[show abstract][hide abstract] ABSTRACT: The frontal leaves of Tectona grandis (Verabinaceae) are widely used in the folklore for the treatment of various kinds of wounds, especially burn wound. The present study was carried out to evaluate the effect of hydrochloric extract of Tectona grandis on experimentally induced wounds in rats and compare the effects observed with a known wound healing agent, Aloe vera. The models selected were excision wound, incision wound, burn wound and dead space wound. A suitable gel formulation was selected for the application using cellophane membrane penetration. In the excision wound and burn wound models, animals treated with Tectona grandis leaf extract showed significant reduction in period of epithelisation and wound contraction 50%. In the incision wound model, a significant increase in the breaking strength was observed. Tectona grandis leaf extract treatment orally produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue in dead space wound. It was concluded that Tectona grandis leaf extract applied topically (5% and 10% gel formulation) or administered orally (250 mg and 500 mg/kg body weight) possesses wound healing activity.
[show abstract][hide abstract] ABSTRACT: The study was designed to evaluate the hepatoprotective activity of P. guajava in acute experimental liver injury induced by carbon tetrachloride, paracetamol or thioacetamide and chronic liver damage induced by carbon tetrachloride. The effects observed were compared with a known hepatoprotective agent, silymarin. In the acute liver damage induced by different hepatotoxins, P. guajava leaf extracts (250 and 500mg/kg, po) significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. The higher dose of the extract (500 mg/kg, po) prevented the increase in liver weight when compared to hepatoxin treated control, while the lower dose was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, the higher dose (500 mg/kg, po) of P. guajava leaf extract was found to be more effective than the lower dose (250 mg/kg, po). Histological examination of the liver tissues supported the hepatoprotection. It is concluded that the aqueous extract of leaves of guava plant possesses good hepatoprotective activity.
Indian journal of experimental biology 05/2006; 44(4):305-11. · 1.20 Impact Factor
[show abstract][hide abstract] ABSTRACT: The hexane extract of oleo-gum-resin of Boswellia serrata (BSHE) was evaluated for its effect on liver injury induced by carbon tetrachloride, paracetamol or thioacetamide. The BSHE was given in two different doses (87.5 mg/kg p.o. and 175 mg/kg p.o.). Silymarin, a known hepatoprotective agent was used as standard. The lower dose of BSHE (87.5 mg/kg p.o.) significantly reduced the elevated levels of serum marker enzymes and prevented the increase in liver weight in all three models of liver injury, while the higher dose showed mild hepatoprotective activity. The hepatoprotective effect of lower dose of BSHE was supported by changes in histopathology. It was concluded that hexane extract of oleo-gum-resin of Boswellia serrata plant in lower doses possess hepatoprotective activity.
[show abstract][hide abstract] ABSTRACT: Rheumatoid arthritis is a chronic multi-system disease of unknown cause. It affects the people in their prime of life, predominantly between the ages of 20-50 years with unpredictable course. Sudard is used in the ayurvedic system of medicine for the treatment of inflammation and pain associated with rheumatoid arthritis, osteo-arthritis, frozen shoulder, sciatica, ankylosing spondylitis and chronic backache. Our study was aimed to evaluate efficacy of sudard using different animal models such as formalin (2% v/v)-induced acute inflammation, carrageen (1% v/v)-induced polyarthritis, adjuvant-induced arthritis, effect on subacute inflammation by sponge implantation technique and analgesic activity by Eddy's hot plate method. The results indicate that the formulation sudard possesses good anti-inflammatory, anti-arthritic and analgesic activities in the experimental animal models. Rheumatoid arthritis is a chronic multi-system dis-ease of unknown cause affecting people predominantly between the ages of 20-50 years with unpredictable course. If left unchecked, it leads to the destruction of the tissues within joints and consequent physical dis-ability in the greater majority. Although there are drugs that have been shown to improve signs and symptoms, alter the natural history of the disease and improve quality of life, but there is still no cure. In addition, these available therapies are asso-ciated with potential risks of death or irreversible organ damage. The challenge for society is to balance these known potential risks of therapy with acknowledged benefits despite the fact that these drugs do not lead to a cure. Sudard is used in the ayurvedic system of medicine for the treatment of inflammation and pain associated with rheumatoid arthritis, osteo arthritis, frozen shoul-der, sciatica, ankylosing spondylitis and chronic back ache. The formulation was made and marketed by refer-ring ancient ayurvedic literature that mentions that mix-ture of these herbs is beneficial for treatment of pain and fever. No scientific study has been carried out so far. Hence, the present study was carried out to evaluate analgesic, anti-inflammatory and anti-arthritic activity of sudard using different animal models.