Nicolas Magné

Université Jean Monnet, Saint-Étienne, Rhône-Alpes, France

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Publications (161)551.46 Total impact

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    ABSTRACT: Background: The elderly population in Western countries is growing and constitutes a public health issue. Concomitantly, age-related diseases such as cancer increase. There are few data on the efficacy, tolerability and toxicity of specific anticancer therapy in the very elderly patients; therefore, their management is not standardized. Methods: In this bi-institutional study, we reviewed medical records of patients who received or continued specific anticancer therapy beyond the age of 90 years. Geriatric assessment was not reported for our patients. Twelve patients were enrolled. Their general health condition was good, and half of them were living in elderly institutions. Ten patients had a solid tumor and 2 were treated for hematological malignancies. Most were diagnosed with a locally advanced or metastatic disease, and the goal of treatment was curative for only 1 patient. Six patients received chemotherapy as first-line treatment, 4 patients received targeted therapy and 2 received concomitant chemoradiation. Four patients received a second-line treatment. Results: Despite a significant reduction in treatment posology in half of the patients, 8 acute grade 3/4 toxicities were reported and 2 patients died of treatment-related septic shock. Median duration of first-line treatment was 3.2 months, and progression-free survival ranged from 18 to 311 days. Overall survival ranged from 18 days to 11 years. Conclusion: Aging is a heterogeneous process, and management of elderly patients is a multidisciplinary approach. Geriatric assessment helps to identify older patients with a higher risk of morbidity/mortality and allows to assess the risks and benefits of specific anticancer therapy. The choice of treatment should be based primarily on the expected symptomatic benefit, and treatment should not compromise the quality of life.
    Chemotherapy 11/2015; 61(2):65-71. DOI:10.1159/000441018 · 1.29 Impact Factor
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    ABSTRACT: Context: The European Deprivation Index (EDI), is a new ecological estimate for Socio-Economic Status (SES). This study postulates that Time-To-Treatment could be used as a cancer quality-of -care surrogate in order to identify the association between cancer patient's SES and quality of care in a French comprehensive cancer center. Methods: retrospective mono-centered cohort study. All consecutive incoming adult patients diagnosed for breast cancer(BC), prostate cancer(PC), colorectal cancer (CRC), lung cancer(LC) or sarcoma(S) were included between January 2013 and December 2013. The association of EDI and Time-To-Diagnosis(TTD), as well as Time-To-Treatment(TTT) was analyzed using a cox regression, and a strata analysis per tumor site was performed. Results: 969 patients were included. Primitive tumor site was 505 BC(52%), 169 PC(17%), 145 LC(15%), 116 CRC(12%), and 34 S(4%). Median TTD was 1.41 months (Q1-Q3 0.5 to 3.5 months). Median TTT was 0.9 months (0.4 - 1.4). In a multivariate analysis, we identified the tumor site as a predictive factor to influence TTD, shorter for BC (0.75months, [0.30- 1.9]) than PC (4.69 months [1.6-29.7]), HR 0.27 95%CI= [0.22-0.34], p < 0.001. TTT was also shorter for BC (0.75months [0.4-1.1]) than PC (2.02 [0.9-3.2]), HR 0.32 95%CI= [0.27-0.39], p < 0.001. EDI quintiles were not found associated with either TTT or TTD. Conclusions: Deprivation estimated by the EDI does not appear to be related to an extension of the Time-to-Diagnosis or Time-to-Treatment in our real-life population. Further research should be done to identify other frailty-sensitive factors that could be responsible for delays in care.
