Marcin Nastaj

Publications of Marcin Nastaj

• [Processes of free radical lipid peroxidation with a particular regard to the role of paraoxonase-1 in the pathogenesis of multiple sclerosis].

  Authors: Jerzy Berbecki, Krystyna Mitosek-Szewczyk, Jacek Kurzepa, Marcin Nastaj, Katarzyna Łobejko, Zbigniew Stelmasiak

  Wiadomości lekarskie (Warsaw, Poland : 1960). 01/2011; 64(1):31-6.

  Oxidative stress is an imbalance between free radicals production and antioxidant defences. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can attact and demage a variety ofOxidative stress is an imbalance between free radicals production and antioxidant defences. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can attact and demage a variety of critical biological molecules, including lipids, essential cellular proteins and DNA and may be exert in pathogenesis of many disorders. Products of lipid peroxidation can be easily reliably detected in biological fluids and tissues, yielding sensitive and specific signals of lipid peroxidation occurred in vivo. Those products are: isoprostanes (isoP) dimalonealdehyde (MDA), 4-hydroxynonenal (4-HNE). Paraoxonase-1 (PON-1) play a key role in defence of lipid peroxidation. PON-1 is an serum enzyme bound up with high density lipoproteins (HDL). The aim of this work is to discuss the role of oxidative stress in the pathogenesis of multiple sclerosis.

• Oligoclonal bands measured in unconcentrated cerebrospinal fluid and other biochemical parameters in multiple sclerosis.

  Authors: Jacek Kurzepa, Marcin Nastaj, Krystyna Mitosek-Szewczyk, Halina Bartosik-Psujek, Zbigniew Stelmasiak

  Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. 02/2004; 59(2):392-6.

  Various biochemical parameters of cerebrospinal fluid (CSF) obtained from sixty-nine patients with RRMS (relapse-remitting MS) were compared in this study. Total protein level, white blood cellsVarious biochemical parameters of cerebrospinal fluid (CSF) obtained from sixty-nine patients with RRMS (relapse-remitting MS) were compared in this study. Total protein level, white blood cells (WBC) count and presence of oligoclonal bands (OB) in CSF were examined. The presence of OB in unconcentrated CSF using an isoelectrofocusing assay on agarose gels and silver staining were measured in 72 percent of patients. The average CSF total protein level measured by Lowry assay was 269 mg/l (range from 61 to 712 mg/l). The mean level of white blood cells (WBC) was higher than in general population and it was 12 cells/microl. We found an increased level of WBC count among patients with the presence of oligoclonal bands in CSF.

• Vitamin B12 deficiency as a potential cause of dementia.

  Authors: Maria Pilarczyk, Jacek Porebiak, Andrzej Fidor, Marcin Nastaj, Jacek Jaworski, Zbigniew Stelmasiak

  Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. 02/2004; 59(2):408-9.

  There is a patient case with dementia and brain MRI massive abnormalities, probably in the course of vitamin B12 deficiency.

• Thymectomy as an effective treatment in myasthenia.

  Authors: Maria Pilarczyk, Marcin Nastaj, Andrzej Fidor, Jacek Jaworski, Jacek Porebiak, Jacek Kurzepa, Zbigniew Stelmasiak

  Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. 02/2004; 59(2):369-70.

  The paper describes a patient case with early diagnosed myasthenia introduced, who after thymectomy and postsurgical pharmacology achieved a total remission of the disease within six years.

• Diagnosis: miner's nystagmus.

  Authors: Maria Pilarczyk, Jacek Jaworski, Andrzej Fidor, Marcin Nastaj, Jacek Porebiak, Zbigniew Stelmasiak

  Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. 02/2004; 59(2):207-8.

  We present the patient with pendular nystagmus. The condition is secondary to long-term work as an underground coal miner. The issue is worth describing because of its rare presence in contemporaryWe present the patient with pendular nystagmus. The condition is secondary to long-term work as an underground coal miner. The issue is worth describing because of its rare presence in contemporary either neurological or ophthalmological literature.