K V Pakhomenko

Publications (3)0 Total impact

• Article: [Long-term results of pre- and intraoperative radiotherapy in the combined treatment for stomach cancer].

  B A Berdov, Iu S Mardynskiĭ, V Iu Skoronad, L N Titova, K V Pakhomenko
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  ABSTRACT: The paper discusses the end results of combined treatment of stomach cancer (radical surgery plus pre- and intraoperative radiotherapy). A randomized evaluation showed that it might be used for loco-regional monitoring. Five-year rates and median of survival rose significantly, as compared with surgery alone, in tumor extension through the stomach wall (T3-4), metastatic dissemination to lymph nodes (N1-2), combinations of such pathologies as well as in cases of low-differentiated, undifferentiated and signet- cell cancer.
  Voprosy onkologii 02/2006; 52(5):515-20.
• Article: [Pre- and intraoperative radiotherapy for locally advanced gastric cancer in conjunction with extended lymph node dissection: results of phase II clinical study].

  V Iu Skoronad, B A Berdov, Iu S Mardynskiĭ, L N Titova, K V Pakhomenko
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  ABSTRACT: The paper discusses our findings on a phase II clinical study of an original procedure for therapy of locally advanced gastric cancer including pre- and intraoperative radiotherapy (IORT) and extended lymph node dissection. Out of 24 patients, none had intraoperative complications while postoperative ones developed in 16%; lethality rate was 4%. As far as immediate results are concerned, intensive pre- and intraoperative radiotherapy proved fully compatible with any surgical procedure including extended and extended-combined ones. Survival rates (Kaplan-Meier) were: 1 yr--90 +/- 6%; 2-, 3-year--74 +/- 9%. Indications of adjuvant radiotherapy and approaches to its effective use are discussed.
  Voprosy onkologii 02/2004; 50(5):585-9.
• Article: [Results of clinical studies of the efficacy of intraoperative radiotherapy in combined treatment of stomach cancer].

  V Iu Skoropad, B A Berdov, Iu S Mardynskiĭ, L N Titova, K V Pakhomenko
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  ABSTRACT: The results of clinical application of an original method of operable gastric cancer treatment including pre- and intraoperative irradiation (IORT) and radical intervention are presented. According to a randomized study, combination treatment did not involve intra- and postoperative complication rates higher than those of surgery alone. Moreover, a significant decrease in postoperative pancreatitis was registered. IORT is a highly effective method of adjuvant treatment of operable gastric cancer. Due to its application in conjunction with preoperative irradiation and radical surgery, the end results of locally-advanced gastric cancer improved.
  Voprosy onkologii 02/2001; 47(5):636-9.