    Oncotarget 11/2015; DOI:10.18632/oncotarget.6274 · 6.36 Impact Factor
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    ABSTRACT: Conclusion: The present study demonstrates the feasibility of VMAT in association with platin or cetuximab in HNSCC and reports VMAT-related acute and late toxicities for the first time. Objectives: New radiotherapy techniques, such as Volumetric Modulated Arc Therapy (VMAT) were developed to lower RT-related toxicity. The aim of the present study was to investigate acute and late toxicities of head and neck squamous cell carcinoma (HNSCC) patients treated using VMAT. Methods: This study investigated retrospectively all patients with HNSCC who received VMAT in curative intent. Results: From 2010-2013, 150 patients were treated. Seventy-five patients (50%) received concurrent chemotherapy with VMAT, 51 patients (34%) received VMAT alone and 24 patients (16%) received concurrent cetuximab with VMAT. Mean delivered dose to planning target volume tumor (PTV T), high risk nodes (PTV HNR), low risk nodes (PTV LNR) and prophylactic nodes (PTV PN) were: 65.2 Gy, 62.9 Gy, 55.4 Gy, and 51.5 Gy, respectively. PTV mean coverages were higher than 96.5%. Most common grade 3/4 acute infield toxicities were mucosis (n = 28, 19%), dysphagia (n = 24, 16%), and dermatitis (n = 24, 16%). With a median follow-up of 16.0 months, most common late toxicities were dysphagia (n = 30, 20%), xerostomia (n = 28, 19%), larynx stiff (n = 17, 11%), and skin fibrosis (n = 14, 9%).
    Acta oto-laryngologica 10/2015; DOI:10.3109/00016489.2015.1101783 · 1.10 Impact Factor
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    ABSTRACT: Cervical cancer is one of the most prevalent malignancy and of higher mortality in the world, and is considered a marker of underdevelopment. Conventional radiotherapy is one of the treatments used for this type of cancer. 30 to 40% of patients with similar prognosis factors not respond equally to a comparable standard treatment. The poor response to radiotherapy leads to the development of innovative and effective therapies for cervical cancer locally advanced, metastatic and refractory. A comparative analysis of cervical cancer in the context of other cancers may reveal that it is relatively smaller number of targeted molecular agents that have been tested. Accordingly, a number of biological agents are currently in clinical development for the purpose of, inhibiting angiogenesis, molecularly address EGFR and IGF-1R, modulation of cell cycle, of histone deacetylases, COX-2, mTOR and tumor microenvironment (hypoxia and glycolysis). Within work that we have been developing in cervical cancer with relationship to treatment, we reported that gene expression of IGF1R is a strong predictive marker for lack of response to radiotherapy, patients with expression of IGF1R have 28.6 times higher risk of failure treatment; the expression of IGF-IRβ detected by immunohistochemistry is a prognostic marker that affects overall survival and disease-free survival; the detection and study before treatment of the expression of CAIX, GLUT 1 and HKII, considered as biological factors pre-existing, contributes to infer the metabolic and hypoxic state, as also at the rational use of new modalities in radiotherapy and gene therapy in the regulation of hypoxia.
    International Journal of Gynecological Cancer 10/2015; 25. · 1.95 Impact Factor
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    ABSTRACT: Objective: The objective was to identify acute skin toxicity risk factors linked to anthropometric characteristics of breast cancer patients treated with radiation therapy. Methods: Consecutive patients with breast cancer were enrolled after breast-conserving surgery, and before radiotherapy course. Acute skin toxicity was assessed weekly during the 7 weeks of radiotherapy with the International Classification from National Cancer Institute. Grade 2 defined acute skin toxicity. Patient characteristics and anthropometric measurements were collected. Results: 54 patients were enrolled in 2013. Eight patients (14.8%) had ≥ grade 2 toxicity. The average weight and chest size were 65.5 kg and 93.6 cm, respectively. Bra cup size is significantly associated with a risk of grade 2 dermatitis (OR 3.46, 95% CI (1.29 to 11.92) with p < 0.05). Anthropometric breast fat mass measurements such as thickness of left (OR 2.72, 95% CI (1.08 to 8.26) p = 0.04) and right (OR 2.45, 95% CI (0.99 to 7.27) p = 0.05) axillary fat, are correlated with an increased risk. Distance between pectoral muscle and nipple is a reproducible measurement of breast size, and is associated with acute skin toxicity with significant tendency (OR=2.21; CI 95% (0.97-5.98), p=0.07). Conclusions: Breast size and its different anthropometric measurements (thickness of left and right axillary fat, nipple to pectoral muscle distance) are correlated with the risk of skin toxicity. Advances in knowledge: The present article analyzes several characteristics and anthropomorphic measurements of breast in order to assess breast size. A standardized and reproducible protocol to measure breast volume is described.
