Ronaldo Rodrigues de Freitas

Santa Casa de São Paulo, San Paulo, São Paulo, Brazil

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Publications (9)20.61 Total impact

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    ABSTRACT: Lichen planus is a common disorder of the stratified squamous epithelium that affects oral and genital mucous membranes, skin, nails, and scalp. Oral Lichen Planus (OLP) affects middle-aged women and shows distribution patterns and characteristics such as white striations, white plaques or papules, erythema, blisters and erosions, and may be associated with medication and/or dental materials used by the patient. The clinical diagnosis can only be made if the disease presents classical patterns such as concomitant lesions in the oral mucosa and skin. The laboratory diagnosis is histopathologically characterized by the presence of projections of the epithelium in the form of sawtooth and Civatte bodies and allows the exclusion of dysplasia and malignancy. Direct immunofluorescence is used when there is suspicion of other diseases, such as pemphigus and pemphigoid. OLP is treated with anti-inflammatory agents, particularly topical corticosteroids; new agents and techniques have proved effective. The malignant transformation of OLP and its exact incidence remain controversial. This work aims at presenting, through literature review, the etiopathogenesis, clinical diagnosis, laboratory tests, and complications of OLP.
    Anais brasileiros de dermatologia 10/2010; 85(5):669-75.
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    Perionews. 05/2010; 4(3):268-270.
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    ABSTRACT: Resumo Introdução: A mucosite é a complicação bucal mais comum e dose limitante do tratamento antineoplásico, causada pelos efeitos da radioterapia e quimioterapia, principalmente no TMO. Nenhum tratamento proposto até hoje foi totalmente efetivo, pois a mucosite é de difícil prevenção e controle. Novas modalidades de tratamento vêm sendo colocadas à disposição, sendo uma delas o uso terapêutico do LASER de baixa potência, podendo ser usado profilaticamente, tendo poucas desvantagens. Objetivo: Avaliar o efeito do LASER terapêutico na prevenção da mucosite oral em pacientes submetidos a Transplante de Medula Óssea. Métodos: Foram avaliados 16 pacientes em um grupo de estudo (sob laserprofilaxia) e 23 pacientes em um grupo controle (sem laserprofilaxia) submetidos a transplante de medula óssea, avaliando os graus de mucosite pela escala da Organização Mundial de Saúde (OMS). Resultados: Foram observa-das redução na gravidade, e leve redução da incidência da mucosite oral dos pacientes submetidos à laserterapia (GE) em relação ao grupo controle (GC). Conclusão: O uso do LASER é uma terapêutica auxiliar importante na prevenção da mucosite oral em pacientes submetidos a TMO, mas acreditamos que outros estudos prospectivos devam ser realizados para demonstrar sua efetividade. Descritores: Mucosite/prevenção & controle, Mucosite/
    Arquivos Médicos dos Hospitais e Faculdade de Ciências Médicas da Santa Casa de São Paulo. 03/2010; 55(1):7+11.
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    ABSTRACT: Malignant osteopetrosis (MO) is a rare hereditary disease that affects young children. Its physiopathology is explained by a basic defect in osteoclast precursor cells, with a radiographic image of diffuse sclerosis and increased bone density. The bone contains an increased number of structurally abnormal osteoclasts. Infections commonly occur because the neutrophils exhibit reduced chemotactic response and decreased ability of bacterial phagocytosis. A white female patient aged 9 months, of mixed descent, was diagnosed at birth as having MO after bone marrow biopsy. Dental examination revealed the presence of four teeth, all of which had enamel hypoplasia and no carious lesions. After bone marrow transplantation (BMT), an erythematous lesion appeared on the alveolar ridge on day 2, with signs of tooth exfoliation. On day 7, there was gingival bleeding, edema, and erythema at the region of the maxillary incisors with grade 3 mobility, without changes in food intake. Concerning the oral cavity, the patient maintained grade 1 tooth mobility without tooth exfoliation or other oral alterations. Accurate diagnosis and careful therapeutic planning are important to avoid the secondary complications of the disease.
    The Cleft Palate-Craniofacial Journal 08/2009; 46(4):388-90. · 1.24 Impact Factor
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    Journal of Clinical Oncology 02/2009; 27(9):1522-3. · 18.04 Impact Factor
  • Revista Brasileira de Hematologia e Hemoterapia 01/2009; 31(6).
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    ABSTRACT: B-cell lymphomas account for around 90% of all cases of lymphoma. The appearance of oral lesions with this type of lymphoma is uncommon but in cases where involvement is seen, the anterior region of lower jaw is most frequently affected. Here the case of a 22-year-old male patient is reported; he was diagnosed with large B cell lymphoma in the mediastinal pleura and after 1 year of treatment he evolved with a nodular lesion in the anterior region of the lower jaw involving the incisors. Histological diagnosis and immunohistochemistry confirmed secondary lymphoma. The patient was submitt Rev. Bras. Hematol. Hemoter.
    Revista Brasileira de Hematologia e Hemoterapia 12/2008; 31(6):473-476.
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    Flavio Alves Andrade, Paulo Sérgio da Silva Santos, Ronaldo Rodrigues de Freitas
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    ABSTRACT: Individuals diagnosed with Acute Myeloid Leukemia (AML) may submit oral manifestations resulting from the disease itself, as well as demonstrations consequential to the treatment of chemotherapy and radiotherapy. In this case report describes a patient of 08 years-old diagnosed with AML (M5), which made the following oral manifestations: bleeding, grade 4 oral mucositis (WHO), gingival overgrowth compatible with leukemic gingival infiltration, petechiae and ecchymosis in lips and necrotic lesion in the ower left permanent first molar. We conclude that the presence of the dentist in onco-haematological team may decrease the morbidity related to oral complications that are likely to affect these patients, and increase the comfort and quality of life of this patients.
    Arq Med Hosp Fac Cienc Med Santa Casa São Paulo. 05/2008; 53(2-53(2)):85 - 87.
  • Journal of Oral and Maxillofacial Surgery 09/2006; 64(8):1292-5. · 1.33 Impact Factor