L F Mota

Autonomous University of Nuevo León, San Nicolás de los Garza, Nuevo León, Mexico

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Publications (12)28.21 Total impact

  • Periodontology 2000 02/2007; 9(1):7 - 13. · 4.01 Impact Factor
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    ABSTRACT: Periodontitis is characterized by the formation of periodontal pockets and bone loss. Although the basic treatment emphasizes the control of bacterial plaque, the clinician is confronted with the need to correct soft and/or hard tissue defects that develop as a consequence of the disease. This article reviews the current status of regenerative approaches in treating soft and hard tissue defects (based mainly on findings from our own laboratory) and assessed the global applicability of these procedures. Many different techniques have been suggested to treat those defects with, in general, a high degree of success. From the present knowledge it can be concluded that periodontal soft and hard tissue regeneration is possible. Treatment of areas with localized gingival recession or insufficient keratinized gingiva can be achieved with soft tissue grafts or pedicle flaps, as well as with the use of dermal allografts. The treatment of hard tissue defects around teeth and implants can be approached using different types of bone grafts, guided tissue or bone regeneration, or a combination of these. The predictability of many of these therapies, however, still needs to be improved. Since most of these techniques are sensitive, specific, and expensive, their present universal application is limited.
    American journal of dentistry 11/2002; 15(5):339-45. · 1.06 Impact Factor
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    ABSTRACT: A genetic polymorphism in the interleukin 1 gene has been implicated as a factor in determining the severity of adult periodontitis. Among white Europeans, the prevalence of genotype-positive subjects has been reported to be around 30%. The purpose of this study was to assess the prevalence of genotype-positive individuals in a Hispanic population. Fifty Mexicans were evaluated for their interleukin 1 genotype with a commercially available test. Subjects were divided into groups, as determined by their genotype (positive or negative), and were then analyzed according to age, sex, and smoking habits. Thirteen of 50 subjects were genotype positive, a prevalence of 26%. The most common polymorphisms found in genotype-positive subjects were allele 1.2 for the IL 1A gene and allele 1.2 for the IL 1B gene. When only subjects older than 30 years were evaluated, the prevalence of genotype-positive individuals was 31%. The prevalence of genotype-positive subjects in a Hispanic population was 26%, similar to the prevalence found among ethnic populations from or descended from Northern, Central, and Southern Europe.
    Quintessence international 04/2002; 33(3):190-4. · 0.71 Impact Factor
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    ABSTRACT: The goal of this investigation was to histologically evaluate the healing and revascularization of the subepithelial connective tissue graft in dogs. Six beagle dogs were used in this study. Recession defects were surgically created on maxillary left P2 and right P2, and maxillary and mandibular left central and lateral incisors. The defects were left untreated for 35 days. After elevating a split thickness flap, the graft was harvested from the palate and placed over the denuded root surfaces. The flap was then coronally repositioned and sutured. Three dogs provided the specimens for 7- and 14-day time points and 3 dogs for 28- and 60-day time points. The animals were sacrificed and the blocks obtained were divided in half. One half was processed following the Spalteholtz method and the other was processed for routine histologic examination. At 7 days, a clot was present at the demarcation zones and it was more organized at 14 days. At 28 days, the junctional epithelium was formed and the demarcation zones could not be delineated. At 60 days, the oral epithelium had regained its normal appearance. The attachment of the graft to the root surface was mediated by a combination of epithelial downgrowth and connective tissue attachment. Minimal new bone and cementum formation was observed. The vascularization of the graft at 7 days originated from the periodontal plexus and the overlying flap. At 14 days, the graft was completely vascularized. At 28 and 60 days, normal vascularization was present. The vascularization of the connective tissue graft originates from the periodontal plexus, the supraperiosteal plexus, and the overlying flap. The attachment of the graft to the root surface appears to be mediated by a combination of epithelial downgrowth and connective tissue attachment. There is little potential for new cementum and new bone formation.
    Journal of Periodontology 05/2001; 72(4):470-8. · 2.40 Impact Factor
