Lilian P L Lau

Publications (2)62.4 Total impact

• Source

  Available from: Marcelo F Gouveia Nogueira

  Article: The genome sequence of taurine cattle: a window to ruminant biology and evolution.

  Christine G Elsik, Ross L Tellam, Kim C Worley, Richard A Gibbs, Donna M Muzny, George M Weinstock, David L Adelson, Evan E Eichler, Laura Elnitski, Roderic Guigó, [......], Ashley J Waardenberg, Zhiquan Wang, Robert Ward, Rosemarie Weikard, Thomas H Welsh, Stephen N White, Laurens G Wilming, Kris R Wunderlich, Jianqi Yang, Feng-Qi Zhao
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  ABSTRACT: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
  Science 05/2009; 324(5926):522-8. · 31.20 Impact Factor
• Source

  Available from: Jeremy F Taylor

  Article: Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds.

  Richard A Gibbs, Jeremy F Taylor, Curtis P Van Tassell, William Barendse, Kellye A Eversole, Clare A Gill, Ronnie D Green, Debora L Hamernik, Steven M Kappes, Sigbjørn Lien, [......], Riccardo Negrini, Mike E Goddard, Ben J Hayes, Daniel G Bradley, Marcos Barbosa da Silva, Lilian P L Lau, George E Liu, David J Lynn, Francesca Panzitta, Ken G Dodds
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  ABSTRACT: The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.
  Science 05/2009; 324(5926):528-32. · 31.20 Impact Factor