    The British journal of radiology 09/2015; 88(1055):20150414. DOI:10.1259/bjr.20150414 · 2.03 Impact Factor
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    ABSTRACT: Objective: The aim of our study was to evaluate emotional distress among women with breast cancer treated by radiotherapy, using a Visual Analogue Scale (an adaptation of the "Distress Thermometer" French version) associated with a Needs Scale with several items, in order to identify patients requiring psychological care. Method: Our sample is composed of 277 women treated for breast cancer with radiotherapy. Our psychological evaluation is made of a first enquiry using a visual analogue distress scale and complemented by a Needs Scale with several items. A grade above 3 on the visual analogue distress scale is a reliable indicator; a grade above 4 out of 20 leads us to propose the patient a consultation with a psychologist. Results: Two hundred and sixty-four female patients with a mean age of 61years are the object of the study. Among them, 59.2% of patients display a disarray of low intensity (psychological suffering graded between 0 and 2) whereas 40% show a grade equal or superior to 3, considered as pathological on a psychological side: 30% of the patients have a grade between 3 et 5 and less than 2% of the patients display a grade reaching 9 or 10. Concerning the Needs Scale, more than 80% of the patients show a total score below 10 out of 20 and we observe a positive correlation between the total score of the Needs Scale with several items and the Visual Analogue Distress Scale score. Conclusion: Our results highlight the difficulty for most of the patients to cope with emotional distress linked to their disease. We discuss the necessity to increase awareness among caregivers on this psychological distress, through the use of simple tools such as a Visual Analogue Scale associated with a Needs Scale, so as to provide a holistic care for women with breast cancer.
    Bulletin du cancer 09/2015; 102(10). DOI:10.1016/j.bulcan.2015.07.004 · 0.60 Impact Factor
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    ABSTRACT: Introduction: Trabectedin proved its efficacy in relapsed advanced soft tissue sarcomas (STS) in 3 multicenter phase II studies with selected patients. The aim of the present study is to investigate trabectedin efficacy and tolerance in a cohort of "real-life" unselected patients with sarcoma. Methods: A single-center analysis was carried out on all consecutive patients with histologically proven unresectable advanced or metastatic STS, who received at least one cycle of trabectedin. Data on efficacy and tolerance were retrospectively reported. Results: From 2004 to 2014, data of 59 patients were reviewed. Median age was 62 years (from 23 to 87). A total of 317 cycles of trabectedin were administered. Twenty-five patients (42%) suffered grade 3-4 hematological toxicity, mainly with neutropenia (22 patients, 37%). Disease control rate was 24%, mainly with stable disease, and 45 patients (76%) experienced disease progression. Median overall survival was 6.6 months (95%CI [4.9-12.6]). Conclusion: Trabectedin might be an option for patients without any other validated alternative, but phase III study evaluating trabectedin+best supportive care (BSC) versus BSC is necessary.
