Nicole E Gross

Publications (14)33.35 Total impact

• Chapter: Ophthalmic Fundus Imaging

  Michael D. Ober, Lawrence A. Yannuzzi, Jason S. Slakter, Richard F. Spaide, Yale L. Fisher, Robert W. Flower, Richard Rosen, Christina M. Klais, Nicole E. Gross
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  ABSTRACT: The medical-retina specialty finds its origins in the classic 1967 study, “The Pathogenesis of Disciform Detachment of the Neuro-epithelium” by Dr. J. Donald Gass, which was published initially as a supplemental issue of the American Journal of Ophthalmology. Prior to this milestone in the field, specialists in “retina” were essentially “bucklers,” that is, individuals trained to excel in indirect ophthalmoscopy in order to find “breaks” and to reattach the retina.
  12/2008: pages 389-406;
• Article: Fundus Autofluorescence in Retinopathy Caused By Deferoxamine Toxicity

  Shantan Reddy, Diana Iturralde, Catherine Meyerle, Nicole E. Gross, Lawrence A. Yannuzzi
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  ABSTRACT: Purpose: To describe the fundus autofluorescence photographic pattern in a case of deferoxamine retinopathy. Methods: Observational case report. Results: A 91-year-old woman receiving intravenous deferoxamine treatment presented with a history of deteriorating vision in both eyes. Autofluorescence photography revealed well circumscribed areas of hyperautofluorescence that correlated with areas of pigmentation shown by color photography. Deferoxamine retinopathy was diagnosed. Conclusion: Fundus autofluorescence photography is a noninvasive imaging method for early detection of deferoxamine retinopathy and can be used to monitor the status of the macula in patients at risk for this toxicity.
  Retinal Cases & Brief Reports 12/2006; 1(3):120-122.
• Article: Multiple evanescent white dot syndrome.

  Nicole E Gross, Lawrence A Yannuzzi, K Bailey Freund, Richard F Spaide, Gian Paolo Amato, Ruth Sigal
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  ABSTRACT: To study the clinical and angiographic features of lesions in a case series of multiple evanescent white dot syndrome (MEWDS), to describe a newly recognized clinical variation of the disorder, and to gain insight into its pathophysiological nature. Five patients with MEWDS (selected based on angiographic manifestations of the disorder) were examined using slitlamp biomicroscopy and studied using fluorescein angiography and indocyanine green angiography. All 5 patients exhibited the newly recognized angiographic features termed dots and spots, which varied in size and location in the fundus. Small dots were in the inner retina or at the level of the retinal pigment epithelium, and larger spots were more external in the subpigment epithelial area. All patients exhibited other characteristics typical of MEWDS, including field loss and foveal granularity. In this case series of MEWDS, a clinical variant consisting of dual-layered lesions with specific features on clinical examination, fluorescein angiography, and indocyanine green angiography was identified. On late indocyanine green angiography, these lesions produced highly specific findings of small hypofluorescent lesions overlying larger hypofluorescent lesions. Based on the angiographic findings, it seems as if MEWDS is a chorioretinopathy with varying degrees of retinal and choroidal involvement.
  Archives of Ophthalmology 05/2006; 124(4):493-500. · 3.71 Impact Factor
• Article: Nature and risk of neovascularization in the fellow eye of patients with unilateral retinal angiomatous proliferation.

  Nicole E Gross, Alexander Aizman, Allison Brucker, James M Klancnik, Lawrence A Yannuzzi
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  ABSTRACT: To determine the nature and risk of neovascularization in the fellow eyes of patients with unilateral retinal angiomatous proliferation (RAP), a neovascular form of age-related macular degeneration (AMD). A consecutive series of 52 patients diagnosed with unilateral RAP were studied retrospectively. Clinical biomicroscopic examination, fluorescein angiography, and indocyanine green angiography were used to evaluate all patients for the development of neovascular manifestations in the fellow eye. Neovascularization developed in the fellow eye in 52 patients over the follow-up period (range, 2-36 months). All patients developed neovascular manifestations of RAP in the fellow eye. Twenty-one patients (40%) developed a RAP lesion within 1 year; 29 (56%), within 2 years; and 52 (100%), within 3 years. At the time of diagnosis of neovascularization in the fellow eye, 8 patients (15%) had a stage I RAP lesion, 36 (70%) had a stage II RAP lesion, and 8 (15%) had a stage III RAP lesion. Other characteristic findings in these patients included the presence of preretinal, intraretinal, and subretinal hemorrhages in 49 patients (94%) and pigment epithelial detachments in 41 patients (79%). In patients diagnosed with unilateral RAP lesions, the form of neovascularization that develops in the fellow eye is virtually always RAP. The annual and accumulative risk of neovascularization in the fellow eye is higher in patients with RAP than in those with other forms of neovascular AMD. These new findings enhance our understanding of the clinical spectrum of RAP in terms of its natural course and visual prognosis and may possibly offer useful information to establish future treatment options.
  Retina 10/2005; 25(6):713-8. · 2.81 Impact Factor
• Article: Choroidal infarction following photodynamic therapy with verteporfin.

