Publications (4)1.44 Total impact
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Article: Synthesis and Biological Evaluation of Isomeric Derivatives of Naturally Occurring Spatozoate.
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ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.ChemInform 08/2006; 37(38). -
Article: Synthesis and biological evaluation of isomeric derivatives of naturally occurring spatozoate.
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ABSTRACT: An isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b-2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. Compound 2g was found to be the most potent cytotoxic agent with a LD50 = 8.98 microg/ml. In a bactericidal assay the compounds showed a broad spectrum of activities. Compound 2a has a very promising fungicidal activity against Microsporum canis.Arzneimittel-Forschung 02/2006; 56(5):351-8. · 0.72 Impact Factor -
Article: Efficient Synthesis of Isobenzofuran‐1(3H)‐ones (Phthalides) and Selected Biological Evaluations.
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ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.ChemInform 01/2006; 37(7). -
Article: Efficient synthesis of isobenzofuran-1(3H)-ones (phthalides) and selected biological evaluations.
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ABSTRACT: The studies presented here deal with the convenient and efficient one-step conversion of o-alkylbenzoic acids into their corresponding isobenzofuran-1 (3H)-ones (phthalides) using NaBrO3/NaHSO3 in a two-phase system. A range of o-alkylbenzoic acids was used with the object of getting a variety of phthalide derivatives as multipurpose biologically active compounds. Seventeen phthalides have been synthesized and tested for cytotoxicity, antibacterial and antifungal activities. Some of these compounds showed promising cytotoxic effects against Artemia salina. Compounds 4j-4p were highly active against Gram-negative and Gram-positive bacteria among all tested compounds. In the fungicidal assay, the compounds showed a broad spectrum of activity against six fungi. All compounds were characterized via elemental analysis, UV, IR, mass and-NMR spectroscopy.Arzneimittel-Forschung 02/2005; 55(10):588-97. · 0.72 Impact Factor
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- Arzneimittel-Forschung (2)
- ChemInform (2)
Institutions
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2005–2006
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Eberhard-Karls-Universität Tübingen
- Institute of Inorganic Chemistry
Tübingen, Baden-Wuerttemberg, Germany
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