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Publications (4)7.93 Total impact

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    ABSTRACT: To determine whether pulmonary vascular bed contributes to the development of in situ thrombosis and vascular remodelling in secondary pulmonary hypertension (SPH) via changes in its local secretory activities. Seventy-one patients with the diagnosis of secondary pulmonary hypertension (38 females, mean age 40.36+/-1.05 years) were included in the study. Selective right and left heart catheterization was performed to each patient for diagnostic purposes. Blood samples obtained from left ventricle (LV) and pulmonary artery (PA) of each patient were analyzed for levels of plasminogen activator inhibitor-1 (PAI-1), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), D-dimer, von Willebrand factor (vWF), protein-C, antithrombin-III, fibrinogen, and plasminogen. Results were compared between LV and PA. Correlation analysis between each parameter and mean pulmonary artery pressure (MPAP) was performed. Although mean level of VEGF in LV and PA were found to be in normal range, it was significantly higher in LV than in PA (p<0.001). Mean PDGF and D-dimer levels, which remained in normal range were also higher in LV (p<0.001 and p<0.001, respectively) than in PA;.vWF showed similar degree of elevation in both LV and PA. Only one parameter, PAI-1, was found to be significantly higher in PA than in LV (p=0.012). Antithrombin-III, protein C, plasminogen, and fibrinogen levels showed no significant differences between two chambers. They also remained in normal range, except for fibrinogen, which was slightly elevated in both LV and PA. Correlation analysis revealed strong positive correlation between D-dimer level in both LV and PA and MPAP (r=0.775, p<0.001 and r=0.649, p<0.001, respectively). In SPH, pulmonary vascular bed shows increased thrombotic, hypofibrinolytic, and proliferative activities, which are partially related to the severity of illness.
    Anadolu kardiyoloji dergisi: AKD = the Anatolian journal of cardiology 07/2005; 5(2):95-100. · 0.93 Impact Factor
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    ABSTRACT: Although patent ductus arteriosus (PDA) is the most common type of extracardiac shunt, aberrant PDA associated with other cardiac malformations as double brachiocephalic trunk and interrupted left subclavian artery is extremely rare. To the best of our knowledge, the literature contains no other report of a patient who has PDA originated from left subclavian artery associated with ventricular septal defect (VSD), double brachiocephalic trunk and interrupted left subclavian artery. &COPY; 2004 Elsevier Ireland Ltd. All rights reserved.
    International Journal of Cardiology 07/2005; 101(3):509-11. DOI:10.1016/j.ijcard.2004.03.038 · 4.04 Impact Factor
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    ABSTRACT: QT dispersion defined as interlead QT variability in a 12-lead electrocardiogram was proposed by Day and associates as a simple method to evaluate the repolarization heterogenicity of the ventricular myocardium. The frequency of onset of myocardial infarction and sudden death has been reported to have a circadian variation, with a peak incidence in the early morning hours. The authors investigated whether there is diurnal variation of QT interval and QT interval dispersion in healthy subjects and in patients with coronary artery disease. The study population consisted of two groups. Group I consisted of 62 subjects without coronary artery disease and group II consisted of 82 patients with coronary artery disease. Twelve-lead ECG was recorded for each patient in the morning (between 7 AM and 8 AM), afternoon (between 3 PM and 5 PM) and at night (between 11 PM and 1 AM), on the day after performance of coronary angiography. QTc dispersion was significantly higher in patients with coronary artery disease than in healthy subjects in the morning hours and afternoon (p<0.001). Although the differences were much prominent in group I than group II, both QTc dispersion of morning and afternoon were significantly greater than those at night. There were no statistically significant differences between group I and group II at nighttime with respect to maximum QTc, minimum QTc intervals, and QTc dispersion (p>0.05). In conclusion, QT dispersion shows diurnal variation with an increase in the morning hours in both patients with coronary artery disease and subjects without coronary artery disease. The mechanism of diurnal variation of QT dispersion in patients with coronary artery disease is quite different from that of healthy subjects.
    Angiology 05/2001; 52(5):311-6. DOI:10.1177/000331970105200503 · 2.97 Impact Factor
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    ABSTRACT: A Am ma aç ç:: Bu çal›flma, sekonder pulmoner hipertansiyonda (SPH) s›kl›kla izlenen in situ tromboz geliflimine ve vasküler yeniden biçimlenmeye pul- moner vasküler yata¤›n lokal katk›s›n› araflt›rmak için planlanm›flt›r. Y Yö ön nt te em mlle er r:: Kliniimizde kalp kateterizasyonu yap›lan 71 SPH hastas› (38 kad›n, 33 erkek; yafl ortalamas› 40.36± 1.05 y›l) çal›flmaya dahil edilmifl- tir. Her hastan›n pulmoner arter (PA) ve sol ventrikülünden (LV) al›nan kan örneklerinde plazminojen aktivator inhibitör-1 (PAI-1), trombosit kö- kenli büyüme faktörü (PDGF), damar endoteli büyüme faktörü (VEGF), D-Dimer, von-Willebrand faktörü (vWF), protein-C, antitrombin-III, fibrino- jen ve plazminojen düzeyleri bak›larak karfl›laflt›r›lm›flt›r. Ayr›ca her parametrenin ortalama PA bas›nc› (MPAP) ile korelasyonu araflt›r›lm›flt›r. B Bu ullg gu ulla ar r:: Ortalama VEGF düzeyi LV'de PA'e göre daha yüksektir (p