Publications (4)13.21 Total impact
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Article: Long-term survival of arteriovenous fistulas in home hemodialysis patients.
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ABSTRACT: We report the outcome of arteriovenous (AV) fistulas created and managed by a multidisciplinary team in patients on hemodialysis (HD) over 20 years. We analyzed 432 AV fistulas in 301 home HD patients (12% diabetic; median age 47 years) followed for up to 161 months. Observed end points were spontaneous or surgical AV fistula closure, or construction of a new vascular anastomosis. Survival was analyzed for first and second AV fistulas and predictors of outcome for first AV fistulas. One vascular surgeon constructed 58% of AV fistulas. Three hundred sixty-seven AV fistulas were in the forearm, 64 at or above the elbow, and 1 in the thigh. Four hundred fourteen AV fistulas used in situ vessels, and 18 were autografts. Two hundred thirty-one anastomoses were side-to-side. Only five grafts were placed during this time. There were 131 second and subsequent AV fistulas in 76 patients, 79 (60%) of which required primary construction, and 52 used arterialized vessels from a previous AV fistula. The median time from formation to use for first and second AV fistula, respectively, was 2.39 (SE 0.35) and 3.2 (SE 1.9) months. Assisted survival from first use for first AV fistula was 90% at 1 year, 66% at 5 years, 84% at 1 year, and 72% at 2 years for second AV fistula. AV fistula survival from creation was superior for side-to-side anastomoses (P < 0.0001) and in men (P= 0.05). A multidisciplinary approach has been successful in providing durable AV fistulas for home HD for >95% of consecutive patients entering our program.Kidney International 06/2004; 65(5):1890-6. · 6.61 Impact Factor -
Article: Hypertension as a determinant of survival for patients treated with home dialysis.
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ABSTRACT: Previous studies of the risks of hypertension for dialysis patients have yielded conflicting results. The aim of this study was to investigate, in a home dialysis population with low rates of diabetes and antihypertensive drug use, whether blood pressure (BP) was an independent risk factor for survival. The outcome of 168 consecutive patients (94 male, 88% Caucasian), aged 48 years (SD 16), who began home hemodialysis (HD; N = 124) or home continuous ambulatory peritoneal dialysis (CAPD; N = 44) between January 1, 1985 and December 31, 1994 were analyzed retrospectively. Only 4.7% of patients took antihypertensive drugs while on dialysis. The patients were followed to December 31, 1998 with the primary outcome being all-cause mortality. Censoring events were transplantation, transfer to another center and treatment modality change. The Cox proportional hazard model was used with baseline predictors. Seventy-one patients died and the median overall survival was 4.2 years (5.6 on HD, 2.2 on CAPD, P < 0.0001). Mean BP at start of dialysis predicted survival on its own (P = 0.0009) and in the joint Cox model (P = 0.047). Other significant predictors in the joint model were age [10 year increase, relative hazard (RH) = 1.55, P = 0.0008], albumin (10 g/L decrease, RH = 2.05, P = 0.007), diabetes (RH = 3.42, P = 0.015) and peripheral vascular disease (RH = 2.19, P = 0.02) but not dialysis modality (RH = 1.63, P = 0.13). High and low mean blood pressure (BP) values at the start of dialysis were associated with the highest mortality. Among the home dialysis patients, most of whom did not require antihypertensive drugs, hypertension was a risk factor for survival and patients with mid-range BP values survived the longest.Kidney International 01/2003; 62(6):2281-7. · 6.61 Impact Factor -
Article: Computer-Aided Education to Aid Informed Decision Making Regarding Dialysis Treatment Options
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Article: Use of Computerised Clinical Database for Support of a Home Dialysis Programme