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    ABSTRACT: The aims of this study were to determine the accuracy of the computer assisted image analysis method and to evaluate its application for the assessment of periodontal wound healing in dogs. Histological material was analyzed with an optic microscope connected to a CCD color camera which transmitted the image to a frame grabber converting the light signals into pixels from which the measurements could be obtained. Twenty sections were read to assess the intra- and inter-examiner reproducibility for the parameters of area filled by new tissue, area of epithelium, area of bone and linear measurements of the cementum. The data were statistically analyzed using the t-test to test the hypothesis that there was no difference between and within examiners. No statistically significant differences were noted (with a confidence interval of 95%) for any parameter when intra-examiner reproducibility was assessed. Similar results were achieved for surface areas when the inter-examiner readings were computed. However, values of linear measurements for cementum showed statistically significant differences between recorders (p < 0.05). Results were consistently uniform and the method demonstrated high accuracy when intra-examiner readings were evaluated.
    Brazilian Dental Journal 01/2001; 12(3):167-72.
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    ABSTRACT: The aim of this study was to evaluate the effectiveness of a new bioresorbable barrier alone or in combination with BioOss for guided bone regeneration around dental implants with exposed implant threads. Five adult Macaca fascicularis monkeys were used in this investigation. After extraction of all premolars and first molars, two endosteal oral implants were installed in each quadrant and the bony defects were randomly treated with either: 1) placement of the new bioresorbable device alone (group 1); 2) placement of the new bioresorbable barrier in combination with BioOss (group 2); 3) placement of an ePTFE barrier in combination with BioOss (group 3); or (4) control (group 4). After a period of six months the animals were killed and the histological processing was performed. There was a significant difference in the amount of new bone regeneration around the implants between the four groups (i.e. groups 1, 2, 3 and 4) (P=0.0122). There was no difference, however, between group 2 and group 3. It can be concluded that the new bioresorbable barrier in combination with BioOss appears to obtain the same results in this type of bony defects as the grafting material in combination with an ePTFE barrier.
    International Journal of Oral and Maxillofacial Surgery 09/1998; 27(4):315-20. · 1.52 Impact Factor
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    ABSTRACT: This study focussed on the biologic success of 2 different procedures for root coverage. In the maxillary canines of 7 beagle dogs, buccal recessions were created and treated on one side with an ePTFE membrane (GTR-group) and on the contralateral side with a free connective tissue graft from the palate (CT-group). 2 areas served as negative controls. After 4 months of healing, histologic sections were processed and histologically analyzed. The evaluated parameters were coverage height, bone, cementum and connective tissue attachment regeneration, length of the epithelium, resorption, and ankylosis. Histologically, both GTR-group and CT-group produced more new bone, new cementum and new connective tissue attachment than the two control teeth. When histologically evaluated, the amount of new bone was more pronounced in the GTR-group than in the CT-group, however, no statistical differences in any of the evaluated parameters could be detected between the 2 procedures tested. Frequency and distribution of resorption and ankylosis were similar in the GTR-group and in the CT-group. Within the limits of this study, no differences in terms of the biologic rehabilitation between those recessions treated with ePTFE membranes and those treated with a free connective tissue graft could be found.
    Journal Of Clinical Periodontology 04/1998; 25(3):238-45. · 3.69 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the effectiveness of a new bioresorbable barrier alone or in combination with BioOss® for guided bone regeneration around dental implants with exposed implant threads. Five adult Macaca fascicularis monkeys were used in this investigation. After extraction of all premolars and first molars, two endosteal oral implants were installed in each quadrant and the bony defects were randomly treated with either: 1) placement of the new bioresorbable device alone (group 1); 2) placement of the new bioresorbable barrier in combination with BioOss® (group 2); 3) placement of an ePTFE barrier in combination with BioOss® (group 3); or (4) control (group 4). After a period of six months the animals were killed and the histological processing was performed. There was a significant difference in the amount of new bone regeneration around the implants between the four groups (i.e. groups 1, 2, 3 and 4) (P=0.0122). There was no difference, however, between group 2 and group 3. It can be concluded that the new bioresorbable barrier in combination with BioOss® appears to obtain the same results in this type of bony defects as the grafting material in combination with an ePTFE barrier.
