[show abstract][hide abstract] ABSTRACT: Non-specific abnormalities in liver function tests might accompany the clinical course of hyperthyroidism. Hyperthyroidism can cause the elevation of hepatic enzymes and bilirubin. Jaundice is rare in overt hyperthyroidism, especially in subclinical hyperthyroidism. On the other hand, the use of anti-thyroid drugs has rarely been associated with toxic hepatitis and cholestatic jaundice.
Here we present two cases of cholestasis that accompanied two distinct forms of clinical hyperthyroidism. The first patient had a clinical presentation of severe cholestasis in the absence of congestive failure related to hyperthyroidism. The second case had developed intrahepatic cholestasis in the presence of subclinical hyperthyroidism, and improved with rifampicin treatment.
Hyperthyroidism should be a consideration in non-specific liver dysfunction.
[show abstract][hide abstract] ABSTRACT: Growth hormone (GH) is a classic anabolic hormone that promotes skeletal growth. It is secreted until late in life. Although pronounced metabolic effects of GH were well documented in both healthy and hypopituitary adults, until the second half of 1980’sGH deficiency in adult life were not considered as a clinical problem for most endocrinologists. Lately it has been observed that the cessation of GH treatment in growth retarded children after puberty resulted in various psychosocial and physical problems. In recent years, adult GH deficiency (GHD) has been acknowledged as a well defined clinical syndrome, consisting of altered body composition, impaired lipid profile, reduced muscle strength, reduced bone mineral density, and a reduced sense of psychological well-being. GHD in adult shows striking similarities with syndrome X, thus carries a high risk for cardiovascular disease. GH replacement can improve some abnormalities of body composition and metabolic perturbations as demonstrated by various studies.