Robert Mathvink

Publications (2)5.11 Total impact

• Article: Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

  Jinyou Xu, Lan Wei, Robert Mathvink, Scott D Edmondson, Anthony Mastracchio, George J Eiermann, Huaibing He, Joseph F Leone, Barbara Leiting, Kathryn A Lyons, Frank Marsilio, Reshma A Patel, Aleksandr Petrov, Joseph K Wu, Nancy A Thornberry, Ann E Weber
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  ABSTRACT: anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.
  Bioorganic & Medicinal Chemistry Letters 04/2006; 16(5):1346-9. · 2.55 Impact Factor
• Article: Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

  Jinyou Xu, Lan Wei, Robert Mathvink, Jiafang He, You-Jung Park, Huaibing He, Barbara Leiting, Kathryn A Lyons, Frank Marsilio, Reshma A Patel, Joseph K Wu, Nancy A Thornberry, Ann E Weber
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  ABSTRACT: anti-Substituted beta-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. These are among the most potent compounds reported to date lacking an electrophilic trap. The most potent compound among these is 5-oxo-1,2,4-oxadiazole 44, which is a 3 nM DPP-IV inhibitor.
  Bioorganic & Medicinal Chemistry Letters 06/2005; 15(10):2533-6. · 2.55 Impact Factor