Sophie Binet

Publications (2)5.11 Total impact

• Article: Discovery of new C3aR ligands. Part 2: amino-piperidine derivatives.

  Frédéric Denonne, Sophie Binet, Maggi Burton, Philippe Collart, Sabine Defays, Alan Dipesa, Maria Eckert, Alexander Giannaras, Seema Kumar, Beth Levine, Jean-Marie Nicolas, Patrick Pasau, Cécile Pégurier, Dorin Preda, Nathalie Van houtvin, Andrew Volosov, Dong Zou
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  ABSTRACT: The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.
  Bioorganic & Medicinal Chemistry Letters 07/2007; 17(12):3262-5. · 2.55 Impact Factor
• Article: Discovery of new C3aR ligands. Part 1: arginine derivatives.

  Frédéric Denonne, Sophie Binet, Maggi Burton, Philippe Collart, Alan Dipesa, Tanmoy Ganguly, Alexander Giannaras, Seema Kumar, Timothy Lewis, Florence Maounis, Jean-Marie Nicolas, Tamsin Mansley, Patrick Pasau, Dorin Preda, Karin Stebbins, Alexander Volosov, Dong Zou
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  ABSTRACT: The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported. DMPK properties and functional activities of selected compounds have been evaluated. One compound is shown to be active in an in vivo model of airway inflammation after aerosol administration.
  Bioorganic & Medicinal Chemistry Letters 07/2007; 17(12):3258-61. · 2.55 Impact Factor