    Bulletin du cancer 09/2015; 102(10). DOI:10.1016/j.bulcan.2015.07.010 · 0.60 Impact Factor
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    ABSTRACT: Several studies have demonstrated that daily physical activity (PA) prevents the development of breast cancer. Our objective was to examine the relationship between PA and clinical and biological tumor characteristics in breast cancer patients in order to determine the impact of energy expenditure (EE) on tumor prognosis. We pooled data from two prospective studies, including a total of 121 breast cancer patients. The measure of PA was done using the self-completion Population Physical Activity Questionnaire, which was answered by each patient. Ten patients harbored triple negative (TN) tumors. The mean body mass index (BMI) in the general population and in patients with TN tumors was 24.3 and 25.6, respectively. The mean daily EE (DEE) was 10,266 kJ × 24 h(-1) in the general population and 11,212 kJ × 24 h(-1) in patients with TN tumors. In the whole population, there was an inverse statistical correlation between BMI and DEE, rest, low PA, and high PA (p = 0.0002, p = 0.003, p < 0001, and p = 0.03, respectively). There was a positive correlation between negative estrogen receptor status and intensive PA (p = 0.041) and DEE (p = 0.007). For TN tumors, there was no significant correlation between BMI and categories of EE. Lifestyle (weight regulation, PA) should be adapted and personalized according to biological, clinical, and epidemiological characteristics of the tumors. © 2015 S. Karger AG, Basel.
    Oncology 08/2015; DOI:10.1159/000437229 · 2.42 Impact Factor
  • Stéphane Vignot · Nicolas Magné ·

    Bulletin du cancer 08/2015; 102(9). DOI:10.1016/j.bulcan.2015.07.001 · 0.60 Impact Factor
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    ABSTRACT: For patients with cervical cancer, intensity-modulated radiation therapy (IMRT) improves target coverage and allows dose escalation while reducing the radiation dose to organs at risk (OARs). In this study, we compared dosimetric parameters among 3-dimensional conformal radiotherapy (3D-CRT), "step-and-shoot" IMRT, and volumetric intensity-modulated arc radiotherapy (VMAT) in a series of patients with cervical cancer receiving definitive radiotherapy. Computed tomography (CT) scans of 10 patients with histologically proven cervical cancer treated with definitive radiation therapy (RT) from December 2008 to March 2010 at our department were selected for this study. The gross tumor volume (GTV) and clinical target volume (CTV) were delineated following the guidelines of the Gyn IMRT consortium that included cervix, uterus, parametrial tissues, and the pelvic nodes including presacral. The median age was 57 years (range: 30 to 85 years). All 10 patients had squamous cell carcinoma with Federation of Gynecology and Obstetrics (FIGO) stage IB-IIIB. All patients were treated by VMAT. OAR doses were significantly reduced for plans with intensity-modulated technique compared with 3D-CRT except for the dose to the vagina. Between the 2 intensity-modulated techniques, significant difference was observed for the mean dose to the small intestine, to the benefit of VMAT (p < 0.001). There was no improvement in terms of OARs sparing for VMAT although there was a tendency for a slightly decreased average dose to the rectum: - 0.65Gy but not significant (p = 0.07). The intensity modulation techniques have many advantages in terms of quality indexes, and particularly OAR sparing, compared with 3D-CRT. Following the ongoing technologic developments in modern radiotherapy, it is essential to evaluate the intensity-modulated techniques on prospective studies of a larger scale. Copyright © 2015 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.
