Quan-feng Luo

Publications of Quan-feng Luo

• Treatment guidelines of lymphatic malformations of the head and neck.

  Authors: Qin Zhou, Jia Wei Zheng, Hua Ming Mai, Quan Feng Luo, Xin Dong Fan, Li Xin Su, Yan An Wang, Zhong Ping Qin

  Oral oncology. 09/2011; 47(12):1105-9.

  Lymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few casesLymphatic malformations, traditionally called lymphangiomas, are diseases caused by development errors of the lymphatic system. About 90% of the cases occur within 2years of age, except a few cases which occur in adulthood, and approximately 75% of the lesions are located in the head and neck region. The lesions can grow rapidly with infection, trauma or bleeding, resulting in disfigurement as well as severe impairment of respiration, swallow and speech. Although lymphatic malformations are benign lesions, they rarely resolve spontaneously, their infiltrating nature coupled with the difficulty in distinguishing involved vital structures of head and neck from adjacent normal tissues makes complete surgical resection even more difficult. The likelihood of postsurgical recurrence and complications is thus higher than other vascular lesions. Surgical resection, sclerotherapy and laser therapy are currently the main treatment modes of lymphatic malformations. Various treatment options have their advantages and disadvantages, the selection of treatment modalities should depend on the patient's individual status and available technology and expertise. The treatment protocol should be individualized, comprehensive as well as sequential in order to obtain the best treatment outcome. Based on published literatures and clinical experiences, we devised the treatment guideline for management of head and neck lymphatic malformations. This protocol will be reviewed and updated periodically to include cutting edge knowledge to provide the best treatment options to benefit our patients.

• The effects of Bleomycin A5 on infantile maxillofacial haemangioma.

  Authors: Quan-feng Luo, Fu-yun Zhao

  Head & face medicine. 01/2011; 7:11.

  To examine the effects of bleomycin A5 on infantile maxillofacial haemangiomas. Bleomycin A5 was given by multiple intralesinoal injections and the dosage was given according to the age of theTo examine the effects of bleomycin A5 on infantile maxillofacial haemangiomas. Bleomycin A5 was given by multiple intralesinoal injections and the dosage was given according to the age of the patient and size of the lesion. Parts of patients were accompanied by prednisone treatment (2-5 mg/kg, po, QOD. All the haemangiomas involutes completely after treated with bloemycin A5 with better recovery of skin color and less scar forming in small haemangiomas. Infantile haemangioma could be effectively treated with bleomycin A5 without serious side effects.

• [The therapeutic effect of triamcinolone acetonide with Pingyangmycin on lymphatic malformations in oral and maxillofacial regions].

  Authors: Wei Zhang, Quan-Feng Luo, Ling Zhang, Tong-Xuan Zhang, Xiang-Li He

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 07/2010; 26(4):262-5.

  To investigate the therapeutic effect of Triamcinolone Acetonide and Pingyangmycin on lymphatic malformations in oral and maxillofacial regions. 29 patients with lymphatic malformations in oral andTo investigate the therapeutic effect of Triamcinolone Acetonide and Pingyangmycin on lymphatic malformations in oral and maxillofacial regions. 29 patients with lymphatic malformations in oral and maxillofacial regions were divided into two groups to receive intra-lesion injection with Triamcinolone Acetonide and Pingyangmycin in experimental group, or with Pingyangmycin only in control group. The lesions involution and facial appearance were observed. 2 years after treatment, the volume of small cyst and micro-cyst type mass shrank to (3.7 +/- 0.3)% and (4.2 +/- 0.4)%, respectively in experimental group, while (15.4 +/- 1.3)% and (24.1 +/- 3.1)% in control group. The lesion involution was markedly obvious in experimental group. Compare with control group, the facial asymmetry was greatly improved in experimental group. Intra-lesion injection with Triamcinolone Acetonide and Pingyangmycin is an effective method for the treatment of lymphatic malformations in oral maxillofacial regions. The mass can be shrank markedly to improve facial symmetry.

• [Dignosis and therapy on hemangiomas and vascular malformation in view of the new classification.]

