Mehmet Emre Atabek

Necmettin Erbakan Üniversitesi, Conia, Konya, Turkey

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Publications (130)142.87 Total impact

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    ABSTRACT: Abstract Aim: In this study, parameters of metabolic syndrome and dehydroepiandrosterone sulfate (DHEAS) levels in obese children and adolescents were evaluated and the associations between these factors were analyzed. Method: One hundred obese and 40 healthy children/adolescents were included in the study. Pubertal stages, anthropometric and blood pressure measurements were recorded. Levels of fasting serum lipids, glucose, insulin, and DHEAS, and liver function tests were determined. Carotid intima-media thickness (CIMT) was measured using two-dimensional echocardiography. Steatorrhoeic hepatosis was evaluated using abdominal ultrasonography in the obese group. Results: Mean body weight, body mass index, waist, hip circumference, waist/hip ratio, homeostatic model assessment of insulin resistance, triglycerides, high-density lipoprotein cholesterol, alanine transferase, DHEAS, and CIMT values were significantly higher in the obese group than in the controls. DHEAS levels were found to be positively correlated with waist circumference, waist/hip ratio, and CIMT. Conclusion: Early determination of metabolic and cardiac dysfunction in obese children is important for the prevention of future complications. Since in this study we found a strong association between DHEAS levels and obesity-related metabolic and cardiovascular risk factors, we believe that this may lead to increased interest in further studies of DHEAS in the search for new treatment approaches.
    Journal of pediatric endocrinology & metabolism: JPEM 11/2014; · 0.75 Impact Factor
  • Mehmet Emre Atabek, Beray Selver Eklioglu, Nesibe Akyürek
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    ABSTRACT: The aim of this study was to identify which metabolic syndrome criteria (WHO or IDF) better reflect the presence of non-alcoholic fatty liver disease (NAFLD) and to determine the prevalence of metabolic syndrome (MS) and NAFLD.
    Eating and weight disorders: EWD 05/2014; · 0.53 Impact Factor
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    ABSTRACT: The aim of the present study was to determine the level of ischemia-modified albumin (IMA) in children with epileptic seizures (ESs) and its relation with the seizure duration.
    Pediatric emergency care. 05/2014;
  • Journal of pediatric endocrinology & metabolism : JPEM. 05/2014;
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    ABSTRACT: Abstract Background: Childhood obesity is a cardiovascular risk factor. Objective: Epicardial adipose tissue (EAT) thickness, carotid intima-media thickness (IMT) and cardiac functions of obese children and their correlations were evaluated. Subjects: Five hundred obese children and 150 age- and sex-matched healthy controls. Methods: Anthropometric, laboratory data and echocardiographic measurements of IMT, EAT and cardiac functions were determined. Results: Increased M-mode echocardiographic measurements, E/e' ratios, Tei index values and decreased E/A and e'/a' ratios (where E and A are early and late mitral/tricuspid diastolic velocities, respectively, and e' and a' are peak early diastolic and peak atrial systolic myocardial velocities, respectively), were determined in the obese group. Also, carotid artery IMT and EAT thickness were significantly higher in obese children. Carotid artery IMT, EAT thickness and left ventricular mass (LVM) were found to be strongly associated with Tei index values. Conclusion: Obesity is a major risk factor for cardiovascular diseases. In our study, we showed that obese children have early subclinical systolic and diastolic dysfunctions. Also, these cardiac impairments are correlated with the increase in IMT, EAT thickness and LVM.
    Journal of pediatric endocrinology & metabolism : JPEM. 04/2014;
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    ABSTRACT: Abstract Background: The aim of our study was to evaluate the associations between vitamin D deficiency, the atherosclerosis and metabolic syndrome. Methods: Two hundred and forty-seven obese children and adolescents, 8-16 years of age (body mass index>95 p) were included in the study. Anthropometric measurements, blood pressure measurements, lipid profile, vitamin D level and carotid intima media thickness (c-IMT) were measured. MS was diagnosed according to IDF criteria. Results: The prevalance of vitamin D deficieny in obese children and adolescent was 46.6%. Low levels of vitamin D were associated with increased carotis intima media thickness and metabolic syndrome (p=0.03, p=0.04, respectively). For clinical cardiovascular risk factors, mutivariable regression analyses showed that low vitamin D level was best predictor of c-IMT. Conclusions: In this study we showed an association between low vitamin D status and atherosclerosis independent of traditional risk factors in obese children and adolescents.
    Journal of pediatric endocrinology & metabolism : JPEM. 04/2014;