    Medical dosimetry: official journal of the American Association of Medical Dosimetrists 07/2015; DOI:10.1016/j.meddos.2015.06.002 · 0.76 Impact Factor
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    ABSTRACT: Lung cancer is a major public health concern worldwide. Progress in improving 5-year survival is lagging behind comparable survival rates in other common cancers. The majority of patients with locally advanced non-small cell lung cancer (NSCLC) are not suitable for surgical resection, hence the major role of radical radiotherapy. Advances in radiotherapy techniques allow targeted treatment of the disease, whilst minimizing the dose to organs at risk. Recent research into fractionation schedules, with hyperfractionated and accelerated radiotherapy regimens has been promising. Platinum-based chemotherapy has long been the standard of care for the initial treatment of advanced NSCLC. However, if radical radiotherapy remains the cornerstone of treatment for patients with unresectable advanced NSCLC either as single modality treatment or with concomitant chemotherapy, advances in understanding of tumor molecular biology and targeted drug development should bring targeted agents into the NSCLC management. The development of numerous therapeutic approaches has made the locally advanced NSCLC world change. An up-to-date overview of the current literature on updated chemotherapeutic agents, targeted therapy, immunotherapy, radiotherapy in stage III NSCLC is provided. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    Critical reviews in oncology/hematology 06/2015; DOI:10.1016/j.critrevonc.2015.05.020 · 4.03 Impact Factor
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    ABSTRACT: Intravenous vinflunine 320 mg/m(2) every 3 weeks plus best supportive care resulted in better overall survival in comparison with best supportive care alone for eligible patients with failure of prior therapy with locally advanced or metastatic transitional cell cancer of urothelial tract (TCCU). The objective of the present study was to describe our real-life experience of vinflunine for treatment of patients with TCCU. We retrospectively investigated all patients with TCCU who received at least 1 cycle of vinflunine. Nineteen patients were treated between May 2010 and March 2014 in a compassionate-use program. Performance status was poor in our real-life cohort, with 6 patients (32%) with an Eastern Cooperative Oncology Group performance status of 2. Median duration of vinflunine treatment was 2.4 months (range, 0-4.3 months), and median number of cycles was 3 (range, 1-6). Total response rate was 32%, with partial responses only. Disease control rate was 53%, with a median duration of 7.7 months (range, 6.0-9.4 months). Median progression-free survival was 87 days, or 2.9 months (range, 0.7-11.7 months). After vinflunine treatment, 42% of patients received from 1 to 3 additional lines of chemotherapy. The most frequent grade 4 toxicities were constipation (26%), with 3 intestinal obstructions (16%) and 1 mechanical ileus (5%); and asthenia and fatigue (21%). Vinflunine, as a TCCU second-line chemotherapy, brings benefits, particularly in cases where there is no alternative treatment. Copyright © 2015 Elsevier Inc. All rights reserved.
    Clinical Genitourinary Cancer 06/2015; DOI:10.1016/j.clgc.2015.05.008 · 2.32 Impact Factor
  • Jean-Jacques Mazeron · Nicolas Magne · Juliette Thariat ·

    Bulletin du cancer 05/2015; 102(6). DOI:10.1016/j.bulcan.2015.04.020 · 0.60 Impact Factor
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    ABSTRACT: We report the case of an 80-year-old patient who presented with a progressive prostate metastatic cancer with poor performance status. The patient had already benefitted from docetaxel and abiraterone. A new line of chemotherapy by cabazitaxel was started with good response, and there was a dramatic improvement in general status and pain symptoms. Age and performance status alone should not be limiting decision factors for elderly cancer patients. © 2015 S. Karger AG, Basel.
    Chemotherapy 05/2015; 60(5):300-301. DOI:10.1159/000377620 · 1.29 Impact Factor
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    ABSTRACT: There are only scarce data on the optimal management of patients who present with a bladder carcinoma and who are aged 90 years and older. We retrospectively reviewed records from radiotherapy departments from two university hospitals, two private centers and one public center to identify patients who underwent radiotherapy for bladder cancer over the past decade and who were aged 90 years or older. From 2003 to 2013, 14 patients aged 90 years or older receiving RT for bladder malignant tumors were identified. Mean age was 92.7 years. Ten patients (71 %) had a general health status altered (PS 2-3) at the beginning of RT. A total of 14 RT courses were delivered, including six treatments (43 %) with curative intent and eight treatments (57 %) with palliative intent. Palliative intent mainly encompassed hemostatic RT (36 %). At last follow-up, two patients (14 %) experienced complete response, one patient (7 %) experienced partial response, three patients (21 %) had their disease stable, and three patients (21 %) experienced tumor progression, of whom two patients with the progression of symptoms. There was no reported high-grade acute local toxicity in 14 patients (100 %). One patient experienced delayed grade 2 toxicity with pain and lower urinary tract symptoms. At last follow-up, seven patients (50 %) were deceased. Cancer was the cause of death for five patients. Hypofractionated radiotherapy remains feasible for nonagenarians with bladder cancer. Further investigations including analysis of geriatric comorbidities and impact of treatments on quality of life should be conducted.