  Authors: Fu Yun Zhao, Yan Gao, Mei Juan Wu, Quan Feng Luo, Yu Liu, Zhen Qi Xu

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 03/2009; 41(1):21-7.

  Vascular birthmarks are the most common disease. The morbidity is about 2.5%, most of the lesions occur in oral and maxillofacial regions which accounts for 40%-60% of the total lesions. In 1982,Vascular birthmarks are the most common disease. The morbidity is about 2.5%, most of the lesions occur in oral and maxillofacial regions which accounts for 40%-60% of the total lesions. In 1982, Mulliken and Glowacki proposed a biologic classification of vascular birthmarks on the basis of their clinical manifestations, histopathological features, and natural history. They defined hemangiomas as vascular tumors with a growth phase, marked by endothelial proliferation and hypercellularity, and an involutional phase. They recognized that many entities referred to as hemangiomas are actually structural alformations of the vasculature, derived from capillaries, veins, lymph vessels, or arteries or from a combination of these sources. The classification was confirmed and issued by International Society for the study of vascular anomality (ISSVA) in 1988. Waner and Suen amended the above category in 1995. This paper presents the new classification of vascular birthmarks and the developments in this field in recent years, including the pathology, clinical features and the therapy. For example, the classification of venular malformation categorized by Waner in 1989; the classification of lymphous malformation by Waner and Suen in 1995; and the treatments according to above classifications.

• [The preoperative design for remodeling inferior one-third facial contour]

  Authors: Quan-feng Luo, Xing Wang

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 10/2007; 23(5):381-4.

  OBJECTIVE: Facial contour remodeling is an important part of plastic surgery. Some skeletal abnormalities, such as mandible protrude, maxillary retrusion, induce the facial asymmetry (includingOBJECTIVE: Facial contour remodeling is an important part of plastic surgery. Some skeletal abnormalities, such as mandible protrude, maxillary retrusion, induce the facial asymmetry (including arrowy direction or/and coronary direction), malocclusion, etc. These abnormalities are seen commonly in the lower one third of the face. Evaluation and preoperative design is very important for the treatment of these abnormalities. The purpose of this item is to summarize our experience in the preoperative design during the treatment. METHODS AND RESULTS: Observation of the facial feature of the patient, cephalometric tracing, face-bow transfer and model reconstruction were necessary for the preoperative design. Three-dimensional direction was included in the bone movement for operation and soft tissue should be taken into account simultaneously. All the factors mentioned above were summarized, and outcomes were gathered. CONCLUSIONS: Determination of facial midline was very important, especially for asymmetry patient. The bone was moved in three-dimensional direction. The same site of osteotectomy may produce different effects by different movements.

• [The changes of the muscular fiber phynotype at different condition of nerve injury]

  Authors: Quan-feng Luo, Zuo-liang Qi, Wei Wang, Xing Wang

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 02/2006; 22(1):12-5.

  OBJECTIVE: To observe the change of the muscular fiber phynotype at different condition of nerve injury. METHODS: Rabbits were used as an animal model in this study. The trigeminus and facial nervesOBJECTIVE: To observe the change of the muscular fiber phynotype at different condition of nerve injury. METHODS: Rabbits were used as an animal model in this study. The trigeminus and facial nerves of the animal were simultaneously severed (group 1) or only the latter was severed (group 2). The morphologic change of the muscular fibers was observed with histochemical methods; the tension of contraction and the threshold value of electrical stimulation were observed with electrical physiological methods. RESULTS: Trigeminus nerve play an important role in delaying muscular atrophy after facial nerve was severed. The atrophy degree of type II a and II b muscular fibers was less in group 2 than that in group 1. The change of type 1 muscular fibers was not affected by trigeminus nerve. New muscular fibers emerged in group 2. The tension of contraction and the threshold value of electrical stimulation were better in group 2 than that of in group 1. CONCLUSIONS: Sensory nerve could delay muscle atrophy after denervation. Sensory nerve should be repaired simultaneously when the motor nerve was sutured. The results of this study would facilitate clinical treatment for facial palsy.

• [The transformation of fibroblast-like cells originating from different tissue into osteoblasts]

  Authors: Quan-feng Luo, Xing Wang, Biao Yi, Zi-li Li, Xiao-Xia Wang, Cheng Liang

  Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. 08/2005; 40(4):327-30.