  Christina M Klais, Michael D Ober, K Bailey Freund, Leonard H Ginsburg, Alan Luckie, Martine Mauget-Faÿsse, Gabriel Coscas, Nicole E Gross, Lawrence A Yannuzzi
  Archives of Ophthalmology 09/2005; 123(8):1149-53. · 3.71 Impact Factor
• Article: Retinal choroidal collateral circulation after radial optic neurotomy correlated with the lessening of macular edema.

  Richard F Spaide, James M Klancnik, Nicole E Gross
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  ABSTRACT: To evaluate patients who had undergone radial optic neurotomy for central retinal vein occlusion for the presence of retinal choroidal collateral circulation and to correlate these collaterals with changes in macular thickness during follow-up. Radial optic neurotomy is designed to release proposed pressure within the scleral canal. Retrospective review of patients undergoing radial optic neurotomy. The patients had a baseline examination including ophthalmoscopy, fluorescein angiography, and optical coherence tomography. At an interval follow-up at approximately 3 months the patients were reevaluated with ophthalmoscopy, optical coherence tomography, and indocyanine green angiography. There were 6 patients, and the mean age was 68.3 years. The mean time from onset of the central retinal vein occlusion to the radial optic neurotomy was 2.3 months. One patient had no collateral vessels, three patients had significant collaterals, and two patients had moderate-caliber collaterals. The mean central macular thickness preoperatively was 1,021 microm and the mean central macular thickness postoperatively was 733 microm. The change in macular thickness was highly correlated with the degree of development of collaterals from the retinal to the choroidal circulation (P = 0.008, Spearman's rho = 0.93). Although all patients had a radial optic neurotomy a significant determinant in reduction of macular edema was the presence of retinal-choroidal collateral circulation. This suggests that there may be additional mechanisms, other than simple release of alleged pressure in the scleral canal, for any observed effects from radial optic neurotomy.
  Retina 07/2004; 24(3):356-9. · 2.81 Impact Factor
• Article: Optical coherence tomography findings in photic maculopathy.

  Sheau Jiun Huang, Nicole E Gross, Danielle L L Costa, Lawrence A Yannuzzi
  Retina 01/2004; 23(6):863-6. · 2.81 Impact Factor
• Article: Inexpensive illuminated vitrectomy cutter.

  Yale L Fisher, Nicole E Gross, Carl Wang
  Retina 01/2004; 23(6):891. · 2.81 Impact Factor
• Article: Retinal-choroidal indocyanine green dye clearance and liver dysfunction.

  Danielle L L Costa, Sheau J Huang, Dennis A Orlock, K Bailey Freund, Lawrence A Yannuzzi, Richard F Spaide, Nicole E Gross
  Retina 09/2003; 23(4):557-61. · 2.81 Impact Factor
• Article: Retinal-Choroidal Indocyanine Green Dye Clearance and Liver Dysfunction

  DANIELLE L.L. COSTA, SHEAU J. HUANG, DENNIS A. ORLOCK, K. BAILEY FREUND, LAWRENCE A. YANNUZZI, RICHARD F. SPAIDE, NICOLE E. GROSS
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  ABSTRACT: An abstract is unavailable. This article is available as HTML full text and PDF.
  Retina 07/2003; 23(4):557-561. · 2.81 Impact Factor
• Article: Peripheral drusen in membranoproliferative glomerulonephritis type II.

  Sheau Jiun Huang, Danielle L L Costa, Nicole E Gross, Lawrence A Yannuzzi
  Retina 07/2003; 23(3):429-31. · 2.81 Impact Factor
• Article: Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study.