    International Urology and Nephrology 05/2015; 47(7). DOI:10.1007/s11255-015-0999-8 · 1.52 Impact Factor
  • Ronan Flippot · Moumini Kone · Nicolas Magné · Stéphane Vignot ·
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    ABSTRACT: Une dérégulation de la voie FGF (fibroblast growth factor)/FGFR (fibroblast growth factor receptor) entraîne la promotion de mécanismes protumoraux : prolifération, transition épithélio-mésenchymateuse, modifications du cytosquelette, migration, angiogenèse. La dérégulation de cette voie à un stade précoce est rapportée dans de nombreux cancers et peut être responsable de l’acquisition du phénotype tumoral. Il est nécessaire de préciser les voies d’aval et les interconnexions de la signalisation FGF/FGFR pour mieux comprendre son potentiel oncogénique. Nous décrirons l’implication de cette voie dans les différents types tumoraux concernés. Les mécanismes de carcinogenèse seront étudiés en prenant l’exemple du mélanome, pour lequel une dérégulation de la voie FGF/FGFR est présente et considérée comme driver dans près de 90 % des cas. La dérégulation de FGF/FGFR est une cible thérapeutique potentielle. De nombreux agents sont en développement, inhibant cette voie de manière sélective ou dans le cadre d’un ciblage multiple. Les essais récents montrent des résultats décevants chez des patients non sélectionnés, mais prometteurs sur des tumeurs présentant des altérations de la voie FGF/FGFR. Une sélection soigneuse des patients est donc primordiale pour une évaluation pertinente de ces nouveaux traitements.
    Bulletin du cancer 05/2015; 102(6). DOI:10.1016/j.bulcan.2015.04.010 · 0.60 Impact Factor
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    ABSTRACT: La infección por el virus del papiloma humano es un evento inicial importante del proceso tumoral en el carcinoma de cuello uterino. La presencia del virus del papiloma humano de tipo 16 (HPV- 16), se ha reportado como un factor que incide negativamente en la respuesta a la radioterapia. Se conoce la variación en la secuencia del genoma del HPV-16 en diferentes poblaciones étnicas y hay datos científicos que sugieren que las variantes no europeas tienen un mayor potencial oncogénico, aunque aún no hay reportes sobre la presencia de variantes del HPV-16 y su relación con la respuesta al tratamiento. El objetivo de este estudio fue detectar la presencia de variantes del HPV-16 y analizar su relación con la respuesta al tratamiento. La detección y el estudio de variantes del HPV-16 se hizo mediante el análisis de las regiones E6 y LCR con PCR-SSCP y secuenciación directa en biopsias tomadas antes del tratamiento. La respuesta completa a la radioterapia tres meses después de terminado el tratamiento se definió como ausencia de enfermedad residual. De un grupo de 59 pacientes con cáncer cervical en estadios IIB a IVB, 34 (57,6 %) fueron positivas para HPV-16 y se identificaron dos grupos de variantes: un primer grupo de 30 (88,2 %) pacientes presentaron la variante europea, y un segundo grupo de cuatro pacientes presentó la variante no europea, y de estas, tres correspondían a la variante asiático-americana. De las 34 pacientes, 15 recibieron radioterapia completa, ocho con respuesta completa, cuatro con respuesta parcial y en tres persistió el tumor. La distribución de las variantes europeas y no europeas fue similar en las pacientes que respondieron a la radioterapia y en aquellas que no; sin embargo, es importante tener en cuenta que la variante natural L83V (E-350G), entre otras, contribuye a la formación de tumores por degradación del gen p53, y que la variante E R10G acorta significativamente la vida media de p53, interrumpiendo su acción en la apoptosis después de la irradiación.