  OBJECTIVE: To discuss whether fibroblast-like cells can transform into osteoblasts under specific condition during distraction osteogenesis. METHODS: Fibroblast-like cells were cultured in vitro.OBJECTIVE: To discuss whether fibroblast-like cells can transform into osteoblasts under specific condition during distraction osteogenesis. METHODS: Fibroblast-like cells were cultured in vitro. BMP-2, TGF-beta(1), BMP-2 and TGF-beta(1) were added into the medium, and the cellular change were observed by histochemistry and immunohistochemistry methods. The distraction was given on the membrane of fibroblast-like cells, and the cellular change were observed under the distraction. RESULTS: fibroblast-like cells from the joint could transform into osteoblasts under the effect of BMP-2 or BMP-2 with TGF-beta(1). Fibroblast-like cells from other regions could not transform into osteoblasts. CONCLUSION: The osteoblasts during distraction osteogenesis are multi-origin.

• [The effect of platelet-rich plasma on the distraction osteogenesis]

  Authors: Quan-feng Luo, Xing Wang, Xiao-Xia Wang, Biao Yin, Zi-li Li, Cheng Liang

  Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 10/2004; 20(5):376-9.

  OBJECTIVE: To observe the effect of the platelet-rich plasma (PRP) on osteogenesis during bone distraction. METHODS: The osteoblasts were cultured in vitro. The rabbits were used as the animal modelOBJECTIVE: To observe the effect of the platelet-rich plasma (PRP) on osteogenesis during bone distraction. METHODS: The osteoblasts were cultured in vitro. The rabbits were used as the animal model of distraction osteogenesis. The proliferation of osteoblasts was analysed through MTT methods. The osteogenesis was observed by histochemical and histoimmunochemical methods. RESULTS: PRP stimulated the proliferation of osteoblasts and facilitated distraction osteogenesis. CONCLUSIONS: PRP could accelerate the osteogenesis during bone distraction. The application of PRP in clinical practice might shorten the period of distraction osteogenesis.

• [The effects of PL-derived growth factor on osteogenesis and skeletal reconstruction]

  Authors: Quan-feng Luo, Xing Wang

  Shanghai kou qiang yi xue = Shanghai journal of stomatology. 07/2004; 13(3):207-10.

  Platelet-derived growth factor (PDGF) plays an important role in osteogenesis and skeletal reconstruction. PDGF participates in the process of osteogenesis and bone absorption simultaneously. ItPlatelet-derived growth factor (PDGF) plays an important role in osteogenesis and skeletal reconstruction. PDGF participates in the process of osteogenesis and bone absorption simultaneously. It stimulates the marrow stromal mesenchymal cell to proliferate and differentiate, accelerates the calcium aggradation into extracellular matrix, and stimulates chondrocytes proliferation and differentiation. Furthermore, PDGF can act on osteoclasts directly or indirectly to promote bone absorption. The dual-effects of PDGF facilitate osteogenesis and skeletal reconstruction.

• [Effect of trigeminus nerve on facialis-denervated facial muscle atrophy]

  Authors: Quan-Feng Luo, Xiu-E Li, Zu-Xun Gong

  Sheng li xue bao : [Acta physiologica Sinica]. 05/2002; 54(2):94-8.

  In the present study we made out an animal model on rabbit whose trigeminus and facialis nerves were simultaneously or only the latter one was severed. The pathological changes in facial muscleIn the present study we made out an animal model on rabbit whose trigeminus and facialis nerves were simultaneously or only the latter one was severed. The pathological changes in facial muscle atrophy under different nerve injuries were investigated. The degeneration of contractile proteins of upper lip muscle -- myosin and actin was observed. In addition, we also examined the ultrastructural changes in the muscle atrophy in the two above-mentioned nerve injury cases. We observed that the intact trigeminus nerve could delay and lighten the atrophy of facialis-denervated facial muscle and attenuate the degeneration of myosin and actin, as well as decrease the increment of collagen and maintain the ultrastructure of the thick and thin muscle filaments. These results may provide the possibility of improvement of clinical treatment for facial muscle palsy.