Sergio Negrin Dastis

Publications (4)12.58 Total impact

• Article: Ulcerative colitis associated with IgG4 cholangitis: similar features in two HLA identical siblings.

  Sergio Negrin Dastis, Dominique Latinne, Christine Sempoux, André P Geubel
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  ABSTRACT: IgG4-associated cholangitis (IAC) can mimic primary sclerosing cholangitis although, in contrast to the latter, it is highly responsive to steroid therapy. IAC is known to be associated with autoimmune pancreatitis and has also been shown to be part of a more complex autoimmune IgG4 syndrome. However, an association with inflammatory bowel disease (IBD), a condition in which its identification may have therapeutic and prognostic importance, has not yet been described. We report the cases of two HLA identical siblings both DRB *1501 positive exhibiting features of IAC together with ulcerative colitis. Subsequent high resolution HLA typing performed by sequence-based-typing showed similar alleles in both siblings: A *0301 A *3201 B *07 (0702/62) B *1401 C *0702 C *0802 DRB1 *1501. There is indirect evidence that this hitherto undescribed association, likely to be strongly linked to a genetic background, might account for a proportion of the cases of cholangitis associated with IBD. Appropriate investigation for IBD-associated cholangitis is mandatory to identify IAC, the recognition of which has particular therapeutic and prognostic implications.
  Journal of Hepatology 08/2009; 51(3):601-5. · 9.26 Impact Factor
• Article: Liver transplantation for nonsteroidal anti-inflammatory drug-induced liver failure: nimesulide as the first implicated compound.

  Sergio Negrin Dastis, Jacques Rahier, Jan Lerut, André P Geubel
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  ABSTRACT: Among industrialized countries, the rate of drug-induced liver failure varies widely accounting for about 1-12% of the indications for liver transplantation. Nonsteroidal anti-inflammatory drugs (NSAIDs) are with antibiotics the most frequently involved compounds. In this single-center series of 57 consecutive cases of acute liver failure treated by orthotopic liver transplantation, five were related to NSAIDs-induced liver damage, three being due to nimesulide use. This has to be taken as a further warning about the potential for this compound to induce liver failure.
  European Journal of Gastroenterology & Hepatology 12/2007; 19(11):919-22. · 1.76 Impact Factor
• Article: [Minimally invasive treatment of obesity with the intragastric balloon: a review].

  Sergio Negrin Dastis, Thai Nguyen-Tang, Jean-Marc Dumonceau
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  ABSTRACT: Obesity is currently one of the most important problems in public health because of its prevalence and potential complications. The National Institute of Health (NIH) recommends to decrease body weight by about 10% because this initial weight loss can significantly decrease the severity of obesity-associated risk factors. The intragastric balloon (IB) was developed as a temporary aid to obtain such a weight loss and to induce a modification of eating habits. Results are encouraging in terms of weight loss, and improvement of co-morbidity. The best results have been obtained in patients with a body mass index (weight/size2) comprised between 30 and 40 kg/m 2, but superobese patients may also be good candidates for IB therapy before bariatric surgery. Overall complications are estimated to develop in about 3% of cases.
  Revue médicale suisse 10/2007; 3(123):1958, 1960-1.
• Article: Complete disappearance of lung abnormalities on high-resolution computed tomography: a case of histiocytosis X.

  Sergio Negrin-Dastis, Dominique Butenda, Jacques Dorzee, Jacques Fastrez, Jean-Paul d'Odémont
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  ABSTRACT: A case of pulmonary Langerhans cell histiocytosis, proved by both lung high-resolution computed tomography and lung biopsy, is described. Following smoking cessation, lung nodules and cysts gradually disappeared on serial computed tomography scans, with complete clearance of the lesions after 12 months. The role of tobacco smoking is discussed, in detail, against the background of the literature.
  Canadian respiratory journal: journal of the Canadian Thoracic Society 14(4):235-7. · 1.56 Impact Factor