    Biomédica: revista del Instituto Nacional de Salud 05/2015; 35:24. · 0.55 Impact Factor
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    ABSTRACT: Le vieillissement de la population française impose aux radiothérapeutes le défi de traiter des patients de plus en plus âgés et ainsi d’adapter leur traitement. Inenvisageable il y a 30 ans, la radiothérapie concerne aussi aujourd’hui des patients âgés de plus de 90 ans. Des outils d’évaluation oncogériatrique se sont développés ces dernières années, sans pour autant totalement changer, en pratique, les décisions thérapeutiques : si l’évaluation oncogériatrique influence la décision finale de RCP, elle ne définit pas de nouveaux volumes cibles, de nouvelles doses, ou des fractionnements différents. Hormis quelques localisations, il n’existe actuellement aucun consensus sur les traitements adaptés à la population gériatrique, ce qui complique la prise en charge. La présente revue a pour objectif de réaliser un tour d’horizon des publications étudiant l’efficacité et la tolérance de la radiothérapie chez le sujet âgé (> 70 ans) ou très âgé (> 90 ans).
    Bulletin du cancer 03/2015; 102(6). DOI:10.1016/j.bulcan.2015.03.001 · 0.60 Impact Factor
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    ABSTRACT: Pulsed-dose-rate (PDR) brachytherapy is a recent brachytherapy modality combining the radiobiological advantages of low-dose-rate (LDR) brachytherapy with increased possibilities of dose optimization and radiation safety. However, treatment duration remains protracted, as the prescribed dose is typically delivered through pulses that do not exceed 0.5 Gy/h for critical organs. It is frequently used for the treatment of gynaecological malignancies. Although, the relationship between thrombosis and cancer is well known, specific data on thromboembolic events during brachytherapy are scarce. We report two cases of major thromboembolic events during brachytherapy treatment for gynaecological malignancies. We discuss the possible causal relationship between brachytherapy procedures and the occurrence of thromboembolic events, drawing a preventive practical attitude.
    Journal of Contemporary Brachytherapy 02/2015; 7(1):76-8. DOI:10.5114/jcb.2015.48580 · 1.28 Impact Factor
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    ABSTRACT: De nombreuses données sont présentées chaque année durant les principaux congrès internationaux en oncologie redessinant l’état de nos connaissances. Cet article, proposé par le comité de rédaction du Bulletin du Cancer, propose d’en reprendre les principales données avec un recul de quelques mois afin d’identifier parmi ces résultats ceux qui sont susceptibles d’avoir un impact immédiat ou prochain sur les pratiques cliniques.
    Bulletin du cancer 01/2015; 102(1). DOI:10.1016/j.bulcan.2014.11.002 · 0.60 Impact Factor

Publication Stats

2k Citations
551.46 Total Impact Points


  • 2015
    • Université Jean Monnet
      Saint-Étienne, Rhône-Alpes, France
  • 2012-2015
    • Institut de cancérologie Lucien-Neuwirth
      La Fouillouse, Rhône-Alpes, France
  • 2014
    • Claude Bernard University Lyon 1
      Villeurbanne, Rhône-Alpes, France
  • 2013
    • Université Paris-Sud 11
      Orsay, Île-de-France, France
  • 2012-2013
    • University of Lyon
      Lyons, Rhône-Alpes, France
  • 2007-2012
    • Institut de Cancérologie Gustave Roussy
      • Department of Radiotherapy
      Villejuif, Île-de-France, France
  • 2004-2011
    • Institut Jules Bordet
      • Department of Nuclear Medicine
      Bruxelles, Brussels Capital Region, Belgium
  • 2009-2010
    • Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
      Lutetia Parisorum, Île-de-France, France
  • 2006
    • Université Libre de Bruxelles
      • Bordet Institute
      Bruxelles, Brussels Capital Region, Belgium
  • 2000-2006
    • Centre Antoine-Lacassagne
      Nice, Provence-Alpes-Côte d'Azur, France