a 1-Mb interval were identified, 1q43, 2p16, 4p15, 4q34 and 6p21 (the MHC region). Substantial overlap with previously published linkage genome screens is also seen.
  Journal of Neuroimmunology 11/2003; 143(1-2):70-3. · 2.96 Impact Factor
• Article: Genome-wide linkage screen of a consanguineous multiple sclerosis kinship.

  H Modin, T Masterman, T Thorlacius, M Stefánsson, A Jónasdóttir, K Stefánsson, J Hillert, J Gulcher
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  ABSTRACT: Multiple sclerosis (MS), like Alzheimer's disease (AD) and Parkinson's disease (PD), is a common neurological disorder thought to be caused by the interaction of several genes with unknown environmental factors. In both AD and PD the identification of disease forms inherited in a classic Mendelian fashion has helped investigators elucidate pathogenetic mechanisms. In this study a whole-genome screen, with an average of 608 successful genotypes per person, was performed on nine members of a consanguineous family: the index case, three of her siblings and her daughter, all of whom have been diagnosed with definite MS; as well as the parents of the index case (first cousins), one of her five healthy siblings and her husband (who is also her first cousin). Nonparametric linkage analysis was performed on genotyping data. Based on the presence of consanguinity, the a priori hypothesis was that the disease is transmitted in an autosomal recessive fashion in the pedigree. Linkage analysis revealed a suggestive logarithm of odds (LOD) score of 2.29 on the long arm of chromosome 9. Four of five affected family members were identically homozygous for a haplotype under this peak, spanning approximately 43 cM, while the fifth affected subject and all unaffected family members were heterozygous for the haplotype.
  Multiple Sclerosis 04/2003; 9(2):128-34. · 4.26 Impact Factor