R. Caliz

Publications (4)9.1 Total impact

• Article: [Formation of specialists in rheumatology: Accreditation criteria]

  A. Olive, J. Angel Jover, R. Caliz, F. Diaz, M. Garcia-Castro, N. Guanyabens, S. Talaverano, J. de Toro, E. Trujillo, J. Uson, J. L. Andreu
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  ABSTRACT: The National Rheumatology Board is responsible for postgraduate formation in rheumatology. Herein we present the new criteria for accreditation of teaching units. These criterion contemplate four domains, namely: structure, clinical work, teaching and research. Each domain is divided in subdomains and items. Some of them are of an obligatory nature. This document serves as reference for future applications. The document may be reviewed in the future.
  Reumatol Clin. 01/2010; 6(6):311-5.
• Article: HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients.

  R Caliz, T Atsumi, E Kondeatis, O Amengual, M A Khamashta, R W Vaughan, J S Lanchbury, G R Hughes
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  ABSTRACT: We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS). HLA DRB1, DQB1 and DQA1 genotypes were determined by the polymerase chain reaction using sequence-specific primers in 83 Caucasoid British patients with APS. The genotype frequencies were compared between subgroups of patients and 177 healthy controls. DQB1*0604/5/6/7/9-DQA1*0102-DRB1*1302 and DQB1*0303-DQA1*0201-DRB1*0701 haplotypes showed significantly positive correlations with APS [P=0.0087 and P=0.0012, respectively]. The association of the former was enhanced in primary APS patients with anti-beta 2-glycoprotein I antibodies (anti-beta 2GPI) [odds ratio 6.2, 95% confidence interval (2.2-17.6), P=0.0014, corrected P=0.042]. These alleles and haplotypes might affect anti-ss2GPI production and APS development in different and heterogeneous fashion.
  Rheumatology 02/2001; 40(1):31-6. · 4.06 Impact Factor
• Article: Fcgamma receptor IIA H/R131 polymorphism in patients with antiphospholipid antibodies.

  T Atsumi, R Caliz, O Amengual, M A Khamashta, G R Hughes
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  ABSTRACT: A role for Fcgamma receptor in the pathophysiology of thrombosis in APS has been hypothesized. The polymorphism of this receptor, FcgammaRIIA H/R131, is associated with the binding affinity for human IgG2 (i.e. FcgammaRIIA-H131 isoform has a higher affinity than FcgammaRIIA-R131). Since anti-beta2 glycoprotein I antibodies (anti beta2GPI), which play a major pathogenic role in APS, show IgG2 dominant distribution, we investigated the prevalence of receptor isoforms in patients with antiphospholipid antibodies (aPL) by a PCR-RFLP method. We studied 100 Caucasian patients with aPL (57 primary APS, 32 secondary APS to SLE and 11 other diseases with aPL) and 41 healthy controls. H131/H131, H131/R131 and R131/R131 genotypes were found in 21 (21%), 50 (50%) and 29 (29%) in the patient group, and 9 (22%), 23 (56%) and 9 (22%) in control group, respectively. Thus there was no statistically significant difference in the prevalence of each genotype in these groups. None of the clinical manifestations of primary APS (arterial/venous thrombosis, recurrent pregnancy loss and thrombocytopenia) was significantly correlated with any FcgammaRIIA genotype. In conclusion, FcgammaRIIA polymorphism did not correlate with the manifestations of APS, and FcgammaRIIA genotype is not a genetic marker of APS.
  Thrombosis and Haemostasis 06/1998; 79(5):924-7. · 5.04 Impact Factor
• Article: Genetic determinants of rheumatoid arthritis: the inducible nitirc oxide synthase (NOS2) gene promoter polymorphism

  M Pascual, M.A. Lopez-Nevot, R. Caliz, B.P.C. Koeleman, A Balsa, D Pascual-Salcedo, J Martin