  Lawrence A Yannuzzi, Jason S Slakter, Nicole E Gross, Richard F Spaide, Danielle L L Costa, Sheau J Huang, James M Klancnik, Alexander Aizman
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  ABSTRACT: Most patients with central serous chorioretinopathy (CSC) have spontaneous resolution of exudative macular detachments and a good visual prognosis. Patients with CSC have a primary choroidal hyperpermeability problem evident as multifocal areas of hyperpermeability during indocyanine green (ICG) angiography. A small percentage of patients develop chronic or progressive disease with widespread decompensation of the retinal pigment epithelium and severe vision loss. There is no known treatment for this variant of the disorder. To study ICG-guided photodynamic therapy (PDT) with verteporfin as a potential treatment for patients with chronic CSC. Twenty eyes of 15 patients were studied with fluorescein angiography, optical coherence tomography, and ICG angiography to diagnose the maculopathy, monitor the detachments, and localize the choroidal hyperpermeability of the disorder. PDT with ICG guidance was applied to areas of choroidal hyperpermeability, and the patients were observed to determine the anatomic and functional outcomes. Photodynamic therapy guided by ICG was associated with complete resolution of exudative macular detachments in 12 patients and incomplete resolution in the remaining eight eyes. The vision improved in six eyes and remained unchanged in 14 eyes during a mean follow-up of 6.8 months. Six weeks after treatment, the mean visual acuity improved by 0.55 lines, an amount that was marginally significant. There was a significant inverse correlation between the baseline visual acuity and the amount of improvement in acuity at 6 weeks. No patient had any treatment-related side effects. Indocyanine green angiography-guided PDT with verteporfin seems to aid in the resolution of exudative detachments in patients with chronic CSC. This treatment was associated with a rapid reduction in subretinal fluid and improvement in visual acuity. Although the follow-up time and number of patients in this pilot study were limited, the encouraging results and lack of complications suggest that further study is indicated.
  Retina 07/2003; 23(3):288-98. · 2.81 Impact Factor
• Article: Optical coherence tomography of branch retinal vein occlusion.

  Richard F Spaide, Jimmy K Lee, James K Klancnik, Nicole E Gross
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  ABSTRACT: To evaluate the incidence of serous retinal detachment (SRD) secondary to a branch retinal vein occlusion (BRVO) by using optical coherence tomography (OCT). Fourteen eyes of 14 patients with a BRVO underwent a detailed history, ophthalmoscopic examination, and fluorescein angiographic evaluation. They were also studied with OCT. The 14 patients included eight women and six men with a mean age of 73.6 +/- 10.5 years (range, 55-90 years). Four eyes were found to have cystoid macular edema by fluorescein angiography, whereas 10 cases were detected by OCT. SRD involving any portion of the macula was found in 10 (71.4%) of the 14 eyes, and SRD extending into the fovea was found in six (42.9%) eyes. Two (14.3%) of the 14 patients also showed a subfoveal hemorrhage that appeared to have gravitated inferiorly through the SRD to the dependent portion of the detachment. That few patients with SRD secondary to a BRVO discovered by ophthalmoscopy have been reported in the literature would suggest that this is an uncommon complication. The authors found with OCT that SRD commonly occurs in BRVO. In addition, subretinal hemorrhage may occur in the context of BRVO, and the authors propose that blood gravitates through the subretinal fluid to settle behind the retina.
  Retina 07/2003; 23(3):343-7. · 2.81 Impact Factor
• Article: Quantitative assessment of photoreceptor recovery in atypical multiple evanescent white dot syndrome.

  Farzin Forooghian, Paul F Stetson, Nicole E Gross, Catherine B Meyerle
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  ABSTRACT: Multiple evanescent white dot syndrome (MEWDS) is part of a spectrum of disease entities known as acute zonal occult outer retinopathy-complex that share photoreceptor disruption as a cardinal feature. Optical coherence tomography (OCT) allows for qualitative assessment of the integrity of the photoreceptor layer via examination of the junction between the photoreceptor inner and outer segments. A patient with atypical MEWDS who demonstrated disruption of the inner segment/outer segment junction during the acute phase of the disease is described. The change in photoreceptor architecture and abnormalities on fundus autofluorescence imaging and microperimetry were restored to normal following resolution of the disease. Using a novel OCT-based method of quantitatively measuring photoreceptor outer segment length, the authors show that photoreceptor outer segment length appears decreased acutely with restoration to normal following disease resolution. OCT can assess photoreceptor recovery, both qualitatively and quantitatively, in patients with MEWDS features.
  Ophthalmic Surgery Lasers and Imaging 41 Suppl:S77-80. · 0.62 Impact Factor