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ABSTRACT: Ultra high fields (UHF) permit unprecedented explorations of functional organizations and insight into basic neuronal processes. Increases in the signal and contrast to noise ratios have allowed increases in the spatial resolution of T(2)(⁎) weighted gradient echo (GE) echo planar imaging (EPI). Furthermore, while the use of T(2) weighted imaging methods at UHF (e.g. spin echo (SE) EPI, gradient and spin echo (GRASE) EPI) can also permit higher resolution images, they in addition allow for increased spatial specificity of functional responses, permitting the in-vivo study of functional organizations down to the columnar level of the cortex. The study of the visual cortex has, thus far, benefitted the most from higher resolution T(2) weighted studies as achieving the required transmit B(1) magnitude at 7T is more challenging in other brain regions, such as the auditory cortex. As such, auditory fMRI studies at UHF have been limited to T(2)* weighted GE sequences. Recent advances in multi-channel RF transmission (e.g. B(1) shimming) have enabled procedures to efficiently address deficiencies in transmit B(1) profiles. However, these techniques, shown to be advantageous in anatomical imaging at UHF, are not generally utilized to facilitate T(2) weighted fMRI studies. Here we investigate the feasibility of applying B(1) shimming to achieve efficient RF transmission in the human auditory cortex. We demonstrate that, with B(1) shimming, functional responses to simple tones and to complex sounds (i.e. voices, speech, animal cries, tools and nature) can be efficiently measured with T(2) weighted SE-EPI in the bilateral human auditory cortex at 7T without exceeding specific absorption rate (SAR) limits.
NeuroImage 08/2012; 63(3):1313-20. · 5.89 Impact Factor
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Jinfeng Tian
03/2011; , ISBN: 9780470034590
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ABSTRACT: Temperatures were measured in vivo in four pigs (mean animal weight = 110.75 kg and standard deviation = 6.13 kg) due to a continuous wave radiofrequency (RF) power irradiation with a 31.75 cm internal diameter and a 15.24 cm long, 7 T (296 MHz), eight channel, transverse electromagnetic head coil. The temperatures were measured in the subcutaneous layer of the scalp, 5, 10, 15, and 20 mm deep in the brain, and rectum using fluoroptic temperature probes. The RF power was delivered to the pig's head for ∼3 h (mean deposition time = 3.14 h and standard deviation = 0.06 h) at the whole head average specific absorption rate of ∼3 W kg(-1) (mean average specific absorption rate = 3.08 W kg(-1) and standard deviation = 0.09 W kg(-1)). Next, simple bioheat transfer models were used to simulate the RF power induced temperature changes. Results show that the RF power produced uniform temperature changes in the pigs' heads (mean temperature change = 1.68°C and standard deviation = 0.13°C) with no plateau achieved during the heating. No thermoregulatory alterations were detected due to the heating because the temperature responses of the pre-RF and post-RF epochs were not statistically significantly different. Simple, validated bioheat models may provide accurate temperature changes.
Magnetic Resonance in Medicine 02/2011; 66(1):255-63. · 2.96 Impact Factor
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ABSTRACT: To study the effect of the extracranial portion of a deep brain stimulation (DBS) lead on radiofrequency (RF) heating with a transmit and receive 9.4 Tesla head coil.
The RF heating was studied in four excised porcine heads (mean animal head weight = 5.46 +/- 0.14 kg) for each of the following two extracranial DBS lead orientations: one, parallel to the coil axial direction; two, perpendicular to the coil axial direction (i.e., azimuthal). Temperatures were measured using fluoroptic probes at four locations: one, scalp; two, near the second DBS lead electrode-brain contact; three, near the distal tip of the DBS lead; and four, air surrounding the head. A continuous wave RF power was delivered to each head for 15 min using the coil. Net, delivered RF power was measured at the coil (mean whole head average specific absorption rate = 2.94 +/- 0.08 W/kg).
RF heating was significantly reduced when the extracranial DBS lead was placed in the axial direction (temperature change = 0-5 degrees C) compared with the azimuthal direction (temperature change = 1-27 degrees C).
Development of protocols seems feasible to keep RF heating near DBS electrodes clinically safe during ultra-high field head imaging.
Journal of Magnetic Resonance Imaging 09/2010; 32(3):600-7. · 2.70 Impact Factor
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ABSTRACT: The objective of this study was to investigate the feasibility of whole-body imaging at 7T. To achieve this objective, new technology and methods were developed. Radio frequency (RF) field distribution and specific absorption rate (SAR) were first explored through numerical modeling. A body coil was then designed and built. Multichannel transmit and receive coils were also developed and implemented. With this new technology in hand, an imaging survey of the "landscape" of the human body at 7T was conducted. Cardiac imaging at 7T appeared to be possible. The potential for breast imaging and spectroscopy was demonstrated. Preliminary results of the first human body imaging at 7T suggest both promise and directions for further development.
Magnetic Resonance in Medicine 01/2009; 61(1):244-8. · 2.96 Impact Factor
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Thomas Vaughan,
Lance DelaBarre,
Carl Snyder, Jinfeng Tian,
Can Akgun,
Devashish Shrivastava,
Wanzahn Liu,
Chris Olson,
Gregor Adriany,
John Strupp,
Peter Andersen,
Anand Gopinath,
Pierre-Francois van de Moortele,
Michael Garwood,
Kamil Ugurbil
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ABSTRACT: This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T.
Magnetic Resonance in Medicine 01/2007; 56(6):1274-82. · 2.96 Impact Factor