    International Journal of Oral and Maxillofacial Surgery - INT J ORAL MAXILLOFAC SURG. 01/1998; 27(4):315-320.
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    ABSTRACT: The aim of this investigation was to evaluate clinically and histologically a new custom-made, root analogue titanium implant placed into extraction sockets in monkeys (Macaca fascicularis). Three adult monkeys were used in this investigation. After raising full thickness flaps on the buccal and lingual side, the upper central and lateral incisors were extracted. Each tooth root was machine copied to 1 titanium analogue using a new CAD/CAM-system. The implants were installed in the respective extraction sockets and the flaps sutured back. After 6 months of healing biopsies were taken and processed according to the cutting-grinding technique. The percentage of mineralized bone-to-implant contact was measured as a fraction of the rough implant surface using computer-assisted analysis. The main clinical problem that occurred during implant placement was the fracture of the buccal alveolar wall. The histometric evaluation showed a mean mineralized bone-to-implant contact of 41.2 +/- 20.6%. In this investigation it could be shown that implants fabricated by laser copying will osseointegrate. The presented data encourage the performance of clinical and experimental trials evaluating the new system utilizing improved second generation CAD/CAM equipment. Such studies are currently underway.
    Clinical Oral Implants Research 11/1997; 8(5):386-92. · 3.43 Impact Factor
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    ABSTRACT: The purpose of this study was to compare the clinical results of guided periodontal tissue regeneration (GPTR) using a resorbable barrier manufactured from a copolymer of polylactic and polyglycolic acids (Resolut Regenerative Material) with those of non-resorbable e-PTFE barrier (Gore-Tex Periodontal Material). 12 subjects participated, 6 with similarly paired class II furcations and 6 with 2 similar 2, 3-wall periodontal lesions. The resorbable and non-resorbable barriers were randomly assigned to 1 defect in each subject. Non-resorbable barriers were removed in six weeks. Plaque index (PlI), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and gingival recession (R) were recorded at baseline, (i.e., immediately prior to surgery) and at 12 months postsurgically. The clinical healing was similar and uneventful in both groups. Intrabony pockets depicted significant changes from baseline (p < 0.05) for probing depth reduction and gain in clinical attachment levels. No differences were found between treatments. Class II furcations showed significant improvements from baseline (p < or = 0.05) for probing depth reduction and clinical attachment gain. No differences were detected between treatments. It is concluded that the resorbable barrier tested is as effective as the nonresorbable e-PTFE barrier for the treatment of class II furcations and intrabony defects.
    Journal Of Clinical Periodontology 10/1997; 24(10):747-52. · 3.69 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract The purpose of this study was to compare the clinical results of guided periodontal tissue regeneration (GPTR) using a resorbable barrier manufactured from a copolymer of polylactic and polyglycolic acids (Resolut® Regenerative Material) with those of non-resorbable e-PTFE barrier (Gore-Tex® Periodontal Material). 12 subjects participated, 6 with similarly paired class II furcations and 6 with 2 similar 2,3-wall periodontal lesions. The resorbable and non-resorbable barriers were randomly assigned to 1 defect in each subject. Non-resorbable barriers were removed in six weeks. Plaque index (PII), gingival index (GI), probing depth (PD), clinical attachment level (CAL) and gingival recession (R) were recorded at baseline, (i.e., immediately prior to surgery) and at 12 months postsurgically. The clinical healing was similar and uneventful in both groups. Intrabony pockets depicted significant changes from baseline (p < 0.05) for probing depth reduction and gain in clinical attachment levels. No differences were found between treatments. Class II furcations showed significant improvements from baseline (p < 0.05) for probing depth reduction and clinical attachment gain. No differences were detected between treatments. It is concluded that the resorbable barrier tested is as effective as the nonresorbable e-PTFE barrier for the treatment of class II furcations and intrabony defects.
    Journal Of Clinical Periodontology 09/1997; 24(10):747 - 752. · 3.69 Impact Factor
  • Periodontology 2000 11/1995; 9:7-13. · 4.01 Impact Factor

Publication Stats

257 Citations
28.21 Total Impact Points

Institutions

  • 2002
    • Autonomous University of Nuevo León
      San Nicolás de los Garza, Nuevo León, Mexico
  • 1998–2002
    • University of Texas Health Science Center at Houston
      Houston, Texas, United States
    • University of Freiburg
      Freiburg, Baden-Württemberg, Germany
  • 2001
    • University of Texas at Tyler
      Tyler, Texas, United States