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Publications (5)7.26 Total impact

  • S. Culine, N. Mottet, S. Rousmans
    Oncologie. 01/2008; 10(11):681-685.
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    ABSTRACT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French Cancer Centres (FNCLCC), the 20 French regional cancer centres, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. To update the SOR recommendations for the use of radiation therapy in the management of patients with osteosarcoma. This work was performed in collaboration with the French society against cancers in children and adolescent (SFCE). Data have been identified by literature search using Medline (from January 1992 to October 2003). In addition several Internet sites were searched in October 2003. The 3 mains standards are: 1) local and exclusive curative irradiation is not indicated as primary treatment for osteosarcoma or for local and operable recurrence, except for lesion in inaccessible sites or if the patient refuses surgery; 2) local and prophylactic adjuvant irradiation is not indicated for the treatment of osteosarcoma after chemotherapy (neoadjuvant and/or adjuvant) and complete macro or microscopic surgery, except for non-operable R1 or R2 surgical resection; 3) whole-lung prophylactic irradiation is not indicated in non-metastatic osteosarcoma. Systemic metabolic radiotherapy for pain treatment, using samarium-153 ethylenediaminetetramethylene phosphonic acid (Sm-153-EDTMP) can be offered to patients with painful metastatic osteosarcoma or in case of recurrent bone sites inaccessible to local therapies (surgery, external irradiation).
    Cancer/Radiothérapie 04/2005; 9(2):104-21. · 1.48 Impact Factor
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    ABSTRACT: The "Standards, Options and Recommendations" (SOR) project, which started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French Regional Cancer Centers, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. To define clinical practice guidelines for the management of adult patients with intracranial glioma in collaboration with the Association of French-speaking Neuro-oncologists (Anocef) and the French society of neurosurgeons (SNCLF). These recommendations cover diagnosis, classification, treatment and follow-up of patients with these tumors. The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts who define the CPGs according to the definitions of the Standards, Options and Recommendations project. Once the guidelines has been defined, the document is submitted for review by independent reviewers. This article is a summary version of the full document presenting the clinical practice guidelines with algorithms. The main recommendations concern the place of the surgery, radiotherapy, chemiotherapy, imagery and concomitant medical treatments in the specific treatment strategy of grade III and IV glioma, grade II glioma, gliomatosis cerebri, pilocytic astrocytoma, subependymoma, xanthoastrocytoma, intracranial ependymoma and brain stem glioma.
    Bulletin du cancer 11/2003; 90(10):873-86. · 0.61 Impact Factor
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    ABSTRACT: *Both DF and OC contributed equally to this paper (DF on behalf the Neuro-oncology Group of the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) and OC on behalf of the Association of French-speaki ng Neuro-oncologists (Association des Neuro-Oncologues d'Expression Française - ANOCEF))
    British Journal of Cancer 09/2003; 89 Suppl 1:S73-83. · 5.08 Impact Factor
  • S. Culine, N. Mottet, S. Rousmans
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    ABSTRACT: ContexteLe programme « Standards, Options: Recommandations » (SOR) a été initié par la Fédération nationale des centres de lutte contre le cancer et est actuellement piloté par l’Institut national du cancer. Dans ce contexte, les SOR ont réalisé, en collaboration avec l’Association française d’urologie (AFU), une synthèse méthodique des données de la littérature portant sur la prise en charge thérapeutique du patient atteint d’une tumeur germinale non séminomateuse (TGNS) ou séminomateuse (TGS) du testicule traité par radiothérapie (RT), chimiothérapie (CT) ou surveillance (SV) après orchidectomie totale. MéthodeUne recherche bibliographique systématique a été effectuée par interrogation de la base de données Medline® (de janvier 2004 à août 2007) et la consultation de sites Internet d’Evidence Based Medicine. Les essais randomisés, les revues systématiques, les études d’observation portant sur le patient atteint d’une TGNS ou TGS de stade localiséou avancé ont éte inclus. L’éligibilitéet la qualité des essais retrouvés ont été évaluées par trois opérateurs indépendants. ConclusionVingt-neuf références ont été incluses. Pour les TGNS de stade localisé, le choix d’une stratégie de prise en charge thérapeutique adaptée au risque de rechute semble approprié: SV pour le patient à faible risque et CT dans les autres cas. Pour les stades avancés, la suppression de la bléomycine pose encore des questions. Pour les TGS de stade localisé, le choix de la SV ou la CT par rapport à la RT doit être confirmé par des essais randomisés avec un suivi suffisamment long étant donné les résultats encourageants obtenus en termes de tolérance avec la carboplatine ou encore une diminution de dose d’irradiation (20 Gy au lieu de 30 Gy). Enfin, pour les stades avancés, l’utilisation d’une monochimiothérapie à base de carboplatine n’a pas fait la preuve de son intérêt par rapport à la polychimiothérapie à base de cisplatine. BackgroundThe “Standards, Options and Recommendations” (SOR) programme in oncology, has been initiated in 1993 by the Federation of French Cancer Centres; today, it is placed under the authority of the French National cancer institute. In this context, a collaborative work of systematic review, of the management of non-seminomatous (NSTGC) or seminomatous (STGC) testicular germ cell cancer treated with primary radiotherapy (RT), chemotherapy (CT) or surveillance (SV) after radical orchidectomy is proposed by the SOR programmeand the French Association of Urology. MethodA systematic literature search has been performed on Medline® between 01/2004 and 08/2007 and completed by a survey of Evidence-Based Medicine websites. Randomised controlled trial, systematic reviews, and observational studies carried out in patients with locally or advanced tumour have been included. Studies have been assessed for eligibility and quality by three independents reviewers. ConclusionTwenty-nine trials were identified as eligible for this analysis. The choice of risk-adapted treatment for patients with locally NSTGC seems to be appropriate: SV for low-risk patients and CT for others. For advanced stage tumours, the suppression of bleomycine remains questionable. For local STGC, the choice of SV or CT versus RT needs to be confirmed by RCT with prolonged follow-up given the promising results regarding the treatment toxicity obtained with carboplatine or lower irradiation dose (20 Gy instead of 30 Gy). For advanced STGC, the usefulness of a carboplatine single agent treatment versus cisplatin-based combination chemotherapy has not been proved.
    Oncologie 10(11):681-685. · 0.10 Impact Factor