Publications (2)1.17 Total impact
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Article: [Comparative study of the healing process of gastrographies with and without the use of Jatropha gossypiifolia L. (bellyache bush) extract in rats].
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ABSTRACT: The healing process of the gastrointestinal tract is of huge importance in the surgical field history, as well as the search for appropriate types of threads and suture techniques and the many factors that influence it. The use of phytotherapic drugs as accelerators of the healing process has been done for many years and is one of the current objectives of scientific researches trying to prove its therapeutic properties. To evaluate the use of Jatropha gossypiifolia L. extract on the healing process of gastrographies in rats. Forty wistar male rats were divided in 2 groups of 20 rats, named control and Jatropha groups. Ten animals of each group were killed in the third day post-surgery and were named control and Jatropha groups of the 3rd day. The remaining 10 animals of each group were killed in the seventh day and were named accordingly for the 7th day. In each animal, gastrostomy and gastrography were performed in a single plane using polypropylene thread 6-0 (Prolene). The animals from the Jatropha group were given a single dose of 200 mg/kg of the Jatropha gossypiifolia L. extract intraperitoneally on the same day of the procedure and the ones from the control group were given the same quantity in milliliters (ml), but of saline solution (sodium chloride 0.9%). The following parameters were evaluated: 1) macroscopic alterations; 2) the suture's resistance to atmospheric air insufflation (pressure of rupture); 3) histologic characteristics. No animal died during the clinical follow-up and optimal healing of the abdominal wall was seen without any signs of infection, dehiscence, abscesses or peritonitis. Healing of the serous surface was considered good in all animals, without occurrence of fistulas; however, intraperitoneal adhesions occurred in 7 rats of the sub-group control and 9 of the sub-group Jatropha on the 3rd day post-operative and in 9 of the sub-group control and 8 of the sub-group Jatropha on the 7th day, but the differences were not statistically significant between the groups. Healing of the mucous surface was classified as good in all the animals. The resistance of the gastrographies to the atmospheric air insufflation showed statistically significant increase of the rupture pressure in the Jatropha group during the 3rd day of observation. Histologic evaluation showed differences that were statistically significant, considered the criteria, as well as reduced acute inflammatory reaction and better coaptation of the edges in the sub-group Jatropha of 7th post-surgery, when compared to the sub-group control of the same period. The raw extract of Jatropha gossypiifolia L. aids the healing on the 3rd day post-surgery, concerning the enhanced resistance of the gastrographies to pressure of rupture, and on the 7th day, presenting better coaptation of the edges and reducing acute inflammatory reaction by microscopic analyses.Acta Cirurgica Brasileira 02/2006; 21 Suppl 3:40-8. · 0.58 Impact Factor -
Article: [Healing process in bladder suture of rats with and without the administration of intraperitoneal Jatropha gossypiifolia L. gross extract].
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ABSTRACT: The suture of tissues and their healing process is one of the basic fundamentals of surgery, and the research on substances which could improve the process is an ongoing challenge. The use of plants has been tested but till nowadays without scientific demonstration. To compare the macroscopic and histological alterations done by the use of intraperitoneal Jatropha gossypiifolia L. gross extract, in the healing process of sutures performed on the bladder of rats. Forty adult, male, Wistar rats were distributed into two animal groups. One centimeter longitudinal incision on the bladder ventral wall, and single plane synthesis with separated polyglactine 910 5-0 (Ethicon) stitches was done in all the animals. In the control group an intraperitoneal cavity instillation of distilled water at a ratio of 1 ml/kg/weight, and a 1 ml/kg/weight of Jatropha gossypiifolia L. extract for the Jatropha group was done representing 200 mg of the substance. Each group was subdivided into two with 10 animals in each, being submitted to euthanasia on 3rd and 7th post-operative days. Comparative histological, macroscopic and statistical analysis were undertaken between the subgroups. Statistical significant difference was observed in the acute inflammation changes, vascular neoformation and bonding on day 3; the first one was greater in the control group, and the latter two greater in the Jatropha group; acute inflammation variables and fibroblastic proliferation presented to be more intense on day 7, with statistical significance favoring the control group. No favorable healing effect was observed with the administration of single intraperitoneal dose of Jatropha gossypiifolia L. gross extract on the sutures of bladder in rats.Acta Cirurgica Brasileira 02/2006; 21 Suppl 2:23-30. · 0.58 Impact Factor