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    ABSTRACT: Obesity and hypertension are associated with structural and functional cardiac change in children and adults. The aim of the study is to evaluate the effect of hypertension and obesity on left ventricular geometric patterns and cardiac functions assessed by conventional and Doppler echocardiography. Four hundred and thirty obese children, aged 6-17 years and 150 age and sex-matched healthy controls, were included in the study. Left ventricular geometry was classified as concentric hypertrophy, eccentric hypertrophy, concentric remodeling and normal geometry. Concentric hypertrophy group had the worst subclinical systolic and diastolic cardiac functions among all left ventricular geometric patterns. BMI and total adipose tissue mass are the predictors of abnormal ventricular geometry. Apart from the increase in carotid intima-media and epicardial adipose tissue thicknesses in different left ventricular geometry patterns, they are not predictable for abnormal geometry. The variety of alterations in cardiac function and morphology that has been observed in obese adults, appears to start earlier in life. Obesity and hypertension were clearly associated with the left ventricular geometry. Also, subclinical systolic and load-depended diastolic dysfunctions can be detected in obese hypertensive children with concentric hypertrophy.
    Journal of Hypertension 04/2014; · 4.22 Impact Factor
  • Nesibe Akyürek, Mehmet Emre Atabek, Beray Selver Eklioglu
    Journal of pediatric endocrinology & metabolism : JPEM. 01/2014;
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    ABSTRACT: Type 1 diabetes in children predicts a broad range of later health problems including an increased risk of cardiovascular morbidity and mortality. This study aimed to evaluate whether nocturnal hypertension and impaired nocturnal dipping affect atherosclerosis in children and adolescents with type 1 diabetes and to investigate the relationship between atherogenic risk factors and carotid intima-media thickness (CIMT). One hundred fifty-nine type 1 diabetic patients and 100 healthy controls were included in the study. We investigated metabolic and anthropometric parameters such as body mass index (BMI), waist circumference, fasting glucose and insulin, serum lipids, 24h ambulatory blood pressure monitoring (ABPM), and CIMT and compared these with those in control subjects (CS). No difference was found between type 1 diabetic patients and CS in age, weight, waist/hip ratio, triglyceride, HDL-cholesterol level. However in children with type 1 diabetes, total cholesterol (p=0.016),and LDL-cholesterol (p=0.002) levels and CIMT (P<0.001) were greater than those of controls. It was determined that 10% of type 1 diabetic patients had dyslipidemia. In 23.2% of type 1 diabetic patients, ABPM showed arterial hypertension. CIMT was significantly higher in the hypertensive group than in the nonhypertensive group (P=0.003). Twenty-three (14.4%) diabetic patients had nocturnal hypertension. CIMT was significantly greater in the nocturnal hypertensive group (p=0.023). Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dipping was significantly different in diabetic patients (P<0.001). CIMT was correlated positively with Hba1c (r=0.220, p=0.037), and negatively with SBP dipping (r=-0.362, p=0.020) in the diabetic patients. In stepwise regression analysis, Hba1c and SBP dipping emerged as a significant predictor of CIMT (β=0.300, p=0.044, β=0.398 p=0.009) contributing to 15.58% of its variability. These results provide additional evidence for the presence of subclinical cardiovascular disease (CVD) and its relation to hypertension in type 1 diabetic patients. They also indicate a significant relation between nocturnal hypertension, SBP dipping and increased arterial stiffness. It is also important to note that our findings reveal significant relationships between HBA1c cardiovascular changes and underline the importance of glucose control to predict CVD.
    Journal of diabetes and its complications 10/2013; · 2.11 Impact Factor
  • Mehmet Emre Atabek, Nesibe Akyürek, Beray Selver Eklioglu
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    ABSTRACT: Patients with diabetes mellitus (DM) are at risk for vulvovaginal candidasis. The aim of this study was to determine the species-specific prevalence rate and risk of candidiasis in patients with type 1 DM. Children aged between 8-16 years were included in the study. Clinical and laboratory features of diabetes and evidence of genital symptoms were recorded. Vaginal swabs were taken from patients and placed on Sabouraud's dextrose agar and incubated. Following fasting overnight for 12 hours venous blood samples were taken simultaneously for analyses of blood glucose, HbA1c, and lipid profile. A simple 1-time fluconazole treatment regimen was used to treat patients with vulvo-vaginal candidiasis. Candida species were isolated in 30 of 76 (39%) swabs of patients with type 1 DM. Subjects who had candida colonization and candidiasis were all acute. The predominant candida species isolated from patients with type 1 DM were C.albicans 50%, C. glabrata 36.6%, C.crusei 3.3%, C.spesies 6.6%, and C.dubliniensis 3.3%. 42 patients had symptoms.The prevalence of candidiasis in symptomatic patients was 59.2%. Subjects with vulvo-vaginal candidiasis had higher mean HbA1c when compared to those who had no such infection (P = .047). There seems to be a significant link between hyperglycemia and vulvo-vaginal candidiasis in patients with type 1 DM. Improving glucose control may reduce the risk of candidiasis and potentially symptomatic infection among children with diabetes. Because of high rate of colonization with candida species in diabetes, patients should undergo periodic screening for genital candidiasis.
    Journal of pediatric and adolescent gynecology 10/2013; 26(5):257-60. · 0.90 Impact Factor
  • Beray Selver Eklioglu, Mehmet Emre Atabek, Nesibe Akyürek
    Journal of pediatric endocrinology & metabolism: JPEM 09/2013; · 0.75 Impact Factor
  • Mehmet Emre Atabek
    Journal of pediatric endocrinology & metabolism: JPEM 07/2013; · 0.75 Impact Factor
  • Mehmet Emre Atabek
    Journal of pediatric endocrinology & metabolism: JPEM 07/2013; · 0.75 Impact Factor
  • Source
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    ABSTRACT: Objective: Our aim was to reveal a change in the prevalence of metabolic syndrome in the province of Konya in five years. Methods: We studied 202 obese children and adolescents (body mass index > 95th percentile) aged between 7 and 18 years. The diagnosis of impaired glucose tolerance, type 2 diabetes, and metabolic syndrome were defined according to the modified WHO criteria adapted for children. Results: Metabolic syndrome was found in 56.4 % with a significantly higher rate among adolescents aged 12-18 years (63.2%) than among prepubertal children aged 7-11 years (47%) (p=0.01). The prevalence figures for insulin resistance, glucose intolerance, and type 2 diabetes were 60, 8, and 2% among prepubertal children and 81.8, 12.8, and 0% among adolescents, respectively. The prevalence of fasting hyperinsulinemia in adolescents was significantly higher than in prepubertal children (p < 0.001). Hypertension was significantly more common in adolescents (42.8%) than in prepubertal children (32.9%) (p =0.04). Conclusions: We found that the incidence of metabolic syndrome in the city center of Konya approximately doubled in the last five years with increased rates of morbidity and abnormal lipid profiles.
    Journal of Clinical Research in Pediatric Endocrinology 07/2013;
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    ABSTRACT: Patients with Turner syndrome (TS) have an increased risk of cardiovascular morbidity. 29 TS and 25 healthy control subjects (CS) were included in the study. We investigated body mass index, waist circumference, fasting glucose and insulin, homeostatic model assessment (HOMA) index, serum lipids, oral glucose tolerance test, 24-h ambulatory blood pressure (BP) monitoring, and carotid intima-media thickness (CIMT) and compared them with CS. 28 % (N = 7) of TS had insulin resistance (IR), and 36 % (N = 9) had IGT. Mean systolic BP and diastolic BP (DBP) dip were 7.24 ± 3.97 % and 11.84 ± 6.2 %, respectively. CIMT was greater in TS than in CS (p = 0.00). CIMT was correlated positively with fasting insulin, HOMA index, and insulin-sensitivity check index (r = 0.563, p = 0.015; r = 0.603, p = 0.008; and r = 0.623, p = 0.006, respectively) and negatively with fasting glucose-to-insulin ratio and DBP dipping (r = -0.534, p = 0.022; r = -0.534, p = 0.00, respectively) in the two groups combined. These results provide additional evidence for the presence of subclinical cardiovascular disease and its relation to hypertension in TS. They also indicate a significant relation between DBP dipping and increased arterial stiffness. It is also important to note that our findings show significant relationships between insulin sensitivity and cardiovascular changes and underline the importance of insulin resistance for predicting cardiovascular disease.
    Pediatric Cardiology 06/2013; · 1.20 Impact Factor
  • Mehmet Emre Atabek
    Hormone Research in Paediatrics 06/2013; · 1.55 Impact Factor
  • Journal of pediatric endocrinology & metabolism: JPEM 05/2013; · 0.75 Impact Factor
  • Mehmet Emre Atabek
    Journal of pediatric endocrinology & metabolism: JPEM 05/2013; · 0.75 Impact Factor
  • Mehmet Emre Atabek
    Journal of pediatric endocrinology & metabolism: JPEM 05/2013; · 0.75 Impact Factor
  • Mehmet Emre Atabek
    [Show abstract] [Hide abstract]
    ABSTRACT: No abstract available.
    Journal of pediatric endocrinology & metabolism: JPEM 03/2013; · 0.75 Impact Factor

Publication Stats

860 Citations
142.87 Total Impact Points

Institutions

  • 2013–2014
    • Necmettin Erbakan Üniversitesi
      Conia, Konya, Turkey
  • 2002–2012
    • Selcuk University
      • • Division of Pediatric Endocrinology
      • • Department of Pediatrics
      • • Faculty of Medicine
      Konya, Konya, Turkey
  • 2003–2008
    • Erciyes Üniversitesi
      • Department of Pediatrics
      Melikgazi, Kayseri, Turkey