S Ishino

National Institute of Animal Health, Tsukuba, Ibaraki, Japan

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Publications (12)3.3 Total impact

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    ABSTRACT: A case of sex cord tumour with annular tubules was found in the right ovary of a 17-month-old Holstein cow. The tumour was characterized by tubules encircling hyaline bodies, which were composed of concentric lamellae of basal lamina. Several irregular tubular structures and a small component of granulosa cell differentiation were seen. Immunohistochemically, the neoplastic cells stained positively for oestradiol or testosterone.
    Journal of Comparative Pathology 06/1992; 106(4):423-7. DOI:10.1016/0021-9975(92)90026-Q · 1.10 Impact Factor
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    ABSTRACT: Pathological and immunohistochemical studies were performed on two cases of bovine follicular lymphoma with severe leukaemia and antibodies to bovine leukaemia virus. Histologically, numerous neoplastic follicular structures were observed in the lymph nodes and spleen of both cases and in the tonsils and Peyer's patches of one case. The neoplastic cells infiltrated diffusely into the liver, lungs and heart in both cases and into the tonsils, kidneys, abomasum and bone marrow in one case. Intracytoplasmic immunoglobulin was negative in the neoplastic cells. Follicular dendritic reticulum cells were decreased in number in the neoplastic follicles compared with those in normal lymphoid follicles. Follicular lymphoma is rare in cattle. Histological features of the present cases are distinguishable from the adult form of bovine lymphoma and the calf form of lymphoma.
    Journal of Comparative Pathology 11/1990; 103(3):265-75. DOI:10.1016/S0021-9975(08)80047-3 · 1.10 Impact Factor
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    ABSTRACT: Two cases of swine thymic lymphoma were investigated by electron microscopy and the immunoperoxidase method for terminal deoxynucleotidyl transferase (TdT), and furthermore sheep erythrocyte rosette assay was applied to one case. In case 1, immunoblastoid cells predominated and smaller cells were admixed with them. Many neoplastic cells were TdT-positive and formed rosettes with sheep erythrocytes at 4 degrees C, but about half of them formed rosettes at 37 degrees C. Ultrastructurally the neoplastic cells were characterized by highly irregular nuclei, poorly developed organelles and clustered dense bodies. The neoplasm in case 2 was composed of medium-sized to large cells and the latter predominated. A few of the neoplastic cells stained positively with anti-TdT serum. Ultrastructurally the neoplastic cells were characterized by nuclear convolution, narrow cytoplasmic bands and clustered dense bodies. The morphological features of thymic lymphomas were discussed in comparison with those of other swine lymphomas and lymphomas of other animals. Histological and immunological progression into T-immunoblastoid cells in case 1 was also discussed.
    Zentralblatt für Veterinärmedizin. Reihe A 10/1990; 37(8):592-600. DOI:10.1111/j.1439-0442.1990.tb00949.x
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    ABSTRACT: Malignant lymphomas of follicular centre cell (FCC) origin in 14 pigs are described. Seven cases were classified as abdominal type according to the distribution of the neoplastic lesions and the residual cases were of the general type. Most cases were composed of mixed populations of large and medium-sized neoplastic cells and the growing pattern varied from partially follicular to diffuse. The neoplastic cells often showed necrosis, to which macrophages reacted. A part of the neoplastic cells had cytoplasmic immunoglobulin M (CIgM) or cytoplasmic immunoglobulin G (CIgG). The histological features of swine FCC lymphomas are discussed.
    Zentralblatt für Veterinärmedizin. Reihe A 11/1989; 36(8):621-30. DOI:10.1111/j.1439-0442.1989.tb00773.x
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    ABSTRACT: Different types of lymphoid malignancy were observed in two sheep inoculated with BLV-containing materials. Sheep 1 showed severe leukemic change in the peripheral blood and splenomegaly but lymphosarcoma in the lymph nodes was absent. Sheep 2 had lymphosarcoma in the lymph nodes and various organs. Neoplastic cells had B-cell marker in both cases and a few neoplastic cells contained intracytoplasmic IgM in sheep 2. It was presumed that B-cells might be transformed into neoplastic cells on the way of their differentiation. Some of neoplastic cells might have ability of immunoglobulin-production in sheep 2.
    Nippon juigaku zasshi. The Japanese journal of veterinary science 09/1989; 51(4):749-56. DOI:10.1292/jvms1939.51.749
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    ABSTRACT: Two calves each were inoculated with 1.5 x 10(8) or 5 x 10(9) lymphocytes collected from each one cow which had persistent lymphocytosis (PL) and antibodies to bovine leukemia virus (BLV). A sudden increase in the number of peripheral blood lymphocytes (PBL) was observed 14 and 23 days, respectively, after inoculation and the maximum number reached 29,000 and 52,000/microliters 72 and 57 days after inoculation. Although the degree of PL decreased gradually in these cattle, it continued until 14 and 44 months after inoculation when one animal was sacrificed and the other died of lymphosarcoma. The PL was passaged in cattle by inoculation of a large number of PBL obtained from cattle at the stage of PL (PLL). The degree of PL was severer in cattle inoculated with a larger number of PLL. PL was not caused by inoculation of PBL obtained from either BLV-infected non-PL cattle or cattle free of BLV. The PL was also caused by inoculation of PLL into BLV-infected non-PL cattle. On the other hand, it was not observed after inoculation of a large amount of cell-free virus obtained from short-term cultures of PLL. Antibodies to BLV developed earlier and to higher levels in cattle inoculated with PLL than in those inoculated with cell-free virus. These facts show that infection with BLV was established more effectively by PLL than by cell-free virus, the infection may occur by lymphocyte to lymphocyte interaction and the actual number of infected BLV may have an important role in development of PL.
    Nippon juigaku zasshi. The Japanese journal of veterinary science 03/1989; 51(1):60-9. DOI:10.1292/jvms1939.51.60
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    ABSTRACT: Properties of peripheral blood lymphocytes (PBL) appearing during persistent lymphocytosis (PL) of cattle that was induced by inoculation of a large number of bovine leukemia virus (BLV)-infected lymphocytes were studied. The PBL possessed surface immunoglobulin at a high ratio and had high syncytium-forming activity. The PBL could not be distinguished from normal PBL cytogenetically. These PBL were shown to be polyclonal cells integrating BLV-proviral DNA randomly into their cellular DNA. These properties were similar to those of PBL appearing at the stage of PL of cattle naturally infected with BLV. The BLV-proviral DNA content of PBL and transcription of viral genes increased in parallel with development of PL and decreased along with a decline of PL indicating the possibility that gene expression and activation of BLV play an important role in induction and maintenance of PL.
    Nippon juigaku zasshi. The Japanese journal of veterinary science 03/1989; 51(1):70-8. DOI:10.1292/jvms1939.51.70
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    H Sentsui, Y Kono, S Itohara, S Ishino
    Nippon juigaku zasshi. The Japanese journal of veterinary science 01/1989; 50(6):1245-51. DOI:10.1292/jvms1939.50.1245
  • Zentralblatt für Veterinärmedizin. Reihe A 10/1988; 35(8):578-85.
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    S Ishino, M Nakazawa, I Matsuda
    Nippon juigaku zasshi. The Japanese journal of veterinary science 07/1987; 49(3):395-402. DOI:10.1292/jvms1939.49.395
  • K Kadota, S Ishino, H Nakajima
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    ABSTRACT: A case of swine thymic lymphoma is described. A young pig had a mediastinal mass and bone marrow involvement and the microscopic findings showed peripheral blood involvement. The tumour was composed of small to medium sized lymphoid cells which formed rosettes with sheep erythrocytes and were characterized by narrow cytoplasmic bands, nuclear convolution and clustered dense bodies. Such structural and immunological features resembled those of human thymic lymphomas derived from thymic T-cells.
    Journal of Comparative Pathology 08/1986; 96(4):371-8. DOI:10.1016/0021-9975(86)90032-0 · 1.10 Impact Factor
  • Nippon juigaku zasshi. The Japanese journal of veterinary science 01/1986; 47(6):1007-10. DOI:10.1292/jvms1939